A password will be e-mailed to you.

3D Model of NFL Player’s Brain Reconstructs Moment of Impact

Summary: A new brain modelling study that looks at what happens to the brains of NFL players following a collision play, could shed light on the link between TBI and CTE, researchers say.

Source: Imperial College London.

Scientists have modelled what happens to the brain of an American footballer when he collides forcefully with another player.

The study, conducted by researchers at Imperial College London, was carried out to understand in more detail the link between traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE). The latter is a form of dementia and causes a long-term build-up of proteins called tau, associated with the degeneration of brain tissue and declining health.

TBI occurs when an external force impacts on the brain. People who have been involved in one-off TBI incidents such as motorcycle accidents, and sportspeople like footballers who have repetitive TBIs from collisions on the field, are both vulnerable to CTE. Scientists believe there is a link between the initial impact in a TBI and where tau deposits build up in the brain.

Now, Imperial researchers have modelled how brain tissue deforms during an impact between two American football players on the field. They have also modelled what happens to a person’s brain when they have a ground level fall and the initial impact to the brain in a motorcycle accident. They compared their 3D high-fidelity models to MRI data on a cohort of 97 patients with TBI, and studies on post-mortem data of the brains of footballers from America’s National Football Association (NFL) with CTE, previously donated to science institutes in America for analysis. They observed tau deposition in the brains, which was then diagnosed as CTE.

Dr Mazdak Ghajari, an engineer who co-led the study from the Dyson School of Design Engineering at Imperial College London, said: “In TBI, the force of the blow shakes the brain, which is similar in texture to jelly. This shaking process deforms the brain tissue and can cause ruptured blood vessels and damaged nerve cells, and more severe complications later on. We’ve been able to replicate those initial moments when the ‘jelly’ brain is first deformed on impact, by combining engineering principles and medical knowledge. This is providing us with new insights.”

The Imperial team showed in all their 3D models that the damage created from a TBI is greatest in the depths of the folds on the surface of the brain called sulci. Previous studies on CTE have shown that tau also accumulates in sulci. In addition, the team discovered that the location and severity of the blow to the head on impact can have a significant influence on the magnitude and pattern of the injury later on when CTE develops.

The researchers say further clarification of these links in future studies will be the key to analysing the long-term effects of head impacts. This could lead to new improvements in protective strategies, including new types of helmet designs.

Dr Ghajari added: “Current technologies for assessing helmet safety are pretty crude. Our work is still in the early stages, but we believe that it shows promise for more accurately modelling how the brain deforms in different types of impacts. Using this knowledge we could refine the design of particular areas of helmets so that they could withstand collisions associated with particular types of sports. We could also design headgear that is more able to shield motorcyclists, who are so vulnerable on the road. Ultimately, we think better protective wear may prevent long-term diseases such as CTE.”

Injury modelling

The team carried out their modelling by gathering data from real incidents. In the case of the American football players, the Imperial team used data that was originally collected by Biokinetics and Associates Ltd (Canada). The data was collected from NFL games that occurred from 1996 to 2001. A total of 182 collisions were recorded in the study. The Imperial team chose a collision that they thought was reconstructed well in the lab and input this data into their model.

The team reconstructed the second injury using medical records that detailed a patient’s fall to a marble floor, from ground level. They reconstructed the fall using a dummy and recorded the head accelerations during impact.

The accident involving a collision between a motorcyclist and a passenger car was reconstructed at the Transport Research Laboratory. Instruments were fitted inside a dummy head wearing a helmet, identical to the one worn in the accident, and the impacts were recorded. The location and velocity of the impact were adjusted to closely replicate the damage seen on the shell and lining of the helmet.

3D modelling technology

The information recorded from the sensors during each reconstruction was fed into a 3D model on a computer, created from MRI scans of a healthy 34-year-old male. The team’s software enabled them to pixelate the head into one million hexahedral elements and a quarter of a million quadrilateral elements, which represented 11 types of tissues including the scalp, skull, brain and anatomical features such as the sulci. This gave them the high fidelity capacity to focus in detail on parts most damaged from the initial impact of a TBI. They then compared their models with the MRI data and post-mortem studies of American footballers with CTE, which showed mechanical forces at the time of collision are concentrated in locations of tau deposition seen in the footballers’ brains with dementia.

