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Brain Tissue Structure Could Explain Link Between Memory and Fitness

Summary: Vicsoelasticity in the hippocampus is associated with better performance on both memory and fitness tests, a new study reports.

Source: University of Illinois.

Studies have suggested a link between fitness and memory, but researchers have struggled to find the mechanism that links them. A new study by University of Illinois researchers found that the key may lie in the microstructure of the hippocampus, a region in the middle of the brain involved in memory processes.

Aron Barbey, a professor of psychology, led a group of researchers at the Beckman Institute for Advanced Science and Technology at Illinois that used a specialized MRI technique to measure the structural integrity of the hippocampus in healthy young adults and correlated it with their performances on fitness and memory tests. They found that viscoelasticity, a measure of structural integrity in brain tissue, was correlated with fitness and memory performance – much more so than simply looking at the size of the hippocampus.

“Using a new tool to examine the integrity of the hippocampus in healthy young adults could tell us more about how this region functions and how to predict decline for early intervention,” Barbey said. “By the time we look at diseases states, it’s often too late.”

Prior research led by Illinois psychology professor Neal Cohen, who is also a co-author on the new paper, demonstrated that the hippocampus is critical for relational memory and that the integrity of this region predicts a host of neurodegenerative diseases. To date, much research on the hippocampus’ structure has focused on its size.

Studies in developing children and declining older adults have found strong correlations between hippocampal size and memory. However, size does not seem to matter as much in healthy young adults, said postdoctoral researcher Hillary Schwarb. The Illinois group looked instead at the microstructure of the tissue, using an emerging neuroimaging tool called magnetic resonance elastography. The method involves an MRI scan, but with a pillow under the subject’s head vibrating at a very low amplitude – as gentle as driving on the interstate, Schwarb said. The vibration is the key to measuring the structural integrity of the hippocampus.

“It’s a lot like sending ripples through a still pond – if there’s some large thing like a boulder under the surface, the ripples are going to displace around it,” Schwarb said. “We are sending waves through the brain and reconstructing the displacements into a map we can look at and measure.”

The study, published in the journal NeuroImage, found that those who performed better on the fitness test tended to also perform better on the memory task, confirming a correlation the group had noticed before. But by adding the information on the structure of the hippocampus, the researchers were able to find a possible pathway for the link. They found that the subjects with higher fitness levels also had more elastic tissue in the hippocampus. The tissue structure, in turn, was associated with memory.

Image shows brain scans.

Overview of hippocampal elastography procedure. Three-dimensional, full vector, complex displacement fields are captured with high spatial resolution (1.6 mm isotropic voxels) in the MRE acquisition for mechanical property estimation with nonlinear inversion (NLI). Hippocampal masks are generated and used to promote regional homogeneity during the estimation process through SPR, which reduces partial volume effects. NeuroscienceNews.com image is credited to Barbey et al./NeuroImage.

“We found that when the hippocampus is more elastic, memory is better. An elastic hippocampus is like a firm foam mattress pad that pops right back up after you get up,” said study co-author Curtis Johnson, a former graduate researcher at the Beckman Institute who is now a professor at the University of Delaware. “When the hippocampus is more viscous, memory is worse. A viscous hippocampus is like a memory-foam mattress that holds its shape even after you get up.”

The results suggest that the viscoelasticity of the hippocampus may be the mediating factor in the relationship between fitness and memory in healthy young adults.

“It also shows us that magnetic resonance elastography is a useful tool for understanding tissue microsctructure, and that microstructure is important to cognition,” Schwarb said. “This provides us a new level of analysis for studying the human brain.”

About this neuroscience research article

Funding: The Office of the Director of National Intelligence, Intelligence Advanced Research Projects Activity supported this work through grant number 2014-13121700004.

Source: Liz Ahlberg Touchstone – University of Illinois
Image Source: NeuroscienceNews.com image is credited to Barbey et al./NeuroImage.
Original Research: Full open access research for “Aerobic fitness, hippocampal viscoelasticity, and relational memory performanceā€¯ by Hillary Schwarb, Curtis L. Johnson, Ana M. Daugherty, Charles H. Hillman, Arthur F. Kramer, Neal J. Cohen, and Aron K. Barbey in NeuroImage. Published online March 30 2017 doi:10.1016/j.neuroimage.2017.03.061

Cite This NeuroscienceNews.com Article
University of Illinois “Brain Tissue Structure Could Explain Link Between Memory and Fitness.” NeuroscienceNews. NeuroscienceNews, 1 May 2017.
<http://neurosciencenews.com/memory-fitness-brain-structure-6451/>.
University of Illinois (2017, May 1). Brain Tissue Structure Could Explain Link Between Memory and Fitness. NeuroscienceNew. Retrieved May 1, 2017 from http://neurosciencenews.com/memory-fitness-brain-structure-6451/
University of Illinois “Brain Tissue Structure Could Explain Link Between Memory and Fitness.” http://neurosciencenews.com/memory-fitness-brain-structure-6451/ (accessed May 1, 2017).

Abstract

Aerobic fitness, hippocampal viscoelasticity, and relational memory performance

The positive relationship between hippocampal structure, aerobic fitness, and memory performance is often observed among children and older adults; but evidence of this relationship among young adults, for whom the hippocampus is neither developing nor atrophying, is less consistent. Studies have typically relied on hippocampal volumetry (a gross proxy of tissue composition) to assess individual differences in hippocampal structure. While volume is not specific to microstructural tissue characteristics, microstructural differences in hippocampal integrity may exist even among healthy young adults when volumetric differences are not diagnostic of tissue health or cognitive function. Magnetic resonance elastography (MRE) is an emerging noninvasive imaging technique for measuring viscoelastic tissue properties and provides quantitative measures of tissue integrity. We have previously demonstrated that individual differences in hippocampal viscoelasticity are related to performance on a relational memory task; however, little is known about health correlates to this novel measure. In the current study, we investigated the relationship between hippocampal viscoelasticity and cardiovascular health, and their mutual effect on relational memory in a group of healthy young adults (N=51). We replicated our previous finding that hippocampal viscoelasticity correlates with relational memory performance. We extend this work by demonstrating that better aerobic fitness, as measured by VO2max, was associated with hippocampal viscoelasticity that mediated the benefits of fitness on memory function. Hippocampal volume, however, did not account for individual differences in memory. Therefore, these data suggest that hippocampal viscoelasticity may provide a more sensitive measure to microstructural tissue organization and its consequences to cognition among healthy young adults.

“Aerobic fitness, hippocampal viscoelasticity, and relational memory performanceā€¯ by Hillary Schwarb, Curtis L. Johnson, Ana M. Daugherty, Charles H. Hillman, Arthur F. Kramer, Neal J. Cohen, and Aron K. Barbey in NeuroImage. Published online March 30 2017 doi:10.1016/j.neuroimage.2017.03.061

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