Study reveals a novel mechanism in locus coeruleus neurons caused by the loss of the GPT2 mitochondrial enzyme that is implicated in the development and progression of neurodegenerative diseases.
During REM sleep, the locus coeruleus stops releasing noradrenaline. By blocking the cascade, the association between memory and emotional response is broken. This may not occur so frequently in restless sleepers, resulting in rumination and PTSD-like symptoms. For those who usually sleep well, embarrassing feelings experienced at night may be reduced by morning.
Surprising events trigger the release of noradrenaline in the brain, helping to focus attention and learn from the experience.
Neuron activity in the locus coeruleus spikes when a mother mouse touches her pup to retrieve it.
A new framework describes how the locus coeruleus regulates the brain's sensitivity to relevant information during situations that require attention.
A new study reveals the role the locus coeruleus plays in learning, behavior, and mental health.
Motor learning deficits associated with autism may be the result of reduced levels of noradrenaline release in the primary motor cortex.
Study sheds light on the brain chemistry involved in attention loss when a person drinks alcohol.
Stimulating noradrenergic neurons in the locus coeruleus that carry signals from the brain down the spinal dorsal horn activates astrocytes. The astrocyte activation results in hypersensitivity to pain.
Study identifies a key role locus coeruleus neurons play in attentional control.
Exercise increases levels of galanin in the brain stem, making mice more resilient to stress.
Those on the autism spectrum had atypically smaller pupil dilation compared to the control group during distracting conditions while taking a push-button test. The findings suggest those with ASD may have dysregulation in locus coeruleus activity. The dysregulation of the LC may explain the exaggerated responses to environmental stimuli and fixated behaviors many with ASD experience.