The future

Professor David Sharp, co-author from the Department of Medicine at Imperial College London, said: “We are very excited by the ability to link the early and late effects of head injuries. A large challenge is identifying patients at risk of dementia after head injury and our study provides a way to connect the critical events in this process. We will be working to understand how the way the brain deforms leads to brain degeneration, as this will be key to protecting against dementia.”

The study was funded by Imperial College Research Fellowship Scheme, the National Institute of Health Resarch (NIHR) and the Medical Research Council, and has been published in the journal Brain. Future work will explore the implications of this study for helmet design.

The researchers plan to use the computer model to optimise the design of sporting headgears, with focus on two mainstream sports, American Football and Horse Riding.

The team will also be working with researchers from the Royal British Legion Centre for Blast Studies at Imperial, exploring the effects of blasts on brain tissue.

About this neuroscience research article

Source: Colin Smith – Imperial College London
Image Source: NeuroscienceNews.com images are credited to ICL.
Original Research: Full open access research for “Computational modelling of traumatic brain injury predicts the location of chronic traumatic encephalopathy pathology” by Mazdak Ghajari, Peter J. Hellyer, and David J. Sharp in Brain. Published online December 31 2016 doi:10.1093/brain/aww317

Cite This NeuroscienceNews.com Article
Imperial College London “3D Model of NFL Player’s Brain Reconstructs Moment of Impact.” NeuroscienceNews. NeuroscienceNews, 1 May 2017.
Imperial College London (2017, May 1). 3D Model of NFL Player’s Brain Reconstructs Moment of Impact. NeuroscienceNew. Retrieved May 1, 2017 from http://neurosciencenews.com/brain-impact-nfl-6547/
Imperial College London “3D Model of NFL Player’s Brain Reconstructs Moment of Impact.” http://neurosciencenews.com/brain-impact-nfl-6547/ (accessed May 1, 2017).


Computational modelling of traumatic brain injury predicts the location of chronic traumatic encephalopathy pathology

Traumatic brain injury can lead to the neurodegenerative disease chronic traumatic encephalopathy. This condition has a clear neuropathological definition but the relationship between the initial head impact and the pattern of progressive brain pathology is poorly understood. We test the hypothesis that mechanical strain and strain rate are greatest in sulci, where neuropathology is prominently seen in chronic traumatic encephalopathy, and whether human neuroimaging observations converge with computational predictions. Three distinct types of injury were simulated. Chronic traumatic encephalopathy can occur after sporting injuries, so we studied a helmet-to-helmet impact in an American football game. In addition, we investigated an occipital head impact due to a fall from ground level and a helmeted head impact in a road traffic accident involving a motorcycle and a car. A high fidelity 3D computational model of brain injury biomechanics was developed and the contours of strain and strain rate at the grey matter–white matter boundary were mapped. Diffusion tensor imaging abnormalities in a cohort of 97 traumatic brain injury patients were also mapped at the grey matter–white matter boundary. Fifty-one healthy subjects served as controls. The computational models predicted large strain most prominent at the depths of sulci. The volume fraction of sulcal regions exceeding brain injury thresholds were significantly larger than that of gyral regions. Strain and strain rates were highest for the road traffic accident and sporting injury. Strain was greater in the sulci for all injury types, but strain rate was greater only in the road traffic and sporting injuries. Diffusion tensor imaging showed converging imaging abnormalities within sulcal regions with a significant decrease in fractional anisotropy in the patient group compared to controls within the sulci. Our results show that brain tissue deformation induced by head impact loading is greatest in sulcal locations, where pathology in cases of chronic traumatic encephalopathy is observed. In addition, the nature of initial head loading can have a significant influence on the magnitude and pattern of injury. Clarifying this relationship is key to understanding the long-term effects of head impacts and improving protective strategies, such as helmet design.

“Computational modelling of traumatic brain injury predicts the location of chronic traumatic encephalopathy pathology” by Mazdak Ghajari, Peter J. Hellyer, and David J. Sharp in Brain. Published online December 31 2016 doi:10.1093/brain/aww317

Feel free to share this Neuroscience News.
No more articles