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CTE

Featured Neurology Neuroscience Open Neuroscience Articles

·April 20, 2022·7 min read

Study of Former Notre Dame Football Players Finds College Players More Likely to Have Brain Disorders

College football players are 5 times more likely to report cognitive impairment, 2.5 times more likely to experience recurrent headaches, and 65% more likely to have cardiovascular problems in their lifetime than their non-football playing peers. Additionally, mortality from brain and other nervous system cancers was 4 times higher in former college football players than the general population.

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Featured Genetics Neurology Neuroscience

·April 13, 2022·5 min read

Novel Root Cause of Tau-Induced Neurodegeneration Discovered

mRNA decay may facilitate tau-induced damage to the brain and associated apoptosis that contributes to a range of neurodegenerative disorders. Researchers found the mechanism can be altered pharmacologically, providing a new target for the development of therapeutics to prevent or slow the progression of some neurodegenerative disorders.

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Featured Genetics Neurology Neuroscience

·February 28, 2022·4 min read

A New Molecular Pathway Shared by Two Neurodegenerative Disorders Discovered

Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.

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Featured Neurology Neuroscience

·February 13, 2022·5 min read

The Risk of Concussion Lurks at the Super Bowl – And in All Other Sports

Researchers explore how changes in concussion research have impacted sports and player safety.

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Featured Neurology Neuroscience

·November 26, 2021·3 min read

Study Finds Brain Lesions on MRI Linked to Years of Playing Football

White matter hyperintensities were more common in athletes who played more contact sports or had more head injuries and concussions during their sporting careers.

Featured Neurology Neuroscience Open Neuroscience Articles

·June 7, 2021·2 min read

New Drug to Halt Dementia After Multiple Head Injuries

Blocking substance P following a head injury can prevent tau protein tangles from forming in the brain and lower the risk for CTE and other head injury associated dementias.

Featured Neurology Neuroscience

·April 7, 2021·4 min read

Memory and Executive Function Symptoms More Accurate for Predicting CTE Than Mood and Behavior

Cognitive symptoms such as problems with memory and executive function, but not mood or motor disorders, were associated with CTE pathology. The findings advance the ability to diagnose CTE in living people. Until now, post mortem analysis was the only reliable method to detect CTE.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·January 3, 2020·2 min read

Using gene therapy to treat CTE

A newly developed adeno-associated virus vector can deliver an anti-p Tau antibody directly to the hippocampus, significantly reducing pTau levels associated with CTE.

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Featured Neuroscience Psychology

·August 30, 2019·8 min read

Number of years in NFL plus certain positions portend greater risk for cognitive and mental health problems

Longer career length and playing specific positions put NFL players at greater risk of developing cognitive problems and mental health issues. Playing for 10 or more seasons increased the risks for depression, anxiety, and cognitive impairment twice as much than those who played for a single season. For every five seasons of play, the risks increase 20% for cognitive impairment. Those most at risk are running backs, linebackers and those who played special teams positions.

Featured Neurology Neuroscience Neuroscience Videos

·August 7, 2019·6 min read

Routine hits playing football cause damage to the brain

Sustained hits following one season of playing football are enough to cause structural alterations to the brain. When players sustain a concussion, structural brain integrity decreases, and levels of tau increase. Researchers say, while concussions are a prime concern for those who play football, sustained hits also pose a threat to neurological health.

Featured Neurology Neuroscience

·April 10, 2019·5 min read

Experimental PET scan detects abnormal tau protein in brains of living former NFL players

PET imaging of former NFL players who exhibited cognitive decline and psychiatric symptoms linked to CTE showed higher levels of tau in areas of the brain associated with the neurodegenerative disease.