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SIRT1

Featured Genetics Neurology Neuroscience

·August 19, 2021·5 min read

Disturbed Circadian Rhythm May Be Associated With Alzheimer’s Disease

Long-term circadian rhythm disruptions induce Alzheimer's disease-like pathology in rats, which can be reversed by administering fluoxetine. Additionally, elevated levels of amyloid beta and circadian rhythm disruptions can trigger each other, leading to the cascade of neurological symptoms of dementia.

Featured Genetics Neuroscience Open Neuroscience Articles

·April 2, 2020·4 min read

Lifestyle changes could delay memory problems in old age, depending on our genes

The genes GRB10 and ABTB1 are influential in nutrient-sensing pathways and memory. Researchers say these genes may be the molecular links between diet, neural stem cell aging, and cognitive ability.

Featured Genetics Neuroscience Open Neuroscience Articles

·July 25, 2019·4 min read

To become, or not to become… a neuron

Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·February 18, 2019·5 min read

Depression Reversed by Activating Gene That Helps Excite Neurons: Male Mouse Study

Researchers report activating the SIRT1 gene in male mice helped to reverse symptoms of depression, such as social isolation and loss of interest. The study suggests drugs that activate SIRT1 may be an effective therapy for some with major depression.

Featured Genetics Neuroscience Open Neuroscience Articles

·October 11, 2018·4 min read

A Molecular Link Between Body Weight and Early Puberty Identified

Researchers report becoming overweight at an early age can trigger the early onset of puberty in females.

Featured Genetics Open Neuroscience Articles

·November 7, 2017·5 min read

Old Human Cells Rejuvenated in Breakthrough Discovery on Aging

Resveratrol analogues appears to switch splicing factors back on, causing cells to look younger, start rejuvenating and behaving like young cells within hours of exposure, a new study reports.

Featured Neurology Neuroscience Open Neuroscience Articles Visual Neuroscience

·February 9, 2017·5 min read

Anti-Cell Death Agent A Potential Treatment For Vision Loss in MS

ST266 produces an anti-inflammatory effect and can help preserve cells in the optic nerve, a new study reports.

Image shows a diagram of the gene network.

Featured Genetics Psychology

·January 3, 2017·5 min read

Premenstrual Mood Disorder Linked to Sex Hormone Sensitive Gene Complex

Researchers report dysregulated expression of a gene complex could explain why PMDD is a disorder of cellular response to progesterone and estrogen.

Featured Genetics Neurology

·December 19, 2016·5 min read

Sirt1 Regulates Proliferation and Regeneration of Glial Progenitor Cells After Injury

A new study reports Sirt1 can help glial cells to regenerate from progenitor cells in preterm babies with hypoxia related injuries.

Image shows a bar of chocolate and a bottle of wine.

Featured Neurology

·July 27, 2016·4 min read

Resveratrol May Restore Integrity of Blood-Brain Barrier in Alzheimer’s

Researchers report resveratrol, a naturally occurring compound found in red wine and dark chocolate, appears to improve the integrity of the blood brain barrier in patients with Alzheimer's disease.