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Genetics

Genetics articles related to neuroscience research will be listed here.

·January 8, 2025·5 min read

Single Gene Links Autism, Epilepsy via Brain Circuit Development

The gene neuropilin2 regulates inhibitory neuron migration and excitatory neuron connections, essential for balanced brain activity. A study revealed that deleting neuropilin2 disrupts inhibitory circuits, leading to autism-like behaviors and a higher seizure risk.

This shows computer generated versions of human cells.

Brain Cancer Featured Genetics Neuroscience

·January 8, 2025·7 min read

AI Reveals Gene Activity in Human Cells

Researchers have developed an AI model that accurately predicts gene activity in any human cell, providing insights into cellular functions and disease mechanisms. Trained on data from over 1.3 million cells, the model can predict gene expression in unseen cell types with high accuracy. It has already uncovered mechanisms driving a pediatric leukemia and may help explore the genome's "dark matter," where most cancer mutations occur.

This shows an AI representation of protein clumps.

Featured Genetics Neurology Neuroscience

·January 8, 2025·5 min read

Visualizing Huntington’s Protein Aggregates

Scientists have visualized the detailed structure of protein clumps linked to Huntington's disease, offering critical insights into the condition’s molecular basis. Using advanced simulations and experimental techniques, the team identified how these clumps differ from those in Alzheimer’s and Parkinson’s diseases.

Featured Genetics Neurology Neuroscience

·January 7, 2025·8 min read

AI Predicts Autoimmune Disease Progression with New Genetic Tool

Researchers have developed a Genetic Progression Score (GPS) using artificial intelligence to predict the progression of autoimmune diseases from preclinical symptoms to full disease. The GPS model integrates genetic data and electronic health records to provide personalized risk scores, improving prediction accuracy by 25% to 1,000% over existing models.

This shows a rendition of proteins clumping.

Featured Genetics Neurology Neuroscience

·January 6, 2025·3 min read

Lipid Anchors Hold Key to Preventing Protein Aggregation in Prion Diseases

A lipid anchor on nerve cell membranes stabilizes prion proteins (PrPC) and prevents their pathological aggregation into forms linked to prion diseases. Researchers developed new in vitro and cell models to study how membrane anchoring inhibits these harmful transformations.

Featured Genetics Neuroscience

·January 6, 2025·7 min read

The Genetic Impact of Forever Chemicals on Brain Function

Researchers have found that per- and polyfluorinated alkyl substances (PFAS) alter the expression of specific genes in brain-like cells, potentially contributing to neurotoxicity. Among six tested compounds, perfluorooctanoic acid (PFOA) caused the most significant changes, downregulating genes crucial for neuron survival and upregulating those linked to cell death.

Featured Genetics Neuroscience

·January 4, 2025·6 min read

New Insight into Genetic Disease Variability

New research reveals that certain cells inactivate one parent’s copy of a gene, leading to a bias in gene activity that may explain why some individuals with disease-causing mutations remain symptom-free. This selective gene inactivation, known as monoallelic expression, affects about 1 in 20 genes and varies between cell types.

Featured Genetics Neuroscience

·January 2, 2025·7 min read

Gene Expression Drives Evolution of Human Brain Complexity

While humans share over 95% of their genome with chimpanzees, our brains are far more complex due to differences in gene expression. Research shows that human brain cells, particularly glial cells, exhibit higher levels of upregulated genes, enhancing neural plasticity and development.

Featured Genetics Neuroscience

·December 31, 2024·3 min read

How Early Experiences Shape Genes, Brain Health, and Resilience

New research in epigenetics reveals how early-life experiences influence gene expression and brain development. By bridging the gap between nature and nurture, this work shows that environmental factors leave lasting biological imprints, shaping long-term health and resilience.

Autism Featured Genetics Neuroscience

·December 27, 2024·5 min read

Lithium Restores Brain Function and Behavior in Autism

Lithium, a drug widely used for bipolar disorder, may also treat autism spectrum disorder (ASD), according to new research. The study found that lithium restored brain function and reduced behavioral symptoms in mice with Dyrk1a gene mutations, a known ASD risk factor.

Featured Genetics Neuroscience

·December 21, 2024·8 min read

Rare Brain Cells Offer Clues to Aging and Rejuvenation

A study reveals how brain cell interactions influence aging, showing that rare cell types either accelerate or slow brain aging. Neural stem cells provide a rejuvenating effect on neighboring cells, while T cells drive aging through inflammation.

Featured Genetics Neuroscience

·December 19, 2024·7 min read

New Genetic Link to Autism Identified on X Chromosome

Researchers identified variants in the DDX53 gene, located on the X chromosome, as contributors to autism spectrum disorder (ASD). These genetic variants, found predominantly in males, provide critical insights into the biological mechanisms behind autism’s male predominance. The study also uncovered another potential gene, PTCHD1-AS, near DDX53, linked to autism, emphasizing the complexity of ASD’s genetic architecture.

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Genetics

Single Gene Links Autism, Epilepsy via Brain Circuit Development

AI Reveals Gene Activity in Human Cells

Visualizing Huntington’s Protein Aggregates

AI Predicts Autoimmune Disease Progression with New Genetic Tool

Lipid Anchors Hold Key to Preventing Protein Aggregation in Prion Diseases

The Genetic Impact of Forever Chemicals on Brain Function

New Insight into Genetic Disease Variability

Gene Expression Drives Evolution of Human Brain Complexity

How Early Experiences Shape Genes, Brain Health, and Resilience

Lithium Restores Brain Function and Behavior in Autism

Rare Brain Cells Offer Clues to Aging and Rejuvenation

New Genetic Link to Autism Identified on X Chromosome

100,000 Small Factors Rival DNA in Disease Risk

The Brain Stacks Sound Information to Navigate the Dark

Edge of Chaos: Why Pigeons Refuse to Become “Machines”

Brain’s Default Setting for Ambiguity Matters for Mental Health

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