Brain Connection Strength Varies With Fitness Levels in Older Adults

A new study shows that age-related differences in brain health – specifically the strength of connections between different regions of the brain – vary with fitness level in older adults. The findings suggest that greater cardiorespiratory fitness – a measure of aerobic endurance – relates to stronger brain connections and likely improves long-term brain function in aging populations.

The study results are reported in the journal NeuroImage.

Michelle Voss led the study while a postdoctoral researcher at the University of Illinois with Beckman Institute director Arthur Kramer and kinesiology and community health professor Edward McAuley. Voss now is an assistant professor at the University of Iowa.

“Our study provides the strongest evidence to date that fitness in an older adult population can have substantial benefits to brain health in terms of the functional connections of different regions of the brain,” Kramer said.

There are many ways to measure brain health across the lifespan. One popular technique measures the strength of connections between different parts of the brain while the person is completing a task or during wakeful rest. The latter is known as resting-state functional connectivity. Research has shown that some of these connections weaken with increasing age and indicate deteriorating brain health.

Using functional magnetic resonance imaging, Voss and colleagues measured the strength of these connections throughout the brain in younger and older adults at rest. As expected, the team confirmed that most connections were weaker for older adults when compared with younger adults.

Building on these findings, the researchers examined the role of cardiorespiratory fitness on resting-brain connectivity in older adults. Fitness is determined by how efficiently someone uses oxygen during physical activity such as running on a treadmill. Other factors aside from habitual physical activity may alter how fitness affects brain health. For example, a person’s genetic makeup can influence his or her fitness and general brain health.

The researchers found a relationship between fitness and the strength of the connections between certain brain regions in older adults at rest that was independent of their level of physical activity.

Drawing of a head with balls and lines circling the brain.
The researchers found a relationship between fitness and the strength of the connections between certain brain regions in older adults at rest that was independent of their level of physical activity. Image is for illustrative purposes only.

“An encouraging pattern in the data from our study and others is that the benefits of fitness seem to occur within the low-to-moderate range of endurance, suggesting that the benefits of fitness for the brain may not depend on being extremely fit,” Voss said.

The study concludes that there is a positive role of cardiorespiratory fitness, beyond habitual physical activity, on brain health as people age.

“The idea that fitness could be related to brain health regardless of one’s physical activity levels is intriguing because it suggests there could be clues in how the body adapts for some people more than others from regular activity. This will help our understanding of how fitness protects against age-related cognitive decline and dementia,” Voss said.

About this neuroscience and aging research

Funding: The study was funded by the NIH/National Institute on Aging, and Abbott Nutrition.

Source: Sarah Banducci – University of Illinois at Urbana-Champaign
Image Credit: The image is in the public domain
Original Research: Abstract for “Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging” by Michelle W. Voss, Timothy B. Weng, Agnieszka Z. Burzynska, Chelsea N. Wong, Gillian E. Cooke, Rachel Clark, Jason Fanning, Elizabeth Awick, Neha P. Gothe, Erin A. Olson, Edward McAuley, and Arthur F. Kramer in NeuroImage. Published online October 19 doi:10.1016/j.neuroimage.2015.10.044


Abstract

Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging

Greater physical activity and cardiorespiratory fitness are associated with reduced age-related cognitive decline and lower risk for dementia. However, significant gaps remain in the understanding of how physical activity and fitness protect the brain from adverse effects of brain aging. The primary goal of the current study was to empirically evaluate the independent relationships between physical activity and fitness with functional brain health among healthy older adults, as measured by the functional connectivity of cognitively and clinically relevant resting state networks. To build context for fitness and physical activity associations in older adults, we first demonstrate that young adults have greater within-network functional connectivity across a broad range of cortical association networks. Based on these results and previous research, we predicted that individual differences in fitness and physical activity would be most strongly associated with functional integrity of the networks most sensitive to aging. Consistent with this prediction, and extending on previous research, we showed that cardiorespiratory fitness has a positive relationship with functional connectivity of several cortical networks associated with age-related decline, and effects were strongest in the default mode network (DMN). Furthermore, our results suggest that the positive association of fitness with brain function can occur independent of habitual physical activity. Overall, our findings provide further support that cardiorespiratory fitness is an important factor in moderating the adverse effects of aging on cognitively and clinically relevant functional brain networks.

“Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging” by Michelle W. Voss, Timothy B. Weng, Agnieszka Z. Burzynska, Chelsea N. Wong, Gillian E. Cooke, Rachel Clark, Jason Fanning, Elizabeth Awick, Neha P. Gothe, Erin A. Olson, Edward McAuley, and Arthur F. Kramer in NeuroImage. Published online October 19 doi:10.1016/j.neuroimage.2015.10.044

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