Long-term circadian rhythm disruptions induce Alzheimer's disease-like pathology in rats, which can be reversed by administering fluoxetine. Additionally, elevated levels of amyloid beta and circadian rhythm disruptions can trigger each other, leading to the cascade of neurological symptoms of dementia.
The genes GRB10 and ABTB1 are influential in nutrient-sensing pathways and memory. Researchers say these genes may be the molecular links between diet, neural stem cell aging, and cognitive ability.
Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.
Researchers report activating the SIRT1 gene in male mice helped to reverse symptoms of depression, such as social isolation and loss of interest. The study suggests drugs that activate SIRT1 may be an effective therapy for some with major depression.
Researchers report becoming overweight at an early age can trigger the early onset of puberty in females.
Resveratrol analogues appears to switch splicing factors back on, causing cells to look younger, start rejuvenating and behaving like young cells within hours of exposure, a new study reports.
ST266 produces an anti-inflammatory effect and can help preserve cells in the optic nerve, a new study reports.
Researchers report dysregulated expression of a gene complex could explain why PMDD is a disorder of cellular response to progesterone and estrogen.
A new study reports Sirt1 can help glial cells to regenerate from progenitor cells in preterm babies with hypoxia related injuries.
Researchers report resveratrol, a naturally occurring compound found in red wine and dark chocolate, appears to improve the integrity of the blood brain barrier in patients with Alzheimer's disease.
A new study reports reveratrol could be a therapeutic candidate for the management and treatment of Alzheimer's disease.
According to a new study, AgRP neurons not only control huger, they also regulate bone mass.