The Ways of Wisdom in Schizophrenia

Summary: A new study reveals a correlation between higher levels of wisdom in those with schizophrenia and general well-being, better cognitive performance and everyday function.

Source: UCSD.

While wisdom is closely linked to improved health and well-being, its role and impact among persons with schizophrenia, possibly the most devastating of mental illnesses, is not known.

In a new paper, published February 14, 2019 in Schizophrenia Research, researchers at University of California San Diego School of Medicine report that, on average, persons with schizophrenia (PwS) obtained lower scores on a wisdom assessment than non-psychiatric comparison participants (NPCPs), but that there was considerable variability in levels of wisdom. Nearly one-third of PwS had scores in the “normal” range, and these PwS with higher levels of wisdom displayed fewer psychotic symptoms as well as better cognitive performance and everyday functioning.

“Taken together, our findings argue for the value of assessing wisdom in persons with schizophrenia because increasing wisdom may help improve their social and neuro-cognition, and vice versa,” said senior author Dilip Jeste, MD, Distinguished Professor of Psychiatry and Neurosciences and director of the Stein Institute for Research on Aging at UC San Diego School of Medicine.

“There is a concept of ‘wellness within illness,’” said Jeste. “Our findings support the hypothesis that wisdom and schizophrenia co-exist in a proportion of these patients, specifically those functioning at a higher level. Furthermore, the data suggest that treatments which enhance positive psychological traits, such as wisdom, may promote health and well-being in persons with schizophrenia.

“We have a tendency in medicine to focus attention on remediating symptoms and impairments to the exclusion of individual strengths. A sustained effort to assess and enhance positive traits in a person with severe mental illness, such as their levels of wisdom, happiness and resilience, might do much to improve the quality of their lives.”

In this study, 65 stable adult outpatients with a diagnosis of chronic schizophrenia or schizoaffective disorder and 96 NPCPs completed a commonly used, three-dimensional wisdom scale (3D-WS) that includes measures of cognitive, reflective, and affective (relating to emotion) wisdom.

While people with schizophrenia had lower average scores on the wisdom scale than NPCPs, those PwS with higher wisdom scores performed better on neurocognitive and functional assessments than those with lower scores. Indeed, level of wisdom positively correlated with performance on multiple neurocognitive tests in PwS; no such relationships were detected in NPCPs.

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The researchers also found that the reflective domain of wisdom — the ability to look inward accurately and without bias or to recognize others’ perspectives — was significantly related to the mental health and well-being of PwS, while levels of cognitive and affective wisdom appeared to have no such correlative effect. NeuroscienceNews.com image is in the public domain.

The researchers also found that the reflective domain of wisdom — the ability to look inward accurately and without bias or to recognize others’ perspectives — was significantly related to the mental health and well-being of PwS, while levels of cognitive and affective wisdom appeared to have no such correlative effect.

“In healthy adults, wisdom seems to reduce the negative effects of adverse life events. It boosts a sense of well-being, life satisfaction and overall health,” said first author Ryan Van Patten, a postdoctoral scholar in the UC San Diego School of Medicine Department of Psychiatry. “In persons with schizophrenia, wisdom is also connected to levels of happiness, resilience, and subjective recovery.”

In recent years, there has been increasing empirical evidence that wisdom has a biological basis and can be modified and enhanced through a variety of interventions. This study, said Jeste, supports the idea that therapies which promote wise behavior in persons with schizophrenia can also boost their broader capacity to function in society, more healthfully and with greater happiness and satisfaction.

About this neuroscience research article

Funding: Funding for this research came, in part, from the National Institutes of Health (R01MH094151-01), the National Institute of Mental Health (MH019934) and the Stein Institute for Research on Aging at UC San Diego.

Source: Scott LaFee – UCSD
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Assessment of 3-dimensional wisdom in schizophrenia: Associations with neuropsychological functions and physical and mental health” by Ryan Van Patten, Ellen E. Lee, Rebecca Daly, Elizabeth Twamley, Xin M. Tu, and Dilip V. Jeste in Schizophrenia Research. Published February 14 2019.
doi:10.1016/j.schres.2019.01.022

Cite This NeuroscienceNews.com Article
UCSD”The Ways of Wisdom in Schizophrenia.” NeuroscienceNews. NeuroscienceNews, 16 February 2019.
<http://neurosciencenews.com/schizophrenia-wisdom-10753/>.
UCSD(2019, February 16). The Ways of Wisdom in Schizophrenia. NeuroscienceNews. Retrieved February 16, 2019 from http://neurosciencenews.com/schizophrenia-wisdom-10753/
UCSD”The Ways of Wisdom in Schizophrenia.” http://neurosciencenews.com/schizophrenia-wisdom-10753/ (accessed February 16, 2019).

Abstract

Assessment of 3-dimensional wisdom in schizophrenia: Associations with neuropsychological functions and physical and mental health

Recent decades have seen growing empirical research in wisdom as a complex, trait-based psychological characteristic. Wisdom has been shown to possess individual and societal benefits through associations with health and well-being, but it has not yet been evaluated in people with schizophrenia (PwS). In the current study, we administered a widely used, validated 3-dimensional wisdom scale that includes three interrelated dimensions: cognitive, reflective, and affective. We examined group differences in wisdom, as well as relationships between wisdom and sociodemographics, clinical symptoms, neurocognitive and functional performance, and mental and physical health in 65 stable adult outpatients with chronic schizophrenia or schizoaffective disorder and 96 non-psychiatric comparison participants (NPCPs). Results showed that PwS had lower wisdom scores than NPCPs and that wisdom moderated relationships between diagnostic group and neurocognitive and functional performance; PwS with higher levels of wisdom demonstrated better cognitive performance than did PwS with lower levels of wisdom. In addition, wisdom was positively correlated with performances on multiple neurocognitive tasks in PwS, but not in NPCPs. Finally, reflective wisdom – representing accurate/unbiased introspection and perspective-taking – correlated with all mental health variables in PwS. Our results were limited by a cross-sectional design, but suggest that wisdom, especially reflective wisdom, may be associated with better cognitive performance and better physical and mental health in PwS. It is conceivable that interventions to enhance wisdom may have broad cognitive and mental and physical health benefits in individuals with chronic psychotic disorders.

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