Using “organs-on-a-chip” to model complicated diseases
Organ-on-a-chip models reveal how different tissue contribute to inflammatory diseases such as ulcerative colitis.... Read More...
TH17
Dietary interventions may slow onset of inflammatory and autoimmune disorders
Reducing dietary levels of methionine can slow the onset and progression of inflammatory and autoimmune diseases, such as multiple sclerosis, in those with high-risk factors. ... Read More...
Fat-dissolving bile acids may help regulate gut immunity and inflammation
Two studies reveal the role bile acids play in immunity and inflammation. ... Read More...
Targeting certain rogue T cells prevents and reverses multiple sclerosis: Mouse study
TH17 cells produced increased amounts of SerpinB1, a protein implicated in multiple sclerosis symptoms. SerpinB1 cells were identified with antibodies targeting the CXCR6 surface protein. Using monoclonal antibodies to target CXCR6, the cells disappeared significantly, and the mice primed to develop MS did not develop the disease.... Read More...
Men Hold Secret to Protect Women From Multiple Sclerosis
A new PNAS study reveals why men are less likely to develop multiple sclerosis than women. According to researchers, a 'guardian molecule' that is triggered by testosterone appears to have a protective effect in men. When female mice were treated with the molecule, their symptoms of the disease were eliminated.... Read More...
High Salt Diet Produces Dementia: Mouse Study
Researchers reveal high salt intake reduces resting cerebral blood flow and can contribute to dementia in mice.... Read More...
How Rogue Immune Cells Cross the Blood-Brain Barrier to Cause Multiple Sclerosis
Researchers have discovered how TH1 and TH17 immune cells obtain access to neurons in multiple sclerosis. ... Read More...
Blocking Gut Bacteria Strains May Reduce Autism Risk Linked to Maternal Infection
MIT researchers report mothers who contract severe infections during pregnancy face higher autism risks in their children. However, ASD risks could be reduced by blocking the function of certain strains of bacteria found in the mother's gut.... Read More...
Researchers Discover a Way to Prevent the Development of Multiple Sclerosis in Mice
A new study reports researchers have been successful in protecting against the onset of multiple sclerosis in an animal model of the disease.... Read More...
Absence of Gene Leads to Earlier, More Severe Case of Multiple Sclerosis
A new study identifies a possible genetic mechanism that causes a quicker progression of multiple sclerosis. The absence of Tob1 in CD4+ T cells is key to early onset of a more aggressive form of MS.... Read More...
Gut Bacteria Can Affect Onset of Multiple Sclerosis
Gut bacteria, previously considered benign, has the ability to alter the immune system of mice enough to affect the rate of Multiple Sclerosis occurance. ... Read More...