Summary: Exposure to nitrogen dioxide and nitrogen oxides through air pollution is linked to an increased risk of experiencing psychotic symptoms in teenagers. Accounting for other known risk factors, exposure to both NO2 and NOx accounted for 60% of the link between symptoms of psychosis and living in an urban environment.
Source: King’s College London
Research from King’s College London provides the first evidence of an association between air pollution and psychotic experiences in adolescence.
The study, published in JAMA Psychiatry, provides a potential explanation for why growing up in cities is a risk factor for psychosis. This is the first time researchers have linked detailed geographical air pollution data with a representative sample of young people across the UK.
Psychotic experiences, such as hearing voices and intense paranoia, are less extreme forms of symptoms experienced by individuals with a psychotic disorder like schizophrenia. While psychotic experiences are more common in adolescence than adulthood, young people who report psychotic experiences are more likely to go on to develop psychotic disorders, as well as a range of other mental health problems and suicide attempts.
The researchers found that psychotic experiences were significantly more common among adolescents with the highest exposure to nitrogen dioxide (NO2), nitrogen oxides (NOx), and very small particulate matter (PM2.5), even after accounting for known risk factors for psychosis. NO2 and NOx together accounted for 60% of the association between living in an urban environment and having adolescent psychotic experiences.
Lead author Dr. Joanne Newbury, from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) who is funded by the Economic and Social Research Council, says: ‘We found that adolescent psychotic experiences were more common in urban areas. While the study could not show pollutants caused adolescents to have psychotic experiences, our findings suggest that air pollution could be a contributing factor in the link between city living and psychotic experiences.’
Senior author Dr. Helen Fisher, from the IoPPN, says: ‘Psychotic disorders are difficult to treat and place a huge burden on individuals, families, health systems and society more broadly. By improving our understanding of what leads to psychotic experiences in adolescence, we can attempt to deal with them early and prevent people from developing psychotic disorders and other serious mental health problems.’
The research used data from the E-Risk study, funded by the Medical Research Council, which comprises 2232 children born in England and Wales. Young people were assessed for psychotic experiences in private interviews at age 18, responding to questions such as ‘do you hear voices that others cannot?’ and ‘have you ever thought you were being watched, followed or spied on?’.
The data on psychotic experiences were linked with hourly estimates of air pollution at 20×20 meter grid points throughout the UK, funded by a grant from the Natural Environment Research Council, Medical Research Council, and the Chief Scientist Office. Combining home addresses with two additional locations where the young people spent substantial amounts of time at age 17 meant the researchers could accurately model their exposure to air pollution over the space of a year.
Co-author Professor Frank Kelly, Professor of Environmental Health at King’s, says: ‘Children and young people are most vulnerable to the health impacts of air pollution owing to the juvenility of the brain and respiratory system. Given that 70% of the world’s population will live in cities by 2050, uncovering the mechanisms linking the urban environment to psychosis should be an urgent health priority. Analyzing the health impacts of air pollution is a core component of King’s civic responsibility.’
As the data in the study was taken at one point in time, the researchers say studies which track the association between air pollution and psychotic experiences over longer periods of time are needed. More work also needs to be done to understand if there are biological mechanisms linking air pollution to adolescent psychotic experiences and to rule out potential confounding factors like noise pollution.
About this neuroscience research article
Source: King’s College London Media Contacts: Joanne Newbury – King’s College London Image Source: The image is adapted from the King’s College London news release.
Importance Urbanicity is a well-established risk factor for clinical (eg, schizophrenia) and subclinical (eg, hearing voices and paranoia) expressions of psychosis. To our knowledge, no studies have examined the association of air pollution with adolescent psychotic experiences, despite air pollution being a major environmental problem in cities.
Objectives To examine the association between exposure to air pollution and adolescent psychotic experiences and test whether exposure mediates the association between urban residency and adolescent psychotic experiences.
Design, Setting, and Participants The Environmental-Risk Longitudinal Twin Study is a population-based cohort study of 2232 children born during the period from January 1, 1994, through December 4, 1995, in England and Wales and followed up from birth through 18 years of age. The cohort represents the geographic and socioeconomic composition of UK households. Of the original cohort, 2066 (92.6%) participated in assessments at 18 years of age, of whom 2063 (99.9%) provided data on psychotic experiences. Generation of the pollution data was completed on October 4, 2017, and data were analyzed from May 4 to November 21, 2018.
Exposures High-resolution annualized estimates of exposure to 4 air pollutants—nitrogen dioxide (NO2), nitrogen oxides (NOx), and particulate matter with aerodynamic diameters of less than 2.5 (PM2.5) and less than 10 μm (PM10)—were modeled for 2012 and linked to the home addresses of the sample plus 2 commonly visited locations when the participants were 18 years old.
Main Outcomes and Measures At 18 years of age, participants were privately interviewed regarding adolescent psychotic experiences. Urbanicity was estimated using 2011 census data.
Results Among the 2063 participants who provided data on psychotic experiences, sex was evenly distributed (52.5% female). Six hundred twenty-three participants (30.2%) had at least 1 psychotic experience from 12 to 18 years of age. Psychotic experiences were significantly more common among adolescents with the highest (top quartile) level of annual exposure to NO2 (odds ratio [OR], 1.71; 95% CI, 1.28-2.28), NOx (OR, 1.72; 95% CI, 1.30-2.29), and PM2.5 (OR, 1.45; 95% CI, 1.11-1.90). Together NO2 and NOx statistically explained 60% of the association between urbanicity and adolescent psychotic experiences. No evidence of confounding by family socioeconomic status, family psychiatric history, maternal psychosis, childhood psychotic symptoms, adolescent smoking and substance dependence, or neighborhood socioeconomic status, crime, and social conditions occurred.
Conclusions and Relevance In this study, air pollution exposure—particularly NO2 and NOx—was associated with increased odds of adolescent psychotic experiences, which partly explained the association between urban residency and adolescent psychotic experiences. Biological (eg, neuroinflammation) and psychosocial (eg, stress) mechanisms are plausible.