Pain Relief Without Side Effects and Addiction

Summary: Researchers have developed a new substance that activates adrenalin receptors rather than opioid receptors to help relieve chronic pain. The new compounds have similar pain-relieving qualities as opioids but do not appear to induce respiratory depression or addiction.

Source: Friedrich-Alexander-Universität Erlangen-Nürnberg

New substances that activate adrenalin receptors instead of opioid receptors have a similar pain-relieving effect to opiates, but without the negative aspects such as respiratory depression and addiction.

This is the result of research carried out by an international team of researchers led by the Chair of Pharmaceutical Chemistry at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU).

Their findings, which have now been published in the renowned scientific journal Science, are a milestone in the development of non-opioid pain relief.

Opiates cause addiction, new substances do not

They are a blessing for patients suffering from severe pain, but they also have serious side effects: Opioids, and above all morphine, can cause nausea, dizziness and constipation and can also often cause slowed breathing that can even result in respiratory failure.

In addition, opiates are addictive – a high percentage of the drug problem in the USA is caused by pain medication, for example.

In order to tackle the unwanted medical and social effects of opioids, researchers all over the world are searching for alternative analgesics.

Prof. Dr. Peter Gmeiner, Chair of Pharmaceutical Chemistry is one of these researchers. “We are focusing particularly on the molecular structures of the receptors that dock onto the pharmaceutical substances”, says Gmeiner.

“It is only when we understand these on the atomic level that we can develop effective and safe active substances.”

Collaborating with an international team of researchers, Prof. Gmeiner discovered an active substance in 2016 that bonds to known opioid receptors and that offers the same level of pain relief as morphine, even though it has no chemical similarity to opiates.

New approach: Adrenaline receptors instead of opioid receptors

Peter Gmeiner is currently following a lead that seems very promising: “Many non-opioid receptors are involved in pain processing, but only a small number of these alternatives have as yet been validated for use in therapies”, he explains.

Gmeiner and a team of researchers from Erlangen, China, Canada and the USA have now turned their attention to a new receptor that is responsible for binding adrenaline – the alpha 2A adrenergic receptor. There are already some analgesics that target this receptor such as brimonidine, clonidine and dexmedetomidine.

Gmeiner: “Dexmedetomidine relieves pain, but has a strong sedative effect, which means its use is restricted to intensive care in hospital settings and is not suitable for broader patient groups.”

The aim of the research consortium is to find a chemical compound that activates the receptor in the central nervous system without a sedative effect. In a virtual library of more than 300 million different and easily accessible molecules, the researchers looked for compounds that physically match the receptor but are not chemically related to known medication.

This shows a woman in pain
The aim of the research consortium is to find a chemical compound that activates the receptor in the central nervous system without a sedative effect. Image is in the public domain

After a series of complex virtual docking simulations, around 50 molecules were selected for synthesis and testing and two of these fulfilled the desired criteria. They had good bonding characteristics, activated only certain protein sub-types and thus a very selective set of cellular signal pathways, whereas dexmedetomidine responds to a significantly wider range of proteins.

Pain relief without sedation in animal models

By further optimizing the identified molecules, for which extremely high-resolution cryo-electron microscopic imaging was used, the researchers were able to synthesize agonists that produced high concentrations in the brain and reduced the sensation of pain effectively in investigations with animal models.

“Various tests confirmed that docking on the receptor was responsible for the analgesic effect,” explains Gmeiner. “We are particularly pleased about the fact that none of the new compounds caused sedation, even at considerably higher doses than those that would be required for pain relief.”

The successful separation of analgesic properties and sedation is a milestone in the development of non-opioid pain medication, especially as the newly-identified agonists are comparatively easy to manufacture and administer orally to patients.

However, Prof. Gmeiner has to dampen any hopes of rapid widespread use in human medicine: “We are currently still talking about basic research. The development of medication is subject to strict controls and in addition to significant amounts of funding, it takes a long time. However, these results still make us very optimistic.”

About this neuropharmacology and pain research news

Author: Katrin Piecha
Source: Friedrich-Alexander-Universität Erlangen-Nürnberg
Contact: Katrin Piecha – Friedrich-Alexander-Universität Erlangen-Nürnberg
Image: The image is in the public domain

Original Research: Closed access.
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor” by Peter Gmeiner et al. Science


Abstract

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α2A-adrenergic receptor (α2AAR), seeking new α2AAR agonists chemotypes that lack the sedation conferred by known α2AAR drugs, such as dexmedetomidine.

