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Genetics

Genetics articles related to neuroscience research will be listed here.

·November 15, 2024·3 min read

Mapping Protein Changes Across Aging

Researchers have developed the Mouse Aging Proteomic Atlas, a comprehensive database detailing protein changes in major tissues as mice age. By analyzing proteomes and transcriptomes across tissues like the brain, heart, and skin, they uncovered proteins linked to aging, particularly in the extracellular matrix.

Featured Genetics Neurology Neuroscience

·November 13, 2024·7 min read

Huntington’s Gene Enhances Early Brain Growth and Intelligence

A study reveals that the genetic mutation causing Huntington’s disease (HD) enhances brain development and intelligence in early life, but leads to degeneration in adulthood. Children with the HD gene exhibit larger brains and higher IQs than those without the mutation.

Featured Genetics Neurology Neuroscience

·November 13, 2024·6 min read

Parkinson’s Progression Linked to New Protein Pathway

Researchers have identified a protein, TMEM16F, that appears to aid the spread of Parkinson’s pathology in the brain. They found that a mutation in this protein promotes the secretion of a harmful form of α-synuclein, which moves through nerve cells, forming toxic Lewy bodies.

Featured Genetics Neuroscience

·November 13, 2024·3 min read

Could Targeting Genetics Reduce Our Cravings for Sugary Foods?

A new study has revealed how genetic variations in the SI gene, which affects sucrose digestion, influence dietary preferences and intake of sugary foods. Researchers found that individuals with limited sucrose-digesting ability, due to specific genetic variations, showed reduced sugar cravings and consumption. This discovery opens up the potential to develop targeted treatments to reduce sugar intake on a population level, potentially reducing the incidence of obesity and type 2 diabetes.

Featured Genetics Neurology Neuroscience

·November 11, 2024·4 min read

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key feature of Alzheimer’s disease and related dementias. By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway.

Featured Genetics Neuroscience

·November 9, 2024·4 min read

Cells Beyond the Brain Show Surprising Memory Abilities

New research reveals that cells outside the brain can store and process memories, challenging the view that memory is limited to neurons. Scientists found that non-brain cells, when exposed to spaced chemical signals, activated a "memory gene" similarly to neurons.

This shows a man's face and broken bottles.

Featured Genetics Neurology Neuroscience

·November 5, 2024·5 min read

Gene Study Links Alcohol Addiction to Accelerated Alzheimer’s Progression

Researchers discovered alcohol use disorder (AUD) and Alzheimer's disease (AD) exhibit similar patterns of gene dysregulation, hinting that alcohol consumption may hasten Alzheimer’s progression. By analyzing gene expression across individual brain cells, the team found shared disruptions in inflammation, cell signaling, and blood vessel functions in both disorders.

Featured Genetics Neurology Neuroscience

·November 3, 2024·3 min read

RNA Structures Linked to Parkinson’s Protein Aggregates

Researchers have identified unique RNA structures called G-quadruplexes (G4s) that promote harmful α-synuclein protein aggregation linked to neurodegenerative diseases like Parkinson’s. Elevated calcium levels trigger these G4s, acting as "scaffolds" for α-synuclein clumping. Administering 5-aminolevulinic acid (5-ALA) to model mice prevented aggregation and reduced motor symptoms. This breakthrough suggests that G4-targeted therapies could offer early intervention for neurodegenerative diseases.

Featured Genetics Neuroscience

·November 1, 2024·4 min read

Honeybee Behavior Genetically Programmed

The doublesex (dsx) gene in honeybees determines specific worker bee behaviors like foraging and brood care. By modifying this gene, they found dsx directly affects neural pathways, encoding behaviors essential to colony survival.

Featured Genetics Neuroscience

·November 1, 2024·5 min read

Study Identifies Neural Crest Stem Cells as Reprogramming Drivers

Neural crest stem cells, a rare type found in skin and other tissues, are uniquely capable of reprogramming into different cell types, challenging the prevailing belief that any mature cell can be reprogrammed. The study reveals that cellular reprogramming is likely limited to these specialized stem cells rather than all mature cells. Neural crest stem cells are present in skin, bone, and connective tissue, with a natural predisposition for transformation due to their origin in embryonic development.

Featured Genetics Neuroscience

·October 31, 2024·6 min read

How Brain Proteins Shape Neural Connections

A new study links hundreds of brain proteins to differences in how brain regions communicate, revealing how microscale molecules can influence macroscale brain connectivity. Researchers studied brain samples and scans from elderly participants to map biochemical mechanisms affecting structural and functional connectivity in the brain. By integrating protein and RNA data with neuroimaging, they identified key proteins associated with communication between brain areas.

Featured Genetics Neurology Neuroscience

·October 28, 2024·4 min read

Key Biochemical Trigger of Huntington’s Disease Progression Identified

Researchers have identified a crucial biochemical mechanism that could allow Huntington’s disease to be studied before symptoms appear, offering hope for early intervention. The team found that disrupted dopamine regulation in specific neurons, related to TrkB neurotrophin receptor signaling, may trigger Huntington’s onset. By targeting an enzyme called GSTO2, researchers prevented motor symptoms in a mouse model, suggesting this protein's role in the disease's progression.

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Genetics

Mapping Protein Changes Across Aging

Huntington’s Gene Enhances Early Brain Growth and Intelligence

Parkinson’s Progression Linked to New Protein Pathway

Could Targeting Genetics Reduce Our Cravings for Sugary Foods?

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

Cells Beyond the Brain Show Surprising Memory Abilities

Gene Study Links Alcohol Addiction to Accelerated Alzheimer’s Progression

RNA Structures Linked to Parkinson’s Protein Aggregates

Honeybee Behavior Genetically Programmed

Study Identifies Neural Crest Stem Cells as Reprogramming Drivers

How Brain Proteins Shape Neural Connections

Key Biochemical Trigger of Huntington’s Disease Progression Identified

Looksmaxxing Trend Poses Health Risks for Young Men

How “Pink Noise” in Conversation Makes Chats Enjoyable

Can Obesity Drugs Protect the Brain?

SuperAger AI Connectome Predicts Alzheimer’s Years Early

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