Scientists have developed human stem cell models containing the notochord, a critical tissue that guides spine and nervous system formation during embryonic development. Using precise chemical signals inspired by natural processes in chicken, mouse, and monkey embryos, the researchers successfully coaxed human stem cells to form a notochord and a miniature trunk-like structure. This innovation mirrors key features of human development and could advance the study of spine-related birth defects and conditions like intervertebral disc degeneration.
