Neuroscience News logo for mobile.
  • Neuroscience News
  • Neuroscience
  • Disorders
  • Programs
  • Advertise
    • Newsletter Ads
  • Submit News
  • Subscribe
  • Register
  • Discussions
    • Discussion Groups
    • Neuroscience Forums
    • Activity
    • Members
Neuroscience News Logo
Neuroscience News Small Logo
  • Neuroscience
    Neuroscience

    Neuroscience research articles are provided.

    What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.

    This shows a sad woman

    Routine Depression Screening May Capture Underdiagnosed Patient Populations

    This shows projections from the eyes

    Touch and Sight Are Linked Before Birth

    This shows a model of a DNA strand

    Differences in Genetic Influences Among People All Along the Autism Spectrum

    • Open Access Neuroscience
    • Electrophysiology
    • Neuroscience Opinions
    • Neuroscience Videos
    • Sponsored Neuroscience News
  • Neurology
    Neurology

    – These articles focus mainly on neurology research.
    – What is neurology?
    – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them.
    – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.

    This shows a brain

    New Dementia Risk Genes Identified Through Novel Testing Approach

    This shows a brain

    How DDT Exposure Contributes to Alzheimer’s Disease Risk

    This shows a brain

    Reprogramming Human Skin Cells Into Aged Neurons to Study Neurodegenerative Disorders

    • Alzheimer’s Disease
    • Brain Research
    • Brain Cancer
    • Autism
    • Epilepsy
    • Traumatic Brain Injuries
    • Parkinson’s Disease
  • Psychology
    Psychology

    What is Psychology?
    Definition of Psychology: Psychology is the study of behavior in an individual, or group. Our psychology articles cover research in mental health, psychiatry, depression, psychology, schizophrenia, autism spectrum, happiness, stress and more.

    This shows a sad woman

    Routine Depression Screening May Capture Underdiagnosed Patient Populations

    This shows a woman drinking a hot drink with a friend

    Random Acts of Kindness Make a Bigger Splash Than Expected

    This shows a burger and fries

    ‘Cheat Meals’ Linked to Eating Disorders in Adolescents and Young Adults

    • Schizophrenia
    • Depression
    • Bipolar Disorder
    • Mental Health
  • AI
    AI
    This shows a woman's back

    AI Could Help Patients With Chronic Pain Avoid Opioids

    This shows a brain

    Researchers Create Most Realistic Computer Models of Brain Cells

    This shows cartoons of fabels like the hare and the turtle

    Machines Can Learn From Fables

    • Neural Networks
    • Deep Learning
    • Machine Learning
  • Robotics
    Robotics

    Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.

    This shows the robot doing different chores

    Robots Learn Household Tasks by Watching Humans

    This shows a robotic tabby cat

    Introducing a Protocol for Using Robotic Pets in Memory Care

    This shows a robotic arm in motion

    A Robot Learns to Imagine Itself

  • Genetics
    Genetics

    Genetics articles related to neuroscience research will be listed here.

    This shows a model of a DNA strand

    Differences in Genetic Influences Among People All Along the Autism Spectrum

    This shows a brain

    New Dementia Risk Genes Identified Through Novel Testing Approach

    This shows a range of spicy dishes and spices

    The Taste for Specialty Foods Is in Our Genes

  • Neurotech
    Neurotech

    Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.

    This shows a brain

    Researchers Create Most Realistic Computer Models of Brain Cells

    This shows the images created by ultasound

    Imaging the Brain With Ultrasound Waves

    This shows the robot doing different chores

    Robots Learn Household Tasks by Watching Humans

    • Brain Computer Interfaces
    • Neuroprosthetics
  • About
    • Neuroscience Newsletters
    • Privacy Policy
    • Contact Neuroscience News
    • Neuroscience News Sitemap
    • Log In
  • Trending
    NowWeekMonth
    This shows a cup of coffee

    Coffee and Cigarettes: Research Sheds New Light on Nicotine and Morning Brew

    This shows a bowl of spinach

    Consuming Green Vegetables and Certain Supplements Suppresses Inflammatory Bowel Disease

    This shows the outline of a head

    Misophonia Is More Than Just Hating the Sound of Chewing

    This shows the outline of a head

    A New Theory in Physics Claims to Solve the Mystery of Consciousness

    This shows a record on a record player

    Musical Tests Can Detect Mental Deterioration in Old Age

Reading
Protein That Increases Effectiveness of Vaccines Discovered
ShareTweet
Home
Featured

Protein That Increases Effectiveness of Vaccines Discovered

FeaturedNeurologyOpen Neuroscience Articles
·April 7, 2017

Summary: A new study identifies a protein that may help make vaccines more effective and provide protection from diseases such as cancer.

