COVID-19 infection leaves a gene expression signature in the dorsal root ganglia which persist after the virus has cleared. The signature matched other gene expression patterns seen in pain caused by other conditions.
A number of patients who contracted COVID-19 in the early months of the pandemic reported symptoms of neuropathy, including pain, tingling sensations, and numbness that lasted up to three months after recovery. The findings suggest COVID-19 may have lingering effects on peripheral nerves.
Researchers report some patients with long-COVID have lasting nerve damage that appears to be caused by infection-triggered immune dysfunction.
Brain circuitry responsible for motivation and pleasure is activated when a person experiences pain. The findings reveal a link as to why some people may overeat when they experience chronic pain.