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Pregnancy Changes Perception of Tastes and Odors

Receptor modifies how mated fruit flies perceive polyamines.

The perception and reactions to odours and tastes can change in pregnancy, sometimes dramatically. This is also true for flies. The mechanisms, however, that trigger these changes are not understood in either mammals or insects. Scientists from the Max Planck Institute of Neurobiology in Martinsried now succeeded in demonstrating that the concentration of a certain receptor increases in the sensory organs of gravid fruit fly females. As a result, the taste and odour of important nutrients, called polyamines, are processed differently in the brain: Pregnant flies favour nutrition that is rich in polyamines and increase their reproductive success in this way.

A pregnancy represents a huge challenge for the mother’s body. To provide optimal nutrition for the developing offspring, her nutrition must be adapted to the altered requirements. “We wanted to find out whether and how expectant mothers can sense the nutrients they need,” explains Ilona Grunwald Kadow, Research Group Leader at the Max Planck Institute of Neurobiology.

Polyamines are nutrients that can be produced by both the body itself and by intestinal bacteria. However, some of the polyamines needed must be obtained from food. With advancing age, the consumption of polyamines through food increases in importance, as the body’s own production declines. Polyamines play a role in numerous cell processes and a polyamine deficiency can have a negative impact on health, cognition, reproduction and life expectancy. An excess of polyamines can also be harmful, however. The intake of polyamines should therefore be adapted to the body’s current needs.

The Max Planck neurobiologists now succeeded in demonstrating that, after mating, female fruit flies show a preference for food with a high polyamine content. A combination of behavioural studies and physiological tests revealed that the change in the appeal of polyamines to flies before and after mating is triggered by a neuropeptide receptor known as the sex peptide receptor (SPR) and its neuropeptide binding partner. “It was already known that the SPR boosts egg production in mated flies,” explains Ashiq Hussain, one of the study’s two first authors. “But we were surprised to discover that the SPR also regulates the activity of the sensory neurons that recognize the taste and smell of polyamines.”

Considerably more SPR receptors are integrated into the surfaces of the chemosensory neurons in pregnant females. This increase in neuropeptide signalling modifies the reaction of the sensory neurons to the odour and taste. The thereby intensified odour and taste perception thus occurs at a very early stage in the nervous system. The importance of the receptor became clear when the researchers increased the presence of SPRs in the olfactory and taste neurons of virgin females, using a genetic tool: This change was sufficient to enable the neurons of the virgin flies to react more strongly to polyamines, which ultimately resulted in a change of their preference. Like their mated species counterparts, virgins now preferred the polyamine-rich food sources.

Image shows part of the reproductive system with the uterus of the female fly.

The reproductive state of the female fly sends signals to the brain, after which the sensory perception changes. The image shows part of the reproductive system with the uterus of the female fly. Credit: MPI of Neurobiology/ Friedrich.

The study demonstrated, for the first time, the existence of a mechanism through which pregnancy modifies specific chemosensory neurons and alters the perception of important nutrients and behaviour towards them. “Because smell and taste are processed in a similar way in insects and mammals, a corresponding mechanism in humans could also ensure an optimal nutritional supply for the developing life,” presumes Habibe Üc̗punar, second first author of the study. In a concurrently published study, the scientists were also able to demonstrate how the important polyamines are actually sensed and evaluated by the fruit flies.

About this neuroscience research

Source: Dr. Stefanie Merker – Max Planck Institute
Image Source: The image is credited to MPI of Neurobiology/ Friedrich.
Original Research: Full open access research for “Neuropeptides modulate female chemosensory processing upon mating in Drosophila” by Ashiq Hussain, Habibe K. Üçpunar, Mo Zhang, Laura F. Loschek, and Ilona C. Grunwald Kadow in PLOS Biology. Published online May 4 2016 doi:10.1371/journal.pbio.1002455


Abstract

Neuropeptides modulate female chemosensory processing upon mating in Drosophila

A female’s reproductive state influences her perception of odors and tastes along with her changed behavioral state and physiological needs. The mechanism that modulates chemosensory processing, however, remains largely elusive. Using Drosophila, we have identified a behavioral, neuronal, and genetic mechanism that adapts the senses of smell and taste, the major modalities for food quality perception, to the physiological needs of a gravid female. Pungent smelling polyamines, such as putrescine and spermidine, are essential for cell proliferation, reproduction, and embryonic development in all animals. A polyamine-rich diet increases reproductive success in many species, including flies. Using a combination of behavioral analysis and in vivo physiology, we show that polyamine attraction is modulated in gravid females through a G-protein coupled receptor, the sex peptide receptor (SPR), and its neuropeptide ligands, MIPs (myoinhibitory peptides), which act directly in the polyamine-detecting olfactory and taste neurons. This modulation is triggered by an increase of SPR expression in chemosensory neurons, which is sufficient to convert virgin to mated female olfactory choice behavior. Together, our data show that neuropeptide-mediated modulation of peripheral chemosensory neurons increases a gravid female’s preference for important nutrients, thereby ensuring optimal conditions for her growing progeny.

“Neuropeptides modulate female chemosensory processing upon mating in Drosophila” by Ashiq Hussain, Habibe K. Üçpunar, Mo Zhang, Laura F. Loschek, and Ilona C. Grunwald Kadow in PLOS Biology. Published online May 4 2016 doi:10.1371/journal.pbio.1002455

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