Monitoring Spinal Cord Activity During Surgery in Real-Time

Summary: fUSI technology is offering new hope to chronic back pain sufferers by providing high-resolution images of the human spinal cord during surgery. This innovative tool not only visualizes the spinal cord but also tracks the cord’s real-time response to treatments, marking a significant leap over traditional imaging methods like fMRI, with its superior sensitivity to neuroactivation and reduced susceptibility to motion artifacts.

Tested on six patients undergoing electrical stimulation for chronic pain, fUSI technology demonstrated an unprecedented ability to monitor treatment efficacy by observing blood flow changes in the spinal cord. This advancement promises to enhance the success rate of spinal surgeries and potentially improve treatments for other conditions, like bladder control issues, by enabling precise, individualized care.

Key Facts:

  1. Advanced Imaging Capabilities: fUSI technology surpasses traditional imaging by offering ten times the sensitivity in detecting spinal cord activity and is not hindered by motion artifacts.
  2. Real-Time Treatment Monitoring: For the first time, surgeons can observe the immediate effects of treatments on spinal cord blood flow, offering a direct indicator of success during procedures.
  3. Promising Clinical Results: Initial testing on patients with chronic back pain showed fUSI’s potential to significantly improve the success rates of spinal surgeries by providing detailed insights into blood flow changes.

Source: UCR

With technology developed at UC Riverside, scientists can, for the first time, make high resolution images of the human spinal cord during surgery. The advancement could help bring real relief to millions suffering chronic back pain.

The technology, known as fUSI or functional ultrasound imaging, not only enables clinicians to see the spinal cord, but also enables them to map the cord’s response to various treatments in real time.

A paper published today in the journal Neuron details how fUSI worked for six people undergoing electrical stimulation for chronic back pain treatment.

This shows a surgeon.
For this surgery, clinicians stimulated the spinal cord with electrodes, in the hopes that the voltage would alleviate the patient’s discomfort and improve their quality of life. Credit: Neuroscience News

“The fUSI scanner is freely mobile across various settings and eliminates the requirement for the extensive infrastructure associated with classical neuroimaging techniques, such as functional magnetic resonance imaging (fMRI),” said Vasileios Christopoulos, assistant professor of bioengineering at UCR who helped develop the technology.

“Additionally, it offers ten times the sensitivity for detecting neuroactivation compared to fMRI.”

Until now, it has been difficult to evaluate whether a back pain treatment is working since patients are under anesthesia and asleep. Thus, the patients cannot provide verbal feedback on their pain levels during treatment.

“With ultrasound, we can monitor blood flow changes in the spinal cord induced by the electrical stimulation. This can be an indication that the treatment is working,” Christopoulos said.

The spinal cord is an “unfriendly area” for traditional imaging techniques due to significant motion artifacts, such as heart pulsation and breathing.

“These movements introduce unwanted noise into the signal, making the spinal cord an unfavorable target for traditional neuroimaging techniques,” Christopoulos said. 

By contrast, fUSI is less sensitive to motion artifacts. It emits sound waves into the area of interest, and red blood cells in that area echo the sound, producing a clear image.

“It’s like submarine sonar, which uses sound to navigate and detect objects underwater,” Christopoulos said. “Based on the strength and speed of the echo, they can learn a lot about the objects nearby.”

Christopoulos partnered with the USC Neurorestoration Center at Keck Hospital to test the technology on six patients with chronic low back pain. These patients were already scheduled for the last-ditch pain surgery, as no other treatments, including drugs, had helped to ease their suffering. 

For this surgery, clinicians stimulated the spinal cord with electrodes, in the hopes that the voltage would alleviate the patient’s discomfort and improve their quality of life. 

“If you bump your hand, instinctively, you rub it. Rubbing increases blood flow, stimulates sensory nerves, and sends a signal to your brain that masks the pain,” Christopoulos said. “We believe spinal cord stimulation may work the same way, but we needed a way to view the activation of the spinal cord induced by the stimulation.”  

The Neuron paper details how fUSI can detect blood flow changes at unprecedented levels of less than 1 millimeter per second. For comparison, fMRI is only able to detect changes of 2 centimeters per second. 

“We have big arteries and smaller branches, the capillaries. They are extremely thin, penetrating your brain and spinal cord, and bringing oxygen places so they can survive,” Christopoulos said. “With fUSI, we can measure these tiny but critical changes in blood flow.”

Generally, this type of surgery has a 50% success rate. With improved monitoring of the blood flow changes, Christopoulos hopes this rate will increase dramatically. “We needed to know how fast the blood is flowing, how strong, and how long it takes for blood flow to get back to baseline after spinal stimulation. Now, we will have these answers,” Christopoulos said. 

Moving forward, the researchers are also hoping to show that fUSI can help optimize treatments for patients who have lost bladder control due to spinal cord injury or age.

“We may be able to modulate the spinal cord neurons to improve bladder control,” Christopoulos said. 

“With less risk of damage than older methods, fUSI will enable more effective pain treatments that are optimized for individual patients,” Christopoulos said. “It is a very exciting development.”

About this neurotech and neurology research news

Author: Jules Bernstein
Source: UCR
Contact: Jules Bernstein – UCR
Image: The image is credited to Neuroscience News

Original Research: The findings will appear in Neuron

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