HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.
A clinical trial of an Alzheimer’s disease treatment developed found that the nutrient cocktail can improve memory in patients with early Alzheimer’s. The mixture appears to increase the number of dendritic spines and therefore some synapses.
Preliminary results in mice show that Fgf injections near a spinal injury increase both the number of glia cells at the site and the elongated morphology. Their evidence suggests that Fgfs may work to create an environment more supportive of regeneration in mammals as well and could be a valuable therapeutic target.
Honeybees can reverse brain aging and learning deficits when they take on nest responsibilities usually done by younger bees. Findings suggest social interventions may be used to slow or treat age-related dementia.
‘HD in a dish’ will facilitate search for elusive treatment. An international consortium of Huntington’s disease experts, including several from...
Long-term aim is to develop new treatments to block the spread of damaged proteins in the brain. Van Andel Institute...
RTC 13 effectively counteracts ‘nonsense’ mutation that causes disorder. Scientists at UCLA have identified a new compound that could treat...
Researchers from the Huck Institutes’ Center for Cellular Dynamics, led by Center director Melissa Rolls, have found that a neuroprotective...
Scientists have developed a small-molecule-inhibiting drug that in early laboratory cell tests stopped breast cancer cells from spreading and also...
Single treatment produces long-term improvement in animal models. With a single drug treatment, researchers at the Ludwig Institute for Cancer...
A protein required to regrow injured peripheral nerves has been identified by researchers at Washington University School of Medicine in...
Gene involved in dementia affects the insulin pathway, reports biology professor Chris Li and colleagues. In recent years it became...