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p53

Neurons are shown. Caption describes it well.

·October 22, 2012·3 min read

Aggressive Brain Tumors Can Originate from a Range of Nervous System Cells

Scientists have long believed that glioblastoma multiforme, the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. Researchers found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

Featured Genetics Neuroscience

·September 12, 2018·3 min read

Aging May Be As Old As Life Itself

Researchers report that, at the molecular levels, aging may have originated at the beginning of the evolution of life. They suggest when it comes to genes, aging may not always be a negative trait, and may help an organism to survive.

Featured Neurology Open Neuroscience Articles

·October 12, 2016·5 min read

Amplifying Regeneration of Spinal Nerve Cells

Researchers have been able to successfully boost the regeneration of mature nerve cells in the spinal cord of adult mice following spinal cord injury.

Brain Cancer Featured Genetics Neurology Neuroscience

·July 10, 2025·4 min read

Cancer Pathway Found to Weaken Brain and Eye Barriers

Researchers have uncovered a surprising connection between a cancer-related signaling pathway and the blood-brain and blood-retina barriers. The study shows that the tumor-suppressing protein p53 weakens the Norrin/Frizzled4 pathway, which is crucial for maintaining these protective barriers.

Featured Genetics Neuroscience Open Neuroscience Articles

·December 7, 2015·5 min read

Designer Dopamine Neurons Within Reach

Researchers have discovered a new method to ramp up the conversion of skin cells to dopamine neurons.

Featured Genetics Neurology

·May 22, 2017·5 min read

Experimental Therapy for Immune Diseases Hits Achilles Heel of Activated T Cells

PPCA treatment shown to provide therapeutic benefit in mouse models of hemophagocytic lymphohistiocytosis and multiple sclerosis.

Featured Genetics Neurology Open Neuroscience Articles

·September 12, 2016·5 min read

Genetic Causes of Microcephaly Share Common Mechanism

Researchers believe new study may help improve understanding of the genetic causes of microcephaly and other neurodevelopmental disorders.

Featured Genetics Neuroscience

·July 19, 2022·4 min read

Going to the Beach? Planning a Hike? Be Prepared: Men Will Be Much Hungrier!

In males, sun exposure activates the p53 protein which signals to the body to produce the appetite-associated ghrelin hormone. In women, estrogen blocks the interaction between p53 and ghrelin, reducing the urge to eat following sun exposure.

The image shows an MRI scan of a patient with brain cancer. The tumor is highlighted in blue.

Brain Cancer Featured

·May 14, 2013·4 min read

New Drug Enhances Radiation Treatment for Brain Cancer in Preclinical Studies

A new drug could help increase the effectiveness of radiation therapy for patients with glioblastoma multiforme, the most deadly form of brain cancer. The ATM kinase inhibitor, in combination with radiation therapy, helped significantly extend survival rates in mouse models of GBM.

Brain Cancer Featured Genetics Neurology Open Neuroscience Articles

·April 25, 2018·4 min read

Organoids Reveal how Deadly Brain Cancers Grow

Researchers use gene editing to generate aggressive glioblastoma multiforme brain tumors in the lab. The model, researchers say, could be used to track the progression of tumors and develop personalized therapies for patients.