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Pain

Pain Neuroscience news articles cover science research about pain receptors, nociceptors, nociception, sensory neurons, somatosensory cortex, chronic pain, acute pain, nocioceptors, musculoskeletal pain, therapies, phantom limb pain and other pain research.

Featured Genetics Neuroscience Pain

·February 2, 2023·6 min read

Possible New Way to Reduce Pain Inspired by Chickens

Natural resistance to capsaicin's effect in birds drove researchers to investigate a specific genetic variant that appears to be associated with pain resistance. They discovered the K710N human variant dialed down pain associated with capsaicin while enhancing the protective benefits of TRPV1. The findings could pave the way for the development of new treatments to manage pain.

This shows a drawing of a person holding the back in pain

Featured Neurology Neuroscience Open Neuroscience Articles Pain

·February 2, 2023·7 min read

Antidepressants Use for Chronic Pain on the Rise, but Are They Effective?

SNRI antidepressants appear to be effective in the treatment of a range of pain conditions including neuropathic pain, fibromyalgia, and postoperative pain. Tricyclic antidepressants may not be effective in the treatment of pain.

Featured Neurology Neuroscience Pain

·January 30, 2023·5 min read

Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

The Orai1 class of calcium channels regulates sex differences in the functioning of immune cells associated with neuroinflammation and neuropathic pain.

This shows a man holding his back in pain

Featured Neuroscience Pain Psychology

·January 30, 2023·5 min read

How Ketamine Acts as Antidepressant in Chronic Pain

Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.

This shows a child crying after falling over

Autism Featured Neuroscience Pain

·January 29, 2023·6 min read

People With Autism Experience Pain at a Higher Intensity

People with autism experience pain at a higher intensity than those not on the autism spectrum and are less adaptable to the sensation. This revelation contradicts the prevailing belief that those with ASD tend to be indifferent to pain.

Featured Neurology Neuroscience Pain

·January 26, 2023·5 min read

Supplementation With Amino Acid Serine Eases Diabetes Associated Neuropathy

Lower levels of serine and glycine were associated with a higher risk of neuropathic pain in mouse models of diabetes. Supplementing the diets of the mice with serine reduced symptoms of neuropathy. Researchers say the findings provide a new way in which to identify people at risk of diabetic neuropathy and a potential treatment option.

Featured Neuroscience Pain

·January 13, 2023·6 min read

Scientists Take Another Step Toward Building a Better, Safer Opioid

Using cryoEM technology, researchers have decoded the detailed structures of an entire family of opioid receptors bound to their naturally occurring peptides. This new structural framework should help in the development of safer, more effective medications to treat chronic pain.

Featured Neurology Neuroscience Pain

·January 10, 2023·5 min read

Study Reveals Mechanism Involved in Neuropathic Pain and Could Help Develop Specific Treatment

Study reveals the role played by neuropathic pain in dendritic cells in the meninges via an increase in the metabolic kynurenine pathway. When the kynurenine pathway initiated by IDO1 was blocked, neuropathic pain was nullified.

This shows a person holding a dropper and a bottle

Featured Neurology Neuroscience Pain

·January 6, 2023·4 min read

Nearly 1/3 of People With Chronic Pain Turn to Cannabis

Study reveals almost one-third of chronic pain patients use cannabis to help manage their symptoms.

Featured Neurology Neuroscience Pain

·December 27, 2022·3 min read

Researchers Study Pain-Relieving Neural Mechanisms by Activation of the Motor Cortex

Study reveals a new brain circuit for neurostimulation in pain therapy.

Featured Neurology Neuroscience Open Neuroscience Articles Pain

·December 12, 2022·5 min read

The More TV You Watch, the More Bodily Pain You Have Over Time

Increased daily television viewing is significantly associated with an increase in bodily and chronic pain severity over time, especially for those with Type 2 Diabetes.