Researchers identified a group of closely related genes that capture molecular links between Alzheimer's and LATE, a common brain disorder that mimics Alzheimer's symptoms.
Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime.
The largest genetic map of mental health disorders to date reveals there are three groups of highly genetically related disorders among eight psychiatric disorders. A gene related to nervous system development is a risk factor for all eight disorders studied. The RBFOX1 gene is implicated in seven of the eight disorders. ADHD and depression share 44% of genetic risk factors common in the general population. 109 pleiotropic loci affect more than one disorder. These pleiotropic loci are within genes that show heightened expression in the brain through the lifespan, beginning during the second trimester of pregnancy.
Researchers have identified 40 new genes they believe are related to aggressive behavior in both humans and mice. The findings deepen understanding of the genetic basis of aggressiveness.
A new paper explores different findings about the development of Alzheimer's and considers how personalized treatments may help combat this complex disease.
A new study reports on how a genetic mutation could lead to the development of Autism. The findings also point to new drug targets for the disorder.