We identified 17 ligands with potencies as low as 12 nanomolar, many with partial agonism and preferential Gi and Go signaling. Experimental structures of α2AAR complexed with two of these agonists confirmed the docking predictions and templated further optimization.

Several compounds, including the initial docking hit ‘9087 [mean effective concentration (EC50) of 52 nanomolar] and two analogs, ‘7075 and PS75 (EC50 4.1 and 4.8 nanomolar), exerted on-target analgesic activity in multiple in vivo pain models without sedation.

These newly discovered agonists are interesting as therapeutic leads that lack the liabilities of opioids and the sedation of dexmedetomidine.

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  1. Renee Poppers;
    Apologize I guess I miss-understood. I too take injections, but even with these corticosteroid injections, I still suffer so much. Also the injections last only 3 months and you’re not allowed more than 3 per year due to the damaging effects on our bones (although it still effects our bones but not is not as extreme). Bottom line, everyone is different and I do understand the fears of people overdosing. For instance I had a friend who knew someone who suffered pain and received much medication. The thing is he was not being monitored for levels in his system and he’d be out one week after getting these drugs and need to wait 3 weeks to refill. That is not pain, that’s addiction. On top of this he was in and out of the hospital suffering from overdosing. It was a pathetic story but a true one. The ones who really need it get pushed back because of people like this guy. There is a long history with Him of abuse and yet to this day he still receives pain medication!! Doctors need to run drug testing to check levels of the medication being prescribed. End of story.

  2. Idgaf what the doctors bullshit excuses are anymore! Constant pain makes life unbearable, and taking away the only relief is barbaric! You don’t really care that you “might” become addicted,,when every minute of everyday all you can think about is the pounding pain your in!! If the doctors don’t pull the heads outta their asses,,,suicide will become the number 1 cause of death worldwide,,,it’s not life,,,it’s not worth living when you have to feel unbearable pain with every beat of your heart! The doctors that think they are helping,,,are killing those of us in pain everyday,,,, here,,let me take a hammer to a finger,,,every minute of the day for the rest of your life,,and let’s see how long you wanna live! Fucking stupid bullshit,,,it’s common sense,,,STOP MAKING PEOPLE SUFFER! Until they would rather die!!! DUH!!!

    1. I have been going thru this for 20 years now
      I totally agree with Denise
      No one, including government, doctors or any other affiliation who has not or does not experience this debilitating,
      Life interference in every form .
      Terribly destroying families with inability to function in normal everyday relationships!
      Doctors have sent me through the mill, and only to seek the $$ as Their recommended treatments have no benefit, and pain clinics demand steroid shots by anesthesiologist, which, for me had absolutely no effect for pain relief and Have caused more diseases and pain in my body!
      They have no idea what this pain feels like. They might be book smart but have no clue of how we feel in our body.

  3. Every time they come out with something new for pain they always say it’s not addictive. But it always is and it always will be abused. Never trust the pharmaceutical companies.i.e. Purdue pharma

  4. What do I say to this. A surgeon messed my back up when he did a 360 spinal fusion. Cut me front and back in one surgery. I really wanted it to work. Surgery was done in 1997. By 1999 I knew something was wrong. By 2003 they found a pedicle screw in my spinal nerve boy the damage both SI joints unstable. Was on opioids from that day forward took them like I was supposed to. I have a doctor friend that told me that they are told to treat everyone as a drug addict. I couldn’t believe what he said I asked my pain doctor this and he verified it. Addiction is a evil beast. I still take a opioid and hydrocodone for break through. By the first of the year he wants to take me off them and put me on something else almost like Suboxone I guess. I had my third back surgery in n March and December I will have another surgery to stabilize both my SI joints. I am 65 now. I wish I never had the first one. People in pain do not have much of a life. God be with us all

    1. I am 44 and haven’t got any relief for my ongoing pain due to m.s. I have been on everything from vicodin, oxycodone,fentanyl patch and NOTHING WORKS ! I am at my wits end..what else is out there ???
      I am bedridden due to m.s. & bad knees for 6 yrs. Won’t ever be able to go anywhere except to Doctors appointments, in the back of an ambulance. Live is supposed to be livable in my case why bother. The pain is 24/7 I’m not sure their is anything left to help except when I cease to breathe…God willing that will be sooner than later !!!

  5. Statements like this are so corrosive to the Chronic Pain community.

    “In addition, opiates are addictive – a high percentage of the drug problem in the USA is caused by pain medication, for example.”

