A specific pathway of nerves and cells that link the gut to the brain may be responsible for chronic gut pain. Chronic gut pain is commonly associated with IBS, and mental health disorders including anxiety and depression.
Infants who are born preterm do not habituate to repeated pain the same way in which full-term babies or adults do. Researchers believe this is because preterm infants have not yet developed the mechanism that enables people to adapt to moderate pain, which is thought to develop during the third trimester of pregnancy.
A newly developed molecular diagnostic test is able to identify people who are most likely to benefit from hypnosis to help manage post-operative pain. This subset of highly hypnotizable people is also more likely to experience higher levels of post-operative pain.
Researchers investigate the degeneration process of musculoskeletal tissues that leads to chronic back and joint pain with the hope to translate their findings into new methods to repair tissue damage and ultimately relieve pain.
Natural resistance to capsaicin's effect in birds drove researchers to investigate a specific genetic variant that appears to be associated with pain resistance. They discovered the K710N human variant dialed down pain associated with capsaicin while enhancing the protective benefits of TRPV1. The findings could pave the way for the development of new treatments to manage pain.
SNRI antidepressants appear to be effective in the treatment of a range of pain conditions including neuropathic pain, fibromyalgia, and postoperative pain. Tricyclic antidepressants may not be effective in the treatment of pain.