Source: Boston University Medical Center.

Researchers have discovered a protein they believe would help make vaccinations more effective and provide protection from other diseases such as cancer.

The findings, which appear online in Scientific Reports, allows for greater understanding of how vaccine enhancers work and can best be used.

Researchers from Boston University School of Medicine (BUSM) purified a protein found on the exterior of bacteria (neisseria meningidis) and used it as an accessary to provide a better vaccination response. Typically, vaccines can either increase the amount of antibody production or they can stimulate cells (called cytotoxic T cells) to directly kill the offending agent. In this case, the protein, called PorB, is unique in that it can do both.

“This study has wide implications as it could not only be used to help the body identify and fight off bacterial infections, but it could also potentially help the body use its own machinery to fight off other diseases like cancer, HIV, and influenza before they have a chance to establish within the body,” explained corresponding author Lee Wetzler, MD, professor of medicine and microbiology at BUSM.

Image shows a person receiving a vaccination.
The model that received the PorB had an increase in the response to the vaccine antigen, evidenced by an increased number of activated cells in the lymph nodes and a gain in the production of cytotoxic T cells, as compared to the vaccination with the antigen alone. NeuroscienceNews.com image is for illustrative purposes only.

In this study, the researchers used two experimental models. The first model was given a vaccination with antigen and mixed PorB, while the second model was given the antigen alone. The model that received the PorB had an increase in the response to the vaccine antigen, evidenced by an increased number of activated cells in the lymph nodes and a gain in the production of cytotoxic T cells, as compared to the vaccination with the antigen alone.

“Our study deepens the general understanding of how vaccine adjuvants modulate immune responses. The antigen formulation with PorB triggers a sequence of cellular events at the periphery and in lymphoid tissue that are critical for the establishment of protection to a broad array of infectious diseases, and maybe for other diseases like cancer,” added Wetzler, a physician in Boston Medical Center’s Department of Infectious Diseases.

About this neurology research article

Funding: Funding for this study was provided by a National Institutes of Health grant AI040944.

Source: Gina DiGravio – Boston University Medical Center
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Full open access research for “The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation” by Michael L. Reiser, Munir M. Mosaheb, Christina Lisk, Andrew Platt & Lee M. Wetzler in Scientific Reports. Published online April 7 2017 doi:10.1038/s41598-017-00555-4

See also
This shows a woman warming up for a run
FeaturedNeuroscience
·April 25, 2022·5 min read

Controlling Blood Sugar May Improve Response to Exercise Training

Cite This NeuroscienceNews.com Article

[cbtabs][cbtab title=”MLA”]Boston University Medical Center “Protein That Increases Effectiveness of Vaccines Discovered.” NeuroscienceNews. NeuroscienceNews, 7 April 2017.
<https://neurosciencenews.com/vaccine-protein-porb-6363/>.[/cbtab][cbtab title=”APA”]Boston University Medical Center (2017, April 7). Protein That Increases Effectiveness of Vaccines Discovered. NeuroscienceNew. Retrieved April 7, 2017 from https://neurosciencenews.com/vaccine-protein-porb-6363/[/cbtab][cbtab title=”Chicago”]Boston University Medical Center “Protein That Increases Effectiveness of Vaccines Discovered.” https://neurosciencenews.com/vaccine-protein-porb-6363/ (accessed April 7, 2017).[/cbtab][/cbtabs]


Abstract

The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation

TOLL-like receptor (TLR) ligands activate both innate and adaptive immune cells, while modulating the cellular immune response. The outer membrane protein (OMP) from Neisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an adjuvant. Here, we demonstrate that PorB increases the level of OVA in the endo-/lysosomal cellular compartment of BMDCs, increases antigen presenting cell (APC) trafficking to draining lymph nodes, and enhances antigen cross-presentation. PorB is capable of mounting an antigen specific T cell response by efficiently stimulating antigen cross-presentation in vivo and in vitro assessed by BMDC OT-I cocultivation assays. The enhanced antigen cross-presentation and the increased APC recruitment to secondary lymphoid tissues expand the scope of known adjuvant effects of PorB on the immune system. Our findings lead to a better understanding of how TLR-ligand based adjuvants can alter and modulate immune responses.

