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          prion disease

          This shows a rendition of proteins clumping.
          FeaturedGeneticsNeurologyNeuroscience
          ·January 6, 2025·3 min read

          Lipid Anchors Hold Key to Preventing Protein Aggregation in Prion Diseases

          A lipid anchor on nerve cell membranes stabilizes prion proteins (PrPC) and prevents their pathological aggregation into forms linked to prion diseases. Researchers developed new in vitro and cell models to study how membrane anchoring inhibits these harmful transformations.
          Read More
          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·September 30, 2024·4 min read

          Prion Disease Mutations Impact Synapses Before Symptoms Appear

          New research reveals that prion disease mutations can alter the structure of neuron synapses long before symptoms emerge. Scientists studied neurons derived from induced pluripotent stem cells (iPSCs) of patients with the E200K prion protein mutation, showing changes in neuron-to-neuron contact sites even in the absence of misfolded prion proteins.
          Read More
          This shows a neuron.
          FeaturedGeneticsNeurologyNeuroscience
          ·December 4, 2023·4 min read

          The Role of Protein Misfolding in Neurodegenerative Diseases

          Neurodegenerative diseases share a common factor: protein misfolding and deposits in the brain. Misfolded proteins can lead to toxic activity or the loss of the protein's physiological function, causing damage to neurons.
          Read More
          FeaturedNeurologyNeuroscience
          ·March 15, 2021·3 min read

          Crucial Step in Formation of Deadly Brain Diseases Discovered

          Study sheds light on what causes normal proteins to convert to a diseased form associated with CJD and Kuru.
          Read More
          tau buildup in brain slices
          FeaturedGeneticsNeurologyNeuroscience
          ·May 1, 2019·9 min read

          Alzheimer’s disease is a ‘double-prion disorder’

          Self-propagating amyloid and tau act as prions in the pathology of Alzheimer's disease. Higher levels of the prions in human brain samples were strongly correlated with early onset of Alzheimer's and death at a younger age.
          Read More
          microglia
          FeaturedNeurology
          ·May 17, 2018·3 min read

          Microglia Are Key Defenders Against Prion Disease

          A new study reveals the role microglia plays in helping to protect the brain against prion infection.
          Read More
          Image shows alpha-synuclein amyloid fibrils.
          FeaturedNeurologyOpen Neuroscience Articles
          ·September 14, 2017·3 min read

          Molecular Link Between Parkinson’s and Prion Diseases Discovered

          Researchers detail the complex interaction between alpha synuclein and the prion protein PrPc.
          Read More
          Image shows prions.
          FeaturedNeurologyOpen Neuroscience Articles
          ·December 14, 2016·4 min read

          Gut Cells Are Gatekeepers For Infectious Brain Diseases

          A new study reports M cells found in the lining of the gut can help to protect the against prion infections.
          Read More
          Image shows a fruit fly.
          FeaturedNeurologyNeuroscience
          ·October 14, 2016·5 min read

          Fruit Fly Model of Brain Disease Could Lead to Blood Test for vCJD

          A new fruit fly model in development could lead to low cost blood tests to help diagnose a deadly prion disease.
          Read More
          Image shows autophagy in action.
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·August 11, 2016·3 min read

          Putting Autophagy Under the Microscope

          Researchers have been able to capture autophagy in super resolution.
          Read More
          Image shows tissue with scrapie.
          FeaturedNeurology
          ·August 9, 2016·4 min read

          Cascade of Events Leading to Prion Disease Described

          A new study describes two distinct stages of prion disease.
          Read More
          Photo of an alzheimer's brain.
          Featured
          ·November 3, 2015·5 min read

          Alzheimer’s May Be a Collection of Different Diseases That Should be Treated Separately

          Researchers report Alzheimer's disease may actually be a collection of different disease that should be treated independently with different approaches.
          Read More
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          This shows a person cleaning their ear.

          Ear Wax Reveals Parkinson’s Disease Biomarkers

          This shows DNA and a brain.

          New Genetic Link to OCD Found

          This shows a group of people.

          Alzheimer’s Risk Linked to Increased Social Activity, Not Isolation

          This shows a man sitting in a room full of post-it notes.

          How Memory and Habits Shape Mental Health Outcomes

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