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tRNA

·September 27, 2024·3 min read

Enzyme Key to Brain Function and Synapse Health Discovered

A new study reveals that the absence of the TRMT10A enzyme disrupts tRNA levels, leading to impaired protein synthesis and brain function. Researchers found that mice lacking the Trmt10a gene had decreased levels of key tRNAs, which affected neuronal synapses and cognitive abilities.

Featured Genetics Neurology Neuroscience

·May 13, 2024·4 min read

tRNA Fragments Linked to Alzheimer’s

A new study identifies a crucial factor in brain aging and Alzheimer's disease—the accumulation of Glu-5’tsRNA-CTC in neuron mitochondria. This small RNA fragment disrupts mitochondrial protein synthesis and cristae structure, accelerating cognitive decline and Alzheimer’s pathology.

Featured Genetics Neurology Neuroscience

·November 29, 2021·5 min read

Why Some People Experience Early Onset Neurodegenerative Diseases

A new study sheds light on the genetic causes of a range of neurodegenerative disorders, including ALS, Parkinson's disease, and Huntington's disease, and determines factors that impact the age of onset as well as disease severity.

Featured Genetics Neurology Neuroscience

·September 30, 2019·4 min read

‘Relaxed’ enzymes may be at the root of Charcot-Marie-Tooth disease

The severity of Charcot-Marie-Tooth disease is linked to the degree to which the aminoacyl-tRNA synthetases enzyme is relaxed or extended.

Featured Genetics Neurology

·May 16, 2018·3 min read

Gene that Helps Prevent Brain Disease Identified

Researchers report the ANKRD16 can prevent protein aggregates associated with neurodegenerative diseases.

Featured Genetics Neuroscience

·August 10, 2017·4 min read

Circular RNA Linked to Brain Function

A new study reveals the role circular RNA plays in brain function, including synaptic transmission and sensorimotor gating.

Featured Genetics

·October 12, 2015·4 min read

Mapping Genes That Increase Lifespan

Researchers have identified over 230 genes which, when deleted, increase the replicative life span of yeast cells. 189 of these genes have been linked to aging and the researchers believe the results could provide new genomic targets that could be used to improve human health.