    I am am so angry and insulted that these supposed doctors blame the chronic pain community for the opioid problem. I AM NOT THE CRIMINAL!!!

    I’ve had 24 surgeries, arthritis and peripheral neuropathy (non diabetic)and had been on opioids for 20+ years. I am no longer seen by the Rheumatologist because osteoarthritis is not the right kind of arthritis. My neurologist was forced to retire and my GP would not prescribe opioids. Have been on disability for 10 years and I have no quality of life now that I am reduced to 800mgs IBU’S 3X’s a day, Gabapentin and Cymbalta.

    I have no faith in the medical community and feel the CDC should be charged with murder for all the chronic pain patients that have taken their lives because they had no alternative. Also, they should be investigated for the falsified numbers of opioid overdoses. While at the CDC must be held liable for the pain and suffering inflicted on the chronic pain community.

  6. Something needs to be done to help the people who are suffering from severe chronic pain. I have been in pain now for just over 20 years, I was all the way up to taking MS Contin when they decided to take the pain relief away from EVERYONE. They now put everyone on a Butrans patch(buprenorphine) which is supposed to be the equivalent to morphine and worn for 7 days at a time. Which I have been wearing those for almost 5 years now. So what are they going to prescribe me next when my body has hit it’s tolerance? Which it seems it has because I am still in debilitating pain daily. I have no life anymore, and I’m only 52 years old. You can damn well bet the doctors that have any chronic pain issues have no problems getting the medication they need…….

    1. I get it because I am hurting too. I have refused to take pain pills because in my opinion addiction would be worse than what I’m going thru. Having to take more & more for them to continue to work….no way!! I’ve never been to a pain clinic & was referred because I thought they just pushed pain pills. I decided to go just to see & made it clear I did not want any controlled substance. Best decision ever….. I still hurt but nothing like it was. I can function. They put me on the dose of my meds that actually work for me. Changed a few. I had steroid injections. If something they do doesn’t work, I tell them & they come up with the next step. Yes, it sounds like a lot compared to just popping a pill…. But this longer road I’m taking to help my issues is working & is not creating a new and worse problem such as addiction.
      I’m sorry your in pain & I’m sure it’s hard being started with pain pills & then them being taken away. I hope you get something to stop your pain.

      1. Rene Poppers
        I have got to say this to you. If you can function and work without any intervention, than my dear I’m very sorry but your on the wrong board and in the nicest way I can say this that’s not true debilitating pain we’re speaking about, that’s just little aches and pains. There IS NO WAY to just DEAL WITH IT. But thank you nonetheless for your 2 cents.

  7. It will be the same as opioids. You have to go thru all the same tests to get them get frowned on for needing them. Its not bad nuff that now I’m stuck in Suboxone. Now this. I know I don’t have to try them no one does. So they scare everyone to. Death from look alikes n then want to try something new. They can keep it all. I will live this way forever. Tylenol and Suboxone. They say that works . No it’s a pill to rid you if addiction yet it’s also addiction makes no sense to me none of it!!!

  8. Why in the hell are we leting a few hundred bad doctors out of a million in the United States dictate policy for pain management just like the police are letting a few bad cops dictate the crime in America! We better get back to common Sense and logic because America is going down a bad rabbit hole it’s time to get new leaders and take our country back! It’s almost like we’re in a bad episode of The twilight zone enough is enough!

    1. I have been on opioid pain meds for over 5 years. There is tolerance, so at times they aren’t as effective
      Add to that use of Movantik for relief of opioid induced constipation. Works well, sometimes too well. The problem with Movantik is one side effect is mild withdrawal symptoms. So it’s sort of a daily catch 22. As for potential abuse of such medication, I am fortunate to be an addict/alcoholic in recovery since 4/4/90. It’s, for me a case of, been there done that (I V heroin addict in the 60’s, and 70’s), and attend AA and CA meetings on a regular basis, 4-7, a week. Thank You Jimmy Paolino.

  9. Your wrong kept that opinion to yourself. My pain started at age 36 I am know 66 I was on pain meds they took me off at 57 when all the addiction mess started I took them as prescribed but still the government like everything else the need to control us its mind bogling how they think to know each an everyone of us so now is very difficult an painful trying to live what time I have left with my grandchildren an my kids an all this could have been avoided.

  10. Please bring any pain relief asap. And consider me for trial as I would love to be a productive human again, my mind wants to be working 24/7 but my pain level won’t allow me. I see help signs for job opening and wish and need the finacial help as a senior.

