Neurexin regulates the survival of cerebellar granule cells independently of synapses. The findings shed new light on the mechanisms behind neurodevelopmental disorders like schizophrenia and ASD.
Even mild COVID-19 infection can lead to cognitive alterations and brain shrinkage, researchers report. The findings could help explain the brain changes that contribute to long-COVID.
Researchers have identified a new target in the brain that underpins the freezing response associated with anxiety and fear. The findings could provide a new drug target for anxiety-related disorders.
Inadequate sleep can harm brain organization in early adolescence, researchers report. The disorganization can have an impact on cognitive processes, including attention, memory, emotional regulation, and controlling behaviors.
Constant hunger associated with Prader-Willi syndrome is, in part, the result of disordered signaling in the cerebellum, an area of the brain associated with motor control and learning.
Researchers have identified a new, rare neurodevelopmental disorder associated with a homozygous mutation in the PRDM13 gene. Features of the disorder included intellectual disabilities, ataxia with cerebellar hypoplasia, and delayed puberty with hypogonadotropic hypogonadism.
New collaborative studies shed light on the organization of cells in key areas of the mouse brain and the organization of transcriptome, epigenomic, and regulatory factors that provide the brain cells with purpose and function.
Almost half of the identified human accelerated regions of the genome appear to act as neurodevelopment enhancers, researchers say. The findings shed new light on the genetic basis of human evolution.
Axonal swelling in the Purkinje cells of mice had no detrimental impact on firing rate or the speed at which axons transmit signals. At peak firing rate, axons with swellings were less likely to fail than those without.
The cerebellum underwent evolutionary changes that may have contributed to the development of language, culture, and tool use in humans, a new study reveals.