Link Between ADHD and High Fluoride Levels in Pregnancy

Summary: Researchers report higher levels of urinary fluoride during pregnancy is associated with a higher risk of ADHD in school aged children. The study reports prenatal fluoride exposure is most strongly associated with inattentive behavior and cognitive problems in the children.

Source: University of Toronto.

Higher levels of urinary fluoride during pregnancy are associated with more ADHD-like symptoms in school-age children as reported by parents, according to a new study by researchers at the University of Toronto and other universities.

The findings, published today in Environment International, stem from the researchers’ analysis of data from 213 mother-child pairs in Mexico City that were part of the Early Life Exposures in Mexico to Environmental Toxicants project. The project recruited pregnant women from 1994 to 2005 and has continued to follow the women and their children ever since.

“Our findings are consistent with a growing body of evidence suggesting that the growing fetal nervous system may be negatively affected by higher levels of fluoride exposure,” said Morteza Bashash, the study’s lead author and a researcher at U of T’s Dalla Lana School of Public Health.

Tap water and dental products have been fluoridated in communities in Canada and the United States (as well as milk and table salt in some other countries) by varying amounts for more than 60 years to prevent cavities. In recent years, however, fierce debate over the safety of water fluoridation — particularly for children’s developing brains — has prompted researchers to explore the issue and provide evidence to inform national drinking water standards.

The study’s research team — including experts from the University of Toronto, York University, the National Institute of Public Health of Mexico, University of Michigan, Indiana University, the University of Washington and Harvard University — analyzed urine samples that had been obtained from mothers during pregnancy and from their children between six and 12 years of age to reconstruct personal measures of fluoride exposure for both mother and child.

The researchers then analyzed how levels of fluoride in urine related to the child’s performance on a variety of tests and questionnaires that measure inattention and hyperactivity, and provided overall scores related to ADHD, or Attention Deficit Hyperactivity Disorder. Analyses were adjusted for other factors known to impact neurodevelopment, such as gestational age at birth, birthweight, birth order, sex, maternal marital status, smoking history, age at delivery, education, socioeconomic status and lead exposure.

“Our findings show that children with elevated prenatal exposure to fluoride were more likely to show symptoms of ADHD as reported by parents,” said Bashash. “Prenatal fluoride exposure was more strongly associated with inattentive behaviours and cognitive problems, but not with hyperactivity,”

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The study analyzed data from 213 mother-child pairs in Mexico City image is adapted from the University of Toronto news release.

This work builds off of previous research the team published on this population demonstrating that higher levels of urine fluoride during pregnancy are associated with lower scores on tests of IQ and cognition in the school-age children.

ADHD is the most common psychiatric disorder diagnosed in childhood, affecting between five and nine per cent of all school-aged children.

“The symptoms of ADHD often persist into adulthood and can be impairing in daily life,” said Christine Till, an associate professor of psychology at York University and co-author on the study.

“If we can understand the reasons behind this association, we can then begin to develop preventive strategies to mitigate the risk,” said Till, who is also the principal investigator of another National Institutes of Health (NIH)-funded grant examining fluoride exposure in a large Canadian sample of pregnant women.

About this neuroscience research article

Funding: The study was funded by the National Institute of Environmental Health Sciences, part of the NIH.

Source: Nicole Bodnar – University of Toronto
Publisher: Organized by
Image Source: image is adapted from the University of Toronto news release.
Original Research: Abstract for “Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years of age in Mexico City” by Morteza Bashash, Maelle Marchand, Howard Hu, Christine Till, E. Angeles Martinez-Mier, Brisa N. Sanchez, Niladri Basu, Karen E. Peterson, Rivka Green, Lourdes Schnaas, Adriana Mercado-García, Mauricio Hernández-Avila, and Martha Marí Téllez-Rojoi in Environment International. Published October 10 2018.

Cite This Article

[cbtabs][cbtab title=”MLA”]University of Toronto”Link Between ADHD and High Fluoride Levels in Pregnancy.” NeuroscienceNews. NeuroscienceNews, 14 October 2018.
<>.[/cbtab][cbtab title=”APA”]University of Toronto(2018, October 14). Link Between ADHD and High Fluoride Levels in Pregnancy. NeuroscienceNews. Retrieved October 14, 2018 from[/cbtab][cbtab title=”Chicago”]University of Toronto”Link Between ADHD and High Fluoride Levels in Pregnancy.” (accessed October 14, 2018).[/cbtab][/cbtabs]


Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years of age in Mexico City

Epidemiologic and animal-based studies have raised concern over the potential impact of fluoride exposure on neurobehavioral development as manifested by lower IQ and deficits in attention. To date, no prospective epidemiologic studies have examined the effects of prenatal fluoride exposure on behavioral outcomes using fluoride biomarkers and sensitive measures of attention.

We aimed to examine the association between prenatal fluoride exposure and symptoms associated with attention-deficit/hyperactivity disorder (ADHD).

213 Mexican mother-children pairs of the Early Life Exposures to Environmental Toxicants (ELEMENT) birth cohort study had available maternal urinary samples during pregnancy and child assessments of ADHD-like behaviors at age 6–12. We measured urinary fluoride levels adjusted for creatinine (MUFcr) in spot urine samples collected during pregnancy. The Conners’ Rating Scales-Revised (CRS-R) was completed by mothers, and the Conners’ Continuous Performance Test (CPT-II) was administered to the children.

Mean MUFcr was 0.85 mg/L (SD = 0.33) and the Interquartile Range (IQR) was 0.46 mg/L. In multivariable adjusted models using gamma regression, a 0.5 mg/L higher MUFcr (approximately one IQR higher) corresponded with significantly higher scores on the CRS-R for DSM-IV Inattention (2.84 points, 95% CI: 0.84, 4.84) and DSM-IV ADHD Total Index (2.38 points, 95% CI: 0.42, 4.34), as well as the following symptom scales: Cognitive Problems and Inattention (2.54 points, 95% CI: 0.44, 4.63) and ADHD Index (2.47 points; 95% CI: 0.43, 4.50). The shape of the associations suggested a possible celling effect of the exposure. No significant associations were found with outcomes on the CPT-II or on symptom scales assessing hyperactivity.

Higher levels of fluoride exposure during pregnancy were associated with global measures of ADHD and more symptoms of inattention as measured by the CRS-R in the offspring.

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