Force, Not Frequency, Key to CTE Onset

Summary: Researchers redefined the leading factor contributing to chronic traumatic encephalopathy (CTE), a severe neurological disorder.

Traditionally, CTE was believed to stem from frequent head hits, regardless of concussions. However, this new study suggests the cumulative force of such impacts, not the sheer number, dictates the potential for later-life brain disease.

With the largest CTE study sample to date, this research revolutionizes our understanding of this condition linked to memory loss, impulsive behavior, depression, and suicidal thoughts.

Key Facts:

  1. The research studied 631 former football players, 71% of whom had some level of CTE. The worst cases were in players who had absorbed the greatest cumulative force of hits, not necessarily the most hits.
  2. The study utilized data from 34 published studies tracking impacts measured by sensors inside football helmets.
  3. The force of hits, termed “cumulative head impact index-g force” (CHII-G), was found to be a better predictor of CTE pathology and severity than the duration or number of hits.

Source: Boston University

For years, researchers studying chronic traumatic encephalopathy, or CTE, believed the primary cause of it was repetitive hits to the head, whether or not those hits caused concussions. They believed the more frequently that a person sustained head blows, the more likely they were to develop neurological and cognitive struggles later in life.

A new collaborative study conducted by researchers at Boston University, Mass General Brigham, and Harvard Medical School—using brains donated to BU’s UNITE Brain Bank and published this week in Nature Communications—adds a new wrinkle to the research around CTE.

The study found that the clearest predictor of what could cause a person to suffer brain disease later in life was the cumulative force of thousands of hits to the head, and not just the sheer volume of concussions suffered.

This shows two football players.
The worst forms of CTE showed up in players who had absorbed the greatest cumulative force of hits to the head, meaning they were hit often and hard. Credit: Neuroscience News

The study is the largest one to date, examining root causes of CTE, which is associated with everything from memory loss to impulsive behavior to suicidal thoughts and depression.

By using data from 34 published studies that tracked blows to the head measured by sensors inside of football helmets, the researchers were able to see how 631 former football players, whose brains were donated for research to BU, have been impacted.

The study found that 71 percent of the brains examined—451 of the 631—had some level of CTE, while 180 showed no sign of the disease.

The worst forms of CTE showed up in players who had absorbed the greatest cumulative force of hits to the head, meaning they were hit often and hard. (The individuals who absorb the hardest hits to the head are defensive backs, wide receivers, and running backs.)

To better understand the results of the study, and where CTE research goes next, The Brink posed some questions to Jesse Mez, senior author of the study. Mez is an associate professor of neurology at BU’s Chobanian & Avedisian School of Medicine, as well as the associate director of the BU Alzheimer’s Disease Research Center and codirector of clinical research at the BU CTE Center. 

The Brink: We have heard a lot about the impact of repetitive hits from football on the brain, starting at a young age. This latest research looks more closely at the force of those hits. Can you explain the findings in this latest work?

Mez: CTE is a neurodegenerative disease caused in part by exposure to repetitive head impacts, most commonly from contact sports.

Currently, CTE can only be definitively diagnosed postmortem, and most of the relationships we have observed with CTE have come from studies utilizing our UNITE Brain Bank, which includes over 1,300 brain donors with exposure to repetitive head impacts.

Previously, we have shown that there is a dose-response relationship between years of football play and risk for CTE. Our new study extends this finding by projecting football helmet sensor data obtained from living players onto our brain donors based on their duration, [and] level and position of play.

For each brain donor, we generated an estimated cumulative force (termed cumulative head impact index-g force, or CHII-G) of impacts experienced over the course of their football career.

We showed that the [estimated cumulative force] is a better predictor of CTE pathology and CTE severity than using years of play or cumulative hit count.

Can you explain how the force of the hits was measured, and is there anything you think can be done to reduce the force of these types of hits?

Across 34 different studies of football players who wore helmet sensors, we averaged the number of hits and force of those hits stratified by level and position of play over the course of a season.

We used this “positional exposure matrix” to derive the cumulative head impact for each donor. The CHII-G is a cumulative measure that accounts for both the number of hits and how hard those hits were over the course of a player’s career.

Anything that reduces the number of hits and force of the hits could be beneficial. This would include starting to play at an older age, playing fewer games, not hitting in practice, or reducing drills that encourage hard hitting.

Taken together, the volume of hits and the force of hits, where does this leave the research now on CTE? What’s next? Are you hopeful that leagues like the NFL are paying attention to the volume of research coming out and willing to consider changes to the sport?

I think that we’ve now demonstrated clearly that repetitive head impacts in football are a cause of CTE. Although similar relationships in other contact sports have not been studied in the way we have for football, there is growing evidence that similar relationships may exist.

Sports like ice hockey, boxing, MMA, rugby, and soccer need systematic investigations, as well. I’m hopeful that leagues and coaches take notice. For at least some of these sports, changes could substantially improve long-term neurodegenerative outcomes without dramatically changing the nature of the sport.

This research was supported by grant funding from the National Institutes of Health, the Department of Veterans Affairs, and the Department of Defense. 

About this CTE research news

Author: Katherine Gianni
Source: Boston University
Contact: Katherine Gianni – Boston University
Image: The image is credited to Neuroscience News

Original Research: Open access.
Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males” by Jesse Mez et al. Nature Communications


Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear.

We create a position exposure matrix (PEM), composed of American football helmet sensor data, summarized from literature review by player position and level of play. Using this PEM, we estimate measures of lifetime RHI exposure for a separate cohort of 631 football playing brain donors.

Separate models examine the relationship between CTE pathology and players’ concussion count, athletic positions, years of football, and PEM-derived measures, including estimated cumulative head impacts, linear accelerations, and rotational accelerations.

Only duration of play and PEM-derived measures are significantly associated with CTE pathology.

Models incorporating cumulative linear or rotational acceleration have better model fit and are better predictors of CTE pathology than duration of play or cumulative head impacts alone.

These findings implicate cumulative head impact intensity in CTE pathogenesis.

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