  11. Have battled chronic pain for many yrs been on opioids for many yrs. Not much help am at my wits end don’t like side effects of opiates.

  12. I am Praying for relief from pain for all of you. I have suffered from pain for 20 years now. Tried everything. 2 bad car accidents, 5 screwed up r knee replacements almost died from infections 5 staff bugs for 3 years l am diabetic. After all of these failed r knee replacements l got Fibromyalgia. Pain just can’t be controlled. Been in pain therapy for 6 to 7 years. All a big waste of money no help. Feb this year l fell was knocked out found after 6 to 7 days was in a coma in hospital for 5 months.l had to learn all over to learn to walk
    Hardest thing l ever had to do. Long recovery l ws on vivodine,morphine,Flexeril,soma, perkaset nothing touches my pain. I did get Oxycotin which slightly helped my all over pain. I was getting 5 or 6 10mg a day. Pain still bad now on 2 10mg a day. After fall got a huge pressure ulcer could fit 2 fits in it nurses said. Still slowly healing. I 🙏 that all of us can get Help and relief we need so we can try to live a normal life. I am60 years old now feel like l 100. God Bless you all.❤️

    1. I’m in the same situation,& have been for hmm,maybe 20 +yrs. !! I’ve also learned (a few years ago) that the “Dr.” I had been seeing for 10 yrs, was NOT even a Dr.!!! Police found patient files in a “commercial “ garbage disposal!! Sooo after that I have been to so many Dr.’s & clinics…it’s hideous!!! I’ve been on Suboxone for yrs now. I feel the same way as you!! I don’t understand why ppl with chronic pain can’t get proper treatment!! I pray that you, me, & anyone that suffers from pain can soon receive proper treatment 🙏!! Please know that I feel the same way 😭, but I’m praying for all of us🥰

    2. Jan I am extremely sorry to hear of your long-term struggle. Please know, there are people out here who are touched by your story, and who will be thinking of you and praying for you!

  13. Alpha 2A are adrenergic receptors specific for norepinephrine as a ligand not ‘adrenalin’ – massive difference.

    1. This site prints nothing but rubbish. There are so many innaccuracies, downright falsehoods and anti opiod propaganda I wouldnt know where to start. If it was in print it wouldnt be fit to line a birdcage!

  14. I have severe chronic pain with no quality of life. I was so happy when my pain was under control with opioids! They made me take them and now After 20 years of managing pain with opioids it’s obvious someone’s hididing them for a sports reason or entertainment. It’s ridiculous to kill of people of our own kind or any ! The families that have been destroyed because of jealousy or look alike they can arrest and give to a rich guy or whomever because they look like so they loved tha they lost. Take the money away from the idiots calling each other names like 2year olds and let it be run of common sense law. There is no justice system that is normal. Flinstone ages.USA needs to get it going on positive mode and think things are getting better and better every day.

  15. Modern doctors like to experiment with these new medications .every single one of them makes me extremely sick and hurts my kidneys .some of them make me hurt more. none of them work and it terrifies me that they may want to experiment on me more with newer stuff just like this in the future.

  16. Good day. I am diagnosed with rheumatoid arthritis,also had numerous surgeries.i would like to give this a try

  17. Jesus Christ this is sooooo scary because I’m suffering as I write with joint pains that wrote go away from a motorcycle accident!!! I really see there’s no way out of this other then to take your on life!!!I’m really shocked that so many Americans are going through the exact same thing I’m experiencing!!!

  18. When will this go to market? I have had excruciating chronic pain for over 30 years. I tried muscle relaxers and it felt like my respiratory system wanted to shut down. Marijuana even did the same thing to me. Addiction runs in my family so I’m afraid of many of the drugs on the market. I would love to try it myself.

  19. I am SO happy they are onto something that provides adequate pain relief without being addictive to certain people. Sadly, because I’m 67 years old, it will likely not come to fruition in my lifetime.

    I was disappointed that you echoed the false narrative by stating, “a high percentage of the drug problem in the USA is caused by pain medication.” This has now been proven false many times over. Opioid prescribing has been cut by 40% to 60% in the US (depending on the research and source), yet overdose rates have skyrocketed. Pain patients are not–and never were–the problem. It’s become clear that the government (CDC) wanted the public to think they were doing something about the drug problem and chose the easiest targets–pain patients and their doctors. The proof is there for all who want to see it. Yes–there is a certain population who have an addictive personality and are more at risk of abusing opioid pain medications, and if this future medication can help just one of these people and still provide pain relief, it will be welcome.

