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Summary: A new fruit fly model in development could lead to low cost blood tests to help diagnose a deadly prion disease.
Source: University of Cambridge.
A new model of fatal brain diseases is being developed in the fruit fly by a team led by Dr Raymond Bujdoso at the University of Cambridge, and could lead to a low cost, fast and efficient blood test to diagnose – and prevent possible transmission of – variant Creutzfeldt-Jakob disease (vCJD).
Currently, methods to detect vCJD-infected human blood samples that involve experimental animals, such as mice, are time consuming and expensive. This new test could potentially be used on blood samples collected during pre-clinical disease and would be able to give a result in a matter of days or weeks rather than months or years.
In the late eighties, the UK saw an outbreak of bovine spongiform encephalopathy (BSE), a fatal brain condition in cattle, often referred to as ‘mad cow disease.’ BSE is a type of neurodegenerative brain condition known as a prion disease, caused by the build-up of a rogue form of a normal protein found in neurons. This aggregated form of the normal protein is referred to as a prion and is infectious. Following the BSE outbreak, a number of people were diagnosed with vCJD, a fatal human prion disease, believed to have occurred through the consumption of BSE-contaminated beef. vCJD causes changes in mood and behaviour, followed by difficulty in walking, and eventually leads to loss of movement and speech before death.
Other cases of vCJD have occurred in patients who received blood products prepared from donors who themselves later developed the disease; hence, blood-borne transmission of vCJD is a major concern for blood transfusion banks, manufacturers of blood plasma-derived products and public health authorities.
Although the number of people known to have died from vCJD is small – less than 180 cases in the UK – recent research has suggested that, within a certain age group of people in the UK, the number of individuals infected with vCJD, but who have not developed clinical signs of the condition, could be as high as one person in 2,000. Whether these individuals will go on to develop the clinical form of the disease during their natural life span remains uncertain.
At the moment, the only reliable way to detect infectious prions in blood is through a test known as a bioassay. This involves injecting suspected infected samples into experimental animals and waiting to see if these recipients develop prion disease. This is usually carried out by injecting potentially prion-infected samples into the brains of mice. These assays are slow and cumbersome, since the incubation time for prion disease may be over a year. This means that very few blood samples are routinely screened for prion infectivity.
Now, in a study published today in the Biochemical Journal, scientists at the University of Cambridge, UK, and the Ecole Nationale Veterinaire de Toulouse, France, report the development of a genetically-modified fruit fly (Drosophila melanogaster) into which a gene has been inserted to make the fly capable of producing the rogue protein that aggregates in the brain of sheep with the prion disease scrapie.
When the researchers fed these transgenic flies plasma from sheep known to have prions in their blood, they found that this caused prion disease in the flies. This response to prion-infected blood was evident within only a few weeks after exposure to the material.
Dr Raymond Bujdoso from the Department of Veterinary Medicine at the University of Cambridge, who led the research, says: “We have found the fruit flies respond so quickly to infected blood that it means we can develop a faster, more versatile and more sensitive test to detect infectious prions in blood than currently exists.
“At the moment, screening blood products for vCJD prion infectivity is just not practical – it is expensive and time consuming, and would require the use of a large number of animals, which is ethically unacceptable. The development of a vCJD blood test that could easily and reliably screen for prion-infectivity would represent an ideal solution for identifying donors and blood donations that might present a risk of causing the disease.”
Fruit flies are relatively easy and economical to work with, and widely accepted to be an ethical alternative to higher organisms such as mice. Dr Bujdoso and colleagues say that their fruit fly model will help contribute to the so-called 3Rs – the replacement, refinement and reduction of the use of animals in research.
Professor David Carling, Chair of the Biochemical Journal, adds: “The paper from Dr Bujdoso and colleagues provides a proof-of-principle study demonstrating that the fruit fly can be used to detect the infectious agent responsible for a type of neurodegenerative disease. Although the work is at a preliminary stage, it offers the exciting possibility of developing a quick and reliable screen for early diagnosis of a devastating disease.”
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Funding: The research was supported by the Isaac Newton Trust and the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs).
Source: Craig Brierley – University of Cambridge Image Source: NeuroscienceNews.com image is adapted from the University of Cambridge press release. Original Research: Abstract for “Bioassay of prion-infected blood plasma in PrP transgenic Drosophila” by Alana M Thackray, Olivier Andreoletti, and Raymond Bujdoso in Biochemical Journal. Published online October 13 2016 doi:10.1042/BCJ20160417
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[cbtabs][cbtab title=”MLA”]University of Cambridge. “Fruit Fly Model of Brain Disease Could Lead to Blood Test for vCJD.” NeuroscienceNews. NeuroscienceNews, 13 October 2016. <https://neurosciencenews.com/cjd-blood-test-5296/>.[/cbtab][cbtab title=”APA”]University of Cambridge. (2016, October 13). Fruit Fly Model of Brain Disease Could Lead to Blood Test for vCJD. NeuroscienceNews. Retrieved October 13, 2016 from https://neurosciencenews.com/cjd-blood-test-5296/[/cbtab][cbtab title=”Chicago”]University of Cambridge. “Fruit Fly Model of Brain Disease Could Lead to Blood Test for vCJD.” https://neurosciencenews.com/cjd-blood-test-5296/ (accessed October 13, 2016).[/cbtab][/cbtabs]
Bioassay of prion-infected blood plasma in PrP transgenic Drosophila
In pursuit of a tractable bioassay to assess blood prion infectivity we have generated PrP transgenic Drosophila , which show a neurotoxic phenotype in adulthood after exposure to exogenous prions at the larval stage. Here we determined the sensitivity of ovine PrP transgenic Drosophila to ovine prion infectivity by exposure of these flies to a dilution series of scrapie-infected sheep brain homogenate. Ovine PrP transgenic Drosophila showed a significant neurotoxic response to dilutions of 10-2 through to 10-10 of the original scrapie-infected sheep brain homogenate. Significantly, we determined that this prion-induced neurotoxic response in ovine PrP transgenic Drosophila was transmissible to ovine PrP transgenic mice, which is indicative of authentic mammalian prion detection by these flies. As a consequence, we considered that PrP transgenic Drosophila were sufficiently sensitive to exogenous mammalian prions to be able to detect prion infectivity in the blood of scrapie-infected sheep. To test this hypothesis we exposed ovine PrP transgenic Drosophila to scrapie-infected plasma, a blood fraction notoriously difficult to assess by conventional prion bioassays. Notably, pre-clinical plasma from scrapie-infected sheep induced neurotoxicity in PrP transgenic Drosophila and this effect was more pronounced after exposure to samples collected at the clinical phase of disease. The neurotoxic phenotype in ovine PrP transgenic Drosophila induced by plasma from scrapie-infected sheep was transmissible since head homogenate from these flies caused neurotoxicity in recipient flies during fly-to-fly transmission. Our data show that PrP transgenic Drosophila can be used successfully to bioassay prion infectivity in blood from a prion-diseased mammalian host.
“Bioassay of prion-infected blood plasma in PrP transgenic Drosophila” by Alana M Thackray, Olivier Andreoletti, and Raymond Bujdoso in Biochemical Journal. Published online October 13 2016 doi:10.1042/BCJ20160417
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