Understanding how tics are suppressed may help some at risk for tic disorders

Summary: Almost 20% of children develop facial or vocal tics by the time they are elementary school age. For many children, knowing others are watching them helps to reduce tic behaviors. A history of anxiety disorder has been associated with tics in young children. Understanding more about tic behaviors in children may help to develop new strategies to help those with Tourette suppress tics.

Source: WUSTL

At least 20 percent of elementary school-age children develop tics such as excessive blinking, throat clearing or sniffing, but for most of those kids, the tics don’t become a long-term problem. Conventional wisdom has held that most tics go away on their own and that only in rare cases do they become chronic or develop into a disorder such as Tourette syndrome.

However, studying children shortly after tics first appear, researchers at Washington University School of Medicine in St. Louis discovered that tics don’t go away completely; rather, most children simply exhibit tics less when others are watching. Learning how they do that may provide insight to help others at risk for significant tic disorders.

The findings are published online June 26 in the Journal of Child Neurology.

“We found that tics were still present one year after they first appeared but that many of the kids we studied had figured out how to suppress them,” said principal investigator Kevin J. Black, MD, a professor of psychiatry. “Uncovering just how they are able to control these tics may help other children do the same and perhaps avoid chronic tic disorders such as Tourette syndrome.” Chronic tic disorders affect about 3% of the population, he added.

The researchers examined 45 children who had just started experiencing some sort of tic. The kids were ages 5 to 10, with an average age of about 7 ½.

Thirty of the children were boys — in whom tic disorders are more common — and the other 15 were girls. All of the children were examined within a few months of when their tics first appeared, and a second time 12 months after the tics had started.

“Our expectation, initially, was that maybe one in 10 kids would still have tics at their follow-up exams,” said first author Soyoung Kim, PhD, a postdoctoral research associate in psychiatry. “Most had improved a year later, but to our surprise in every case, the children still had tics — many of them just controlled them better.”

Kim, Black and their colleagues verified the presence of tics by leaving each child alone in a room with a video camera. They found it was possible for most children to suppress tics when they were being watched during neurological exams. But when left alone, the children exhibited tics, without exception.

“I find tics fascinating because they illustrate the interplay between what is volitional and what is involuntary,” Black said. “People don’t tic on purpose, and most can suppress it for a short period of time, but at some point, it’s going to come out.”

The research team was able to identify several factors that predicted problematic tics at the one-year mark, as well as factors related to the ability to suppress tics.

A history of anxiety disorder was among the predictors of an inability to control or suppress tics, as was having pronounced tics during the kids’ initial exams. Having three or more vocal tics, such as throat clearing or making other noises, also indicated likelihood of evident tics one year later.

This shows faces drawn on balloons

Studying children shortly after they began experiencing tics, researchers at Washington University School of Medicine in St. Louis discovered that although tics don’t go away, most children are able to suppress and control them. Understanding how they do that may provide insight to help others at risk for significant tic disorders. The image is credited to Michael Worful.

In addition, children with higher scores on the Social Responsiveness Scale — a test that measures behaviors on the autism spectrum — also were likely to have continued problems with tics a year after first experiencing them.

“None of these kids had autism, but those who did a little bit worse on that test, who had what we would call sub-syndromal symptoms of autism, were more likely to have trouble with tics one year later,” Black said.

The researchers used a reward system to help determine whether the children could suppress tics. In one study exercise, they rewarded children with a token worth a few pennies for every 10 seconds they could go without having a tic. Those who suppressed their tics most effectively in response to rewards exhibited fewer and less significant problems at their follow-up visits.

“My suspicion is that, over time, these kids may improve in their ability to suppress tics, just from social cues,” Black said. “But perhaps more importantly, early on — when they’ve experienced tics for only a few weeks or months — some children already can suppress them. If we can develop ways to help other children acquire those skills, we might improve quality of life for those who otherwise may go on to develop a chronic tic disorder such as Tourette syndrome.”

Funding: These studies were supported by the National Institute Mental Health, the National Institute of Neurological Disorders and Stroke, and the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health (NIH). Grant numbers K24 MH087913, R21 NS091635, K01 MH104592, R01 MH104030, UL1 TR000448, U54 HD087011. A grant from the National Center for Research Resources also provided support for the work published in Scientific Reports, grant number UL1 RR024992.

About this neuroscience research article

Source:
WUSTL
Media Contacts:
Jim Dryden – WUSTL
Image Source:
The image is credited to Michael Worful.

Original Research: Open access
“Tic suppression in children with recent-onset tics predicts 1-year tic outcome”. Kim S, Greene DJ, Robichaux-Viehoever A, Bihun EC, Killer JM Acevedo H, Schlaggar BL, Black KJ.
Journal of Child Neurology. doi:10.1177/0883073819855531

Open access
“Provisional Tic Disorder is not so transient”. Soyoung Kim, Deanna J. Greene, Emily C. Bihun, Jonathan M. Koller, Jacqueline M. Hampton, Haley Acevedo, Angela M. Reiersen, Bradley L. Schlaggar & Kevin J. Black
Scientific Reports. doi:10.1038/s41598-019-40133-4

Abstract

Tic suppression in children with recent-onset tics predicts 1-year tic outcome

Successful voluntary tic suppression is a key component of the behavioral interventions that are used to treat tic disorders. This study aimed to examine tic suppression in children with recent-onset tics and determine whether the capacity to suppress tics predicts future tic severity. We tested 45 children (30 male, mean age 7.74 years) with recent-onset tics (mean 3.47 months prior to the first study visit; baseline) and re-examined each child at the 12-month anniversary of the first recognized tic (follow-up). At the baseline visit, children performed a tic suppression task with several conditions: tic freely, inhibit tics given a verbal request, and inhibit tics in the presence of a reward. At the baseline visit, children with tics for only a few months could suppress their tics, and tic suppression was especially successful when they received an immediate and contingent reward. Additionally, the ability to suppress tics in the presence of a reward predicted tic severity at follow-up. These findings suggest that better inhibitory control of tics within months of tic onset may be an important predictor of future tic symptom outcome.

Abstract

Provisional Tic Disorder is not so transient

Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. The present study was designed to prospectively assess outcome of children with what the current nomenclature calls Provisional Tic Disorder. We identified 43 children with recent onset tics (mean 3.3 months since tic onset) and re-examined 39 of them on the 12-month anniversary of their first tic. Tic symptoms improved on a group level at the 12-month follow-up, and only two children had more than minimal impairment due to tics. Remarkably, however, tics were present in all children at follow-up, although in several cases tics were apparent only when the child was observed remotely by video. Our results suggest that remission of Provisional Tic Disorder is the exception rather than the rule. We also identified several clinical features present at the first examination that predict one-year outcome; these include baseline tic severity, subsyndromal autism spectrum symptoms, and the presence of an anxiety disorder.

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