    I really wish you would have researched this claim in what otherwise is good and welcome information.

    1. I completely agree with you on this. And for those who’s meds got cut back, we are having a hard time. I don’t and would not buy anything from the streets! I know of friends and family who have lost a loved one, because they were either cut so low on the amount changed ( daily count ) that have tried to get relief from a seller and ended up dying from fentanyl! So sad

    2. Thank you for pointing out the facts – chronic pain patients are not the ones addicted to pain killers! I was going to complain about the article’s mischaracterization myself, glad you beat me to it. I’ve been using opiates for an amputation related neuroma for thirty years now, currently taking sublingual buprenorphine, and I’ve never had a problem with addiction or overdose. Dependence is normal, but is not at all the same as addiction.

  20. My husband suffers from incapacitating pain from neuropathy for several years now. He is only 58 yrs. old and has no quality of life. Please consider human trials, he is desperate for help.

  21. I am suffering pain continuous from innerstitial cystitis with hunner lesions. I have been with zero quality, of life for over 2 years. I am at the end of the treatments and my next try would be bladder removal this does not always fix the pain. I would love to try this medication. Help please.

    1. I am addicted to adrenaline. It’s a real thing called post traumatic stress syndrome. I fought in two wars, doctors called it “self destructive behavior”. I called it adrenaline seeking behavior. My body is paying the price for my youthful follies, but I’m still alive.

  22. An alternate to opioids will never be allowed to be legally produced and/or administered. Ibogaine effectively treats addiction to opioids, yet when it was put on the prescription drug list the Canadian government testing results on efficacy were in direct contradiction with the testing from scientists who developed it. This medication was working! They say, it doesn’t. Side effects too great, yet the only documented side effect was a mild rash that clears up in time. All the treatment centres were deemed illegal and shut down. Ibogaine may only be used in severe cases where death is imminent and all other treatment has been unsuccessful. The opioid crisis was not accidental, it was planned. The war on drugs was started to hide the potential healing properties of psychedelic drugs, to keep us obedient. The only pharmaceuticals allowed to be administered are the ones that treat, not cure the issue. Addiction is ok as long as it’s addiction to legalized drugs so they profit and we remain under control.

    1. You are absolutely right Georgie-Ann! It seems that in today’s society if you try to seek care for pain you become a outcast and start to become either avoided or looked down on more than someone that has a highly contagious disease. I have Charcot Marie Tooth disease. It attacks my lower legs to cause my muscle to deteriorate and severe Neuropathy and leads to developing compression wounds that won’t heal. One of those wounds contracted a serious staff infection and costed me my left leg over 10 years ago and now I have another wound developing on my right foot. Because of current regulations I can’t get the proper pain relief I need to try to have some kind of life. Instead I have to try to make do with what relief I can get from the addiction medicine and put up with people judging me and being made to feel like a outcast. It has left me disabled and took away from me any chance of a career and a lifestyle that I can never have. So if there is a trail for a medicine that might allow me some relief as I move into my golden years and be able to spend time with my grandchildren then I’m all for it. It’s not until people like us band together and use our voice to constantly protest to the officials who can change those restrictions and let other people know that we have been discriminated against long enough. Now days it seems like the only way you can be heard is if you are involved in a lawsuit so maybe everyone in pain should sue the people that’s not and let them have a little taste of pain in their life. Only then will the discrimination stop and we can make a difference for someone else before their lives are consumed with this.

  23. I am a 45-year-old male and broke my lower back when I was 17 and when I was in my early thirties I ruptured a disc in my upper the middle back I’ve been reinjured my my lower back again in my early thirties and my upwards and middle back for a second time I have been battling back pain for most of my life and only in the Last 5 Years my back pain has become almost embearable. I cannot take prescription opioids due to battling prescription opioid Addiction on and off for over 25 years so I’m basically left unable to treat my back pain so if this company is looking for people to use in human trials I would be one of the first to volunteer.

    1. I’m right there with you. I’m 67 and it’s highly unlikely these meds will be available in my lifetime, so I would LOVE to participate in any trial that may come up while I’m still on this earth. I’ve had multiple back and neck surgeries. I currently have 4 bulging lumbar discs, extensive arthritis, severe stenosis, and bone spurs. I also have a plate and rods that extend from my head into my upper back and recently learned there are 4 loose screws. I can’t describe the pains that shoot into my head and also into my shoulder and hand. One screw, in particular, is causing stroke-like symptoms. I get double-vision that sometimes lasts up to 2-3 days if I move my head slightly in a certain direction. The doctor says I need surgery NOW, but unfortunately, 3 surgeons told me that I’m no longer a candidate for surgery because I have so much metal in my neck that intubating me is too risky. What am I supposed to do? I’m already suffering, and the doctor acknowledged that the symptoms are going to get even worse. It seems that every week a new symptom crops up or a current symptom gets worse.