“The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation” by Michael L. Reiser, Munir M. Mosaheb, Christina Lisk, Andrew Platt & Lee M. Wetzler in Scientific Reports. Published online April 7 2017 doi:10.1038/s41598-017-00555-4

Feel free to share this Neuroscience News.
Join our Newsletter
I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )
Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free.
We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.
Tags
Boston University Medical CenterCancercytotoxic T cellsGeneticsHealthlymph nodesneisseria meningidisNeuroscienceOpen Accessopen scienceOVAPorBTLRTOLL-like receptorvaccinesvirology
ShareTweetShareShareSubmitEmail
Neuroscience News
Neuroscience News posts science research news from labs, universities, hospitals and news departments around the world. Science articles can cover neuroscience, psychology, AI, robotics, neurology, brain cancer, mental health, machine learning, autism, Parkinson's, Alzheimer's, brain research, depression and other topics related to cognitive sciences.
Related
This shows a sad woman

Routine Depression Screening May Capture Underdiagnosed Patient Populations

This shows projections from the eyes

Touch and Sight Are Linked Before Birth

This shows a model of a DNA strand

Differences in Genetic Influences Among People All Along the Autism Spectrum

Neuroscience News Footer Logo
  • Facebook
  • Twitter
  • Instagram
  • Linkedin
  • Tumblr

Neuroscience News Sitemap
Neuroscience Graduate and Undergraduate Programs
Free Neuroscience MOOCs
Neuroscience Groups
About
Contact Us
Privacy Policy
Submit Neuroscience News
Subscribe for Emails

Coronavirus News
Neuroscience Research
Psychology News
Brain Cancer Research
Alzheimer’s Disease
Parkinson’s News
Autism / ASD News
Neurotechnology News
Artificial Intelligence News
Robotics News

Search Neuroscience News

Neuroscience News
  • Neuroscience
    • Open Access Neuroscience
    • Electrophysiology
    • Neuroscience Opinions
    • Neuroscience Videos
    • Sponsored Neuroscience News
  • Neurology
    • Alzheimer’s Disease
    • Brain Research
    • Brain Cancer
    • Autism
    • Epilepsy
    • Traumatic Brain Injuries
    • Parkinson’s Disease
  • Psychology
    • Schizophrenia
    • Depression
    • Bipolar Disorder
    • Mental Health
  • AI
    • Neural Networks
    • Deep Learning
    • Machine Learning
  • Robotics
  • Genetics
  • Neurotech
    • Brain Computer Interfaces
    • Neuroprosthetics
  • About
    • Neuroscience Newsletters
    • Privacy Policy
    • Contact Neuroscience News
    • Neuroscience News Sitemap
    • Log In
Neuroscience News Small Logo
  • Neuroscience
    • Open Access Neuroscience
    • Electrophysiology
    • Neuroscience Opinions
    • Neuroscience Videos
    • Sponsored Neuroscience News
  • Neurology
    • Alzheimer’s Disease
    • Brain Research
    • Brain Cancer
    • Autism
    • Epilepsy
    • Traumatic Brain Injuries
    • Parkinson’s Disease
  • Psychology
    • Schizophrenia
    • Depression
    • Bipolar Disorder
    • Mental Health
  • AI
    • Neural Networks
    • Deep Learning
    • Machine Learning
  • Robotics
  • Genetics
  • Neurotech
    • Brain Computer Interfaces
    • Neuroprosthetics
  • About
    • Neuroscience Newsletters
    • Privacy Policy
    • Contact Neuroscience News
    • Neuroscience News Sitemap
    • Log In
Neuroscience News LogoNeuroscience News
This shows a sad woman

Routine Depression Screening May Capture Underdiagnosed Patient Populations

This shows projections from the eyes

Touch and Sight Are Linked Before Birth

This shows a model of a DNA strand

Differences in Genetic Influences Among People All Along the Autism Spectrum

This shows a woman drinking a hot drink with a friend

Random Acts of Kindness Make a Bigger Splash Than Expected

Start typing to see results or hit ESC to close
Neuroscience neurobiology brain research Psychology Neurology
See all results

Lost your password?
Forgotten Password
Cancel