TH17

Latest

TH17

·March 14, 2023·5 min read

Molecular Component of Caffeine May Play a Role in Gut Health

Xanthine, a purine metabolite found in caffeinated products such as coffee and tea, and in chocolate, appears to play a role in TH17 cell differentiation in the gut. The findings may lead to a better understanding of gut health and shed new light on the development of inflammatory disorders such as IBD.

Featured Neuroscience

·August 30, 2022·5 min read

Sugar Disrupts Microbiome, Eliminates Protection Against Obesity and Diabetes

Western diets high in sugars reduce the number of Th17 inflammatory cells in the guts of mice, setting off a chain of events that lead to metabolic diseases, prediabetes, and obesity.

Featured Neurology Neuroscience

·March 18, 2020·5 min read

Using “organs-on-a-chip” to model complicated diseases

Organ-on-a-chip models reveal how different tissue contribute to inflammatory diseases such as ulcerative colitis.

Featured Genetics Neurology Neuroscience

·February 4, 2020·5 min read

Dietary interventions may slow onset of inflammatory and autoimmune disorders

Reducing dietary levels of methionine can slow the onset and progression of inflammatory and autoimmune diseases, such as multiple sclerosis, in those with high-risk factors.

Featured Genetics Neurology Neuroscience

·January 3, 2020·6 min read

Fat-dissolving bile acids may help regulate gut immunity and inflammation

Two studies reveal the role bile acids play in immunity and inflammation.

Featured Genetics Neurology Neuroscience

·October 4, 2019·4 min read

Targeting certain rogue T cells prevents and reverses multiple sclerosis: Mouse study

TH17 cells produced increased amounts of SerpinB1, a protein implicated in multiple sclerosis symptoms. SerpinB1 cells were identified with antibodies targeting the CXCR6 surface protein. Using monoclonal antibodies to target CXCR6, the cells disappeared significantly, and the mice primed to develop MS did not develop the disease.

Featured Genetics Neurology

·January 29, 2018·4 min read

Men Hold Secret to Protect Women From Multiple Sclerosis

A new PNAS study reveals why men are less likely to develop multiple sclerosis than women. According to researchers, a 'guardian molecule' that is triggered by testosterone appears to have a protective effect in men. When female mice were treated with the molecule, their symptoms of the disease were eliminated.

Featured Neurology

·January 16, 2018·4 min read

High Salt Diet Produces Dementia: Mouse Study

Researchers reveal high salt intake reduces resting cerebral blood flow and can contribute to dementia in mice.

a graphical abstract from the research paper

Featured Neurology Open Neuroscience Articles

·November 22, 2017·5 min read

How Rogue Immune Cells Cross the Blood-Brain Barrier to Cause Multiple Sclerosis

Researchers have discovered how TH1 and TH17 immune cells obtain access to neurons in multiple sclerosis.

Autism Featured Psychology

·September 13, 2017·8 min read

Blocking Gut Bacteria Strains May Reduce Autism Risk Linked to Maternal Infection

MIT researchers report mothers who contract severe infections during pregnancy face higher autism risks in their children. However, ASD risks could be reduced by blocking the function of certain strains of bacteria found in the mother's gut.

The image is a diagram showing the effects MS has on the human body.

Featured Genetics

·April 27, 2015·4 min read

Researchers Discover a Way to Prevent the Development of Multiple Sclerosis in Mice

A new study reports researchers have been successful in protecting against the onset of multiple sclerosis in an animal model of the disease.

The image is a cervical spine MRI with enhancement showing multiple sclerosis.

Featured Genetics

·June 24, 2013·3 min read

Absence of Gene Leads to Earlier, More Severe Case of Multiple Sclerosis

A new study identifies a possible genetic mechanism that causes a quicker progression of multiple sclerosis. The absence of Tob1 in CD4+ T cells is key to early onset of a more aggressive form of MS.

1 2