SHANK3

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SHANK3

·May 7, 2019·2 min read

Autism gene linked to brain and behavior deficits in mice

A deficiency of the SHANK3 gene, a gene associated with ASD, results in structural and functional deficits in the prefrontal cortex. The functional and structural alterations in the PFC were linked to an impairment in social interaction in male mice.

This showa a child looking at a DNA strand

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·April 29, 2019·5 min read

Study links gene to sleep problems in autism

Deficiencies in the SHANK3 gene have been linked to sleep disruptions in both mouse models and people with ASD. Researchers found patients with Phelan-McDermid syndrome, a genetic disorder associated with autism, report trouble falling, and staying asleep. In mouse models, animals lacking the SHANK3 gene had a reduction in deep sleep quality and spent more time awake when other mice were sleeping.

Autism Featured Neuroscience Open Neuroscience Articles

·November 9, 2018·4 min read

Autism Associated with Zinc Deficiency in Early Development

A new study reveals a mechanistic link between zinc levels in fetal development, genes and abnormal neural connections associated with autism.

Autism Featured Genetics

·February 16, 2018·5 min read

Lab Grown Human Cerebellar Cells Yield Clues to Autism

Researchers have derived purkinje cells from patients with TSC, a genetic syndrome that includes some ASD-like symptoms. The cells, researchers say, have several characteristics that could help explain how ASD develops at the molecular level.

Autism Featured Genetics

·August 18, 2017·3 min read

CRISPR Advances Autism Research

Using CRISPR gene editing technology, researchers target the Shank3 gene in monkey embryos. Research backs previous findings of the importance of the Shank3 gene for brain development and its role in autism.

Autism Featured Neurology Pain

·December 1, 2016·5 min read

Autism Linked Protein Crucial For Feeling Pain

TRPV1 and SHANK3 could play a role in pain insensitivity in people with autism, a new study reports.

Autism Featured Genetics

·September 1, 2016·5 min read

Zinc May Help Reverse Brain Changes in Autism

According to researchers, cellular changes in the brain caused by genetic mutations associated with Autism can be reversed with the help of zinc.

Autism Featured Genetics

·May 25, 2016·4 min read

Illuminating the Role of Autism Linked Shank Gene

A new study reports a gene mutation linked to autism also plays a critical role when it comes to the formation and maturation of synapses.

Autism Featured Genetics Neuroscience Videos Open Neuroscience Articles Psychology

·May 10, 2016·5 min read

Mouse Model of Autism Offers Insights For Human Patients

Researchers have developed a new mouse model of a genetically linked type of autism. The new model helps reveal more about the role of genes and brain changes associated with the disorder.

Autism Featured Genetics

·February 18, 2016·5 min read

Researchers Reverse Autism Symptoms

Researchers demonstrate they can reverse some autism symptoms in mice by turning the Shank3 gene on later in life, allowing the brain to correctly rewire itself.

Image shows the word Shank3 and models of molecules.

Autism Featured Genetics Psychology

·December 10, 2015·6 min read

One Gene Plays Role in Autism and Schizophrenia

A new study reports on the role Shank3 plays in both schizophrenia and autism.

The image shows a child holding a sign with the word autism written on it.

Autism Featured Open Neuroscience Articles

·June 11, 2013·3 min read

Researchers Provide the First Comprehensive and Prospective Characterization of a Genetic Subtype of Autism

Researchers provide new evidence for the severity of motor, intellectual and speech impairments in Phelan-McDermid Syndrome, a sub-type of autism characterized by a mutation of the SHANK3 gene.

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