Researchers have identified a brain circuit that drives physical response to emotional stress. The circuit begins in the dorsal peduncular cortex and dorsal tenia tecta, before sending signals to the hypothalamus. The findings could help with the development of treatments for panic disorders and PTSD.
Researchers genetically engineered neurons to produce a newly developed, light-sensitive protein called SOUL. They then used optogenetic technology to shine a light through the skull and alter neural responses through an entire mouse brain.
Researchers use optogenetic based deep brain stimulation to help treat motor dysfunction in animal models of Parkinson's disease. The new technique provides insights into why DBS works and ways in which it can be improved on a patient-by-patient basis.
Study reveals how serotonin plays a key role in the scaling of current sensory input and outgoing brain signals.
Hippocampal neurons that store abstract memories of prior experiences activate when new, but similar events take place.
Novelty directly activates the dopamine system and enhances associative learning. The findings have implications for the development of new machine learning technologies and educational strategies.
Nucleus papilion neurons play an important role in eye movement during REM sleep.
Using optogenetics to dampen delta waves of rats during sleep resulted in weaker memory reactivation and promoted forgetting. The findings could have significant implications for treating PTSD in humans.
Researchers have identified a comprehensive circuit mechanism that governs how emotional states can influence movement through connections in the basal ganglia. The mechanism represents a way in which emotional states relate to changes in action control in depression, anxiety, and OCD.
Enhanced reactivation of negative memory engrams may be an important cellular mechanism behind the cognitive symptoms of depression.