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          locus coeruleus

          This shows a brain.
          FeaturedNeurosciencePsychology
          ·May 15, 2025·5 min read

          Brain’s Arousal Regulator Found

          A new study reveals that a small cluster of cells near the brain's "blue spot"—the locus coeruleus—helps regulate arousal, attention, and stress responses. These peri-LC neurons modulate the locus coeruleus by releasing GABA, which reduces its activity and dampens the release of norepinephrine.
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          This shows a blue brain.
          Neuroscience
          ·April 25, 2025·5 min read

          Blue Brain Marker Peaks in Midlife, May Predict Cognitive Aging

          Researchers have mapped age-related changes in the brain’s locus coeruleus (LC), a region linked to cognition and Alzheimer’s risk, by tracking neuromelanin, a pigment that gives it its signature blue hue. In a diverse group of participants aged 19 to 86, they found an inverted U-shaped pattern: LC signal peaked in late middle age, then declined.
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          This shows a brain and a person sleeping.
          FeaturedNeuroscience
          ·November 25, 2024·6 min read

          Brain’s Locus Coeruleus Revealed as Key to Sleep Transitions

          A new study uncovers the role of the brain's locus coeruleus (LC) in regulating sleep cycles, managing transitions between NREM and REM sleep. This brainstem region alternates between activity peaks and troughs during sleep, acting like a clock to control sleep-state shifts.
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          This shows a brain.
          FeaturedNeuroscienceVisual Neuroscience
          ·May 2, 2024·6 min read

          Brainstem Plays Vital Role in Visual Attention

          Researchers highlights the locus coeruleus (LC), a small brainstem region, as critical in enhancing visual sensory processing through its production of norepinephrine. In the study scientists used optogenetics to activate these specific neurons in non-human primates, significantly improving their performance in a visual attention task.
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          This shows a woman sleeping.
          FeaturedNeuroscience
          ·September 22, 2023·4 min read

          Brain’s Blue Spot, Locus Coeruleus, Is A Key Player in Sleep Quality and Memory

          Researchers have shed light on the vital role of the locus coeruleus in regulating REM sleep and its effects on cognitive processes. Located deep in the brain, this nucleus manages noradrenaline, influencing memory, emotions, and sleep initiation.
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          This shows brain samples from the lc
          FeaturedNeurologyNeuroscience
          ·September 1, 2022·5 min read

          How a Brain Area Implicated in Alzheimer’s May Be Vulnerable to Degeneration

          Study reveals a novel mechanism in locus coeruleus neurons caused by the loss of the GPT2 mitochondrial enzyme that is implicated in the development and progression of neurodegenerative diseases.
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          This shows a woman sitting up in a dark room
          FeaturedNeurosciencePsychology
          ·July 14, 2022·3 min read

          Why Do Embarrassing Memories Seem to Surface at Night?

          During REM sleep, the locus coeruleus stops releasing noradrenaline. By blocking the cascade, the association between memory and emotional response is broken. This may not occur so frequently in restless sleepers, resulting in rumination and PTSD-like symptoms. For those who usually sleep well, embarrassing feelings experienced at night may be reduced by morning.
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          This shows neurons in the locus coeruleus
          FeaturedNeuroscience
          ·June 1, 2022·6 min read

          How the Brain Responds to Surprising Events

          Surprising events trigger the release of noradrenaline in the brain, helping to focus attention and learn from the experience.
          Read More
          This shows a mother mouse with her pups
          FeaturedNeuroscience
          ·March 24, 2022·3 min read

          Maternal Protective Behaviors Run Deep

          Neuron activity in the locus coeruleus spikes when a mother mouse touches her pup to retrieve it.
          Read More
          This shows a woman attempting to cross a road
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·January 7, 2022·5 min read

          How the Brain Helps Us Focus Our Attention

          A new framework describes how the locus coeruleus regulates the brain's sensitivity to relevant information during situations that require attention.
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          This shows the location of the LC in the brain
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·July 23, 2021·5 min read

          Neuroscientists Posit That Brain Region Is a Key Locus of Learning

          A new study reveals the role the locus coeruleus plays in learning, behavior, and mental health.
          Read More
          This shows a drawing of a mouse on a wheel and a print out of brain waves
          AutismFeaturedNeuroscience
          ·March 22, 2021·6 min read

          Researchers Close in on Root of Slow Motor Learning in Autism

          Motor learning deficits associated with autism may be the result of reduced levels of noradrenaline release in the primary motor cortex.
          Read More
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          This shows a brain model.

          3D-Printed Brain Model Mimics Neural Damage

          This shows a brain surrounded by stinky objects.

          How the Brain Decides a Smell Is Stinky

          This shows a brain.

          Low Sodium Linked to Anxiety Through Brain Chemistry Disruption

          This shows two cups of coffee.

          How You Take Your Coffee May Impact Your Risk of Early Death

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