      1. Hey Gina , interesting! How did they find the screw was loose? Having some same issues you can private message if I like on fb Yvette Janney Hodges

  24. My dad had this pain in his face Dr treated it with a medication used for siezures and it went away. In your face is called a triamentic nerve. It can be fixed

  25. All medicine that relives pain can be addictive if a person has an addictive personality. Don’t blame the drug. It’s the person who is responsible for their addiction. I know of people who take Opiods at prescribed levels and do not abuse them at all.

    1. I’m sorry Kai, but you clearly have never spent a long period on opioid medication because if you had you would realise that there are two types of addiction, physical addiction and psychological addiction. Opioid medication causes the former given enough time on the medication in question, stopping the medication without very gradual step-down of the dosage causing serious and even life threatening withdrawal effects. This is due to the fact that the body begins to produce more mu-opioid receptors in order to better bind with the opioid medication, when you stop taking the medication, the receptors are starved and the body begins experiencing severe withdrawal symptoms – this has nothing to do with the patients personality and if they have an addictive personality or not, simply due to biochemistry and the effect of starving a body that has biochemically changed to better absorb and use the drug in question and the resultant change that is necessary to sneak that person’s biochemistry back to normal again when it is time to come off of the medication. Please therefore do not speak about something you have insufficient knowledge about in the first place, it is because of people like you that long term pain patients are denied the pain medication they need to live a relatively liveable life. As a long term pain patient myself (14 years) who has seen people who have not been as lucky as me to have a skilled pain team and a GP who isn’t afraid to prescribe long term despite the current climate of negativity towards long term opioid prescription, it is people like you that have resulted in those individuals not getting the pain relief they require and having to either fall back on the street equivalent or have been forced to take their own life because they simply could not handle the pain anymore. Think before you type in future please.

      1. You actually have insufficient knowledge and should educate yourself before typing. There is a HUGE difference between an addict and being physically dependent on medication. And it’s not just opioids that cannot be stopped abruptly–many others, including anti-seizure medications, heart medications, and diabetic medications also can’t be abruptly stopped because the body will undergo harmful withdrawal symptoms. I had been on and off high doses of pain meds for over 30 years and had never abused them or turned to the streets. You also either have no knowledge on “addictive personalities,” or you know someone who overdosed and don’t want to admit the person was an addict, although there is no shame in admitting this as it is a legitimate medical condition. Please educate yourself before you criticize someone who is obviously more knowledgeable than you.

      2. I can so relate to this response. I too have been on opioids for chronic pain since 2009. Many failed surgeries resulting in more nerve damage let alone the psychological challenge of constant surgical or medication failures and or intolerances expecting to become pain free after the next surgery promised to be a fix. Many in the medical profession shun you after their systemic failures. Contemplating life to continue living with chronic debilitating pain is so common. I’ve spent a fortune on the so called best physicians all to no avail. I live in fear when either I’ll become completely immune to all opioids, none that work as they once did or my Drs will stop prescribing using the reason I’m too good to turn into a drug dependant junkie of sorts

    2. Yes! Thank you. This article is so full of crap. Most addictions don’t come from legally prescribed opioid. It comes from street drugs and the bad stuff coming across our open borders!

  26. I have been suffering severe pain in neck a d over head as result of whiplash. I have had many treatments, and am extremele sensitive to medication. At moment I take about 9 Stilpane pills as well as about 4 mg ativan. Not helping. At night its worse and I also have burning mouth syndrome. Can you give advice please. Heila Janse van Rensburg

  27. God help chronic pain people, we need relief,Ian 70yr old experimental scoliosis patient for Dr. Herrington and need help so bad,no quality of life, Can’t find Doc who are even interested in helping me, please, please bring this to light asap. I just would like 1 day without pain. Thank you

  28. Pain control is good. Fact impaired smearing of safe and effective opiate Rx medicine is unnecessary and shouldn’t be in this article.

  29. I know of a woman, 61 , who has been struggling for 10+ years with chronic facial pain. She is at her wits end. Diagnosed with atypical facial pain she has tried all the meds. Seems like opiates help but…. Are you looking at human trials soon? Please advise, she would be interested.

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