“Excitingly, our discovery provides a new template for how neuronal computations may be implemented in brain circuits.”
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Source: Donna Lu – University of Queensland Image Source: NeuroscienceNews.com image is in the public domain. Original Research: Full open access research for “Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells” by A. Brombas, S. Kalita-de Croft, E. J. Cooper-Williams & S. R. Williams in Nature Communications. Published online June 7 2017 doi:10.1038/ncomms15683
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[cbtabs][cbtab title=”MLA”]University of Queensland “Shedding Light on How Our Brain Processes Visual Cues.” NeuroscienceNews. NeuroscienceNews, 7 June 2017. <https://neurosciencenews.com/visual-cue-eye-processing-6856/>.[/cbtab][cbtab title=”APA”]University of Queensland (2017, June 7). Shedding Light on How Our Brain Processes Visual Cues. NeuroscienceNew. Retrieved June 7, 2017 from https://neurosciencenews.com/visual-cue-eye-processing-6856/[/cbtab][cbtab title=”Chicago”]University of Queensland “Shedding Light on How Our Brain Processes Visual Cues.” https://neurosciencenews.com/visual-cue-eye-processing-6856/ (accessed June 7, 2017).[/cbtab][/cbtabs]
The retina processes visual images to compute features such as the direction of image motion. Starburst amacrine cells (SACs), axonless feed-forward interneurons, are essential components of the retinal direction-selective circuitry. Recent work has highlighted that SAC-mediated dendro-dendritic inhibition controls the action potential output of direction-selective ganglion cells (DSGCs) by vetoing dendritic spike initiation. However, SACs co-release GABA and the excitatory neurotransmitter acetylcholine at dendritic sites. Here we use direct dendritic recordings to show that preferred direction light stimuli evoke SAC-mediated acetylcholine release, which powerfully controls the stimulus sensitivity, receptive field size and action potential output of ON-DSGCs by acting as an excitatory drive for the initiation of dendritic spikes. Consistent with this, paired recordings reveal that the activation of single ON-SACs drove dendritic spike generation, because of predominate cholinergic excitation received on the preferred side of ON-DSGCs. Thus, dendro-dendritic release of neurotransmitters from SACs bi-directionally gate dendritic spike initiation to control the directionally selective action potential output of retinal ganglion cells.
“Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells” by A. Brombas, S. Kalita-de Croft, E. J. Cooper-Williams & S. R. Williams in Nature Communications. Published online June 7 2017 doi:10.1038/ncomms15683