Maltreatment Tied to Higher Inflammation in Girls

Summary: Girls who are abused in early life have higher levels of inflammation than boys who are maltreated and other children who did not experience abuse.

Source: University of Georgia

New research by a University of Georgia scientist reveals that girls who are maltreated show higher levels of inflammation at an early age than boys who are maltreated or children who have not experienced abuse. This finding may forecast chronic mental and physical health problems in midlife.

Led by psychologist Katherine Ehrlich, the study is the first to examine the link between abuse and low-grade inflammation during childhood.

Inflammation plays a role in many chronic diseases of aging–diabetes, cardiovascular disease, stroke, obesity–as well as mental health outcomes, and the findings suggest that maltreatment’s association with inflammation does not lie dormant before emerging in adulthood. Instead, the study shows that traumatic experiences have a much more immediate impact.

“We and others have speculated that there’s something about the immune system that’s getting calibrated, particularly during childhood, that might be setting people up on long-term trajectories toward accelerated health problems,” said Ehrlich, assistant professor in the Franklin College of Arts and Sciences.

“What I’m struck by is just how early in development we can see these effects. What our study highlights is that, even as early as childhood, we can see that a substantial portion of the children have levels of inflammation that the American Heart Association considers ‘moderate risk’ for heart disease. This is concerning from a public health perspective and suggests that these children may be at risk for significant health problems at an earlier age than their nonmaltreated peers.”

Participants in the study included 155 children aged 8-12 from low-income backgrounds who attended a weeklong day camp. The sample was racially diverse and included maltreated and nonmaltreated children.

Researchers captured detailed information on children’s exposure to abuse by utilizing Department of Human Services records about maltreatment experiences in families. The children-documented experiences included neglect (55%), emotional maltreatment (67%), physical abuse (35%) and sexual abuse (8%). Many children experienced more than one type of abuse, and 35% of children experienced abuse across multiple developmental periods.

The team measured five biomarkers of low-grade inflammation using non-fasting blood samples from the children.

Results revealed that childhood maltreatment–for girls–was associated with higher levels of low-grade inflammation in late childhood. Girls who had been abused over multiple periods or had multiple kinds of exposures had the highest levels of inflammation. Girls’ greatest risk for elevated inflammation emerged when they were abused early in life, before the age of 5.

For boys in the study, exposure to maltreatment was not reflected in higher levels of inflammation, but Ehrlich cautioned against drawing conclusions without additional research targeted to boys.

This shows a sad girl
This finding may forecast chronic mental and physical health problems in midlife. Image is in the public domain.

“One question is, are these variations due to developmental timing differences?” she said. “We know that girls mature faster than boys in terms of their biological and physical development. If we tested these same boys two years later, would we find the same patterns of inflammation that we found for the girls?”

Co-authors include Dante Cicchetti, University of Minnesota and University of Rochester; Gregory E. Miller, Northwestern University; and Fred A. Rogosch, University of Rochester.

Funding: This research was supported by MH083979 from the National Institute on Mental Health, DP2 MD013947 from the Common Fund, DA027827 from the National Institute on Drug Abuse and HL122328 from the National Heart, Lung, and Blood Institute. This work was also supported by a Jacobs Foundation Early Career Research Fellowship.

About this neurodevelopment research news

Source: University of Georgia
Contact: Katherine Ehrlich – University of Georgia
Image: The image is in the public domain

Original Research: Closed access.
Maltreatment exposure across childhood and low‐grade inflammation: Considerations of exposure type, timing, and sex differences” by Katherine Ehrlich et al. Developmental Psychobiology


Maltreatment exposure across childhood and low‐grade inflammation: Considerations of exposure type, timing, and sex differences

Links between child maltreatment and low‐grade inflammation in adulthood are well documented, but these studies often rely on adults to report retrospectively on experiences of childhood abuse. Furthermore, these findings raise questions about whether exposure to childhood maltreatment needs time to “incubate,” only giving rise to nonresolving inflammation in adulthood, or whether heightened inflammation may be observable in childhood, closer in time to the maltreatment exposure. The present study examined this question in a sample of 155 low‐income children (ages 8–12), half of whom had been exposed to maltreatment. Trained coders evaluated case reports to classify maltreatment based on timing and exposure type. Blood samples from children assessed C‐reactive protein and cytokines, which were used to form a composite of low‐grade inflammation. Analyses revealed a marginally significant Maltreatment Exposure × Sex interaction, which suggested that maltreatment exposure was associated with higher inflammation for girls but not boys. Additionally, analyses focused on the accumulation of maltreatment experiences (through multiple forms of maltreatment or across multiple time points) revealed that girls with greater diversity in their maltreatment experiences and those who experienced maltreatment at multiple time points were at greatest risk. Finally, examination of timing of first onset of maltreatment suggested that girls whose exposures occurred before the age of 5 had the highest low‐grade inflammation. These findings add new evidence linking maltreatment to inflammation in childhood, which could increase the risk for mental and physical health problems across the lifespan.

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