Drinking Blocks a Chemical That Promotes Attention

Summary: Study sheds light on the brain chemistry involved in attention loss when a person drinks alcohol.

Source: UT Health San Antonio

In a new paper, researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) report brain chemistry that may contribute to why drinkers have difficulty paying attention while under the influence.

The work is funded by generous support from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation and by grants from the National Institute on Alcohol Abuse and Alcoholism and the National Institute of Mental Health.

Findings were published Dec. 2 in Nature Communications.

“When we want to focus on something, or when we stand up from a chair and become active, a brain stem nucleus releases a chemical called norepinephrine. Acute exposure to alcohol inhibits this signal in the brain,” said senior author Martin Paukert, MD, assistant professor of cellular and integrative physiology at UT Health San Antonio.

When attention is needed for a task, norepinephrine is secreted by a brain structure called the locus coeruleus. Scientists previously did not understand well what happens next, but Dr. Paukert and the team showed that the norepinephrine attaches to receptors on cells called Bergmann glia. This leads to a calcium rise in these cells.

Bergmann glia are astrocytes (caretaker or supporting cells) in the cerebellum, a region near the brain stem. “To our knowledge, this paper is the first description that norepinephrine in mammals directly binds to receptors on the Bergmann glia and activates them through calcium elevation,” Dr. Paukert said.

The researchers focused on the Bergmann glia but also demonstrated that the same phenomenon occurs in cortical astrocytes. “Most likely vigilance-dependent astrocyte calcium activation is inhibited throughout the brain by acute alcohol intoxication,” Dr. Paukert said.

Persons under the influence are off-balance when they walk. The researchers expected to find that the inhibition of calcium rise in Bergmann glia would also explain this. It didn’t. “The calcium elevation in Bergmann glia is not critical for motor coordination, which is somewhat surprising because the cerebellum is classically known for its role in motor control,” Dr. Paukert said.

This shows a glass of beer and a man's thumb
The researchers focused on the Bergmann glia but also demonstrated that the same phenomenon occurs in cortical astrocytes. Image is in the public domain

“However, our findings are in line with current suggestions that the cerebellum also plays critical roles in non-motor functions, and that astrocytes are not only supporting basic brain maintenance, but they may actively participate in cognitive function.”

The coauthors included Manzoor Bhat, PhD, professor and chairman of cellular and integrative physiology at UT Health San Antonio. “The beauty of the studies reported by Paukert and coauthors is that they have been conducted in real time in living and breathing animals using state-of-the-art technologies,” Dr. Bhat said. “The findings will open up new avenues of defining the brain circuits that ultimately determine the state of alertness, and how chemicals that interfere with those circuits essentially dampen this inherent vigilance system of the brain.”

The team utilized a technique called two-photon imaging to study specialized mice obtained from collaborators at Johns Hopkins University and Heidelberg University.

About this neuroscience research news

Source: UT Health San Antonio
Contact: Will Sansom – UT Health San Antonio
Image: The image is in the public domain

Original Research: Open access.
Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release” by Liang Ye, Murat Orynbayev, Xiangyu Zhu, Eunice Y. Lim, Ram R. Dereddi, Amit Agarwal, Dwight E. Bergles, Manzoor A. Bhat and Martin Paukert. Nature Communications


Abstract

Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

Norepinephrine adjusts sensory processing in cortical networks and gates plasticity enabling adaptive behavior. The actions of norepinephrine are profoundly altered by recreational drugs like ethanol, but the consequences of these changes on distinct targets such as astrocytes, which exhibit norepinephrine-dependent Ca2+ elevations during vigilance, are not well understood. Using in vivo two-photon imaging, we show that locomotion-induced Ca2+elevations in mouse astroglia are profoundly inhibited by ethanol, an effect that can be reversed by enhancing norepinephrine release. Vigilance-dependent astroglial activation is abolished by deletion of α1A-adrenergic receptor from astroglia, indicating that norepinephrine acts directly on these ubiquitous glial cells. Ethanol reduces vigilance-dependent Ca2+transients in noradrenergic terminals, but has little effect on astroglial responsiveness to norepinephrine, suggesting that ethanol suppresses their activation by inhibiting norepinephrine release. Since abolition of astroglia Ca2+ activation does not affect motor coordination, global suppression of astroglial networks may contribute to the cognitive effects of alcohol intoxication.

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