Perineuronal nets (PNNs) and the neurons they enmesh can be damaged by poor diets. Excessive consumption of foods high in saturated fats and refined sugars cause inflammation and oxidative stress, resulting in cognitive decline and poor memory.
Researchers report vitamin D levels affect perineuronal nets in the hippocampus. The study found vitamin D deficiency resulted in a significant decline in memory and learning in mouse models.
Researchers have solves a longstanding mystery relating to perineuronal nets, giving rise to potential new treatments for epilepsy. The study reports the nets modulate electrical impulses in the brain and seizures can occur if perineuronal networks are dissolved.
Researchers identify a new mechanism that contributes to learning an association between a warning noise and a fearful event.