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OLIG2

This shows a medulloblastoma in a brain scan

Brain Cancer Featured Genetics Neurology Neuroscience

·August 29, 2019·4 min read

Cracking the code of a brain cancer that keeps coming back

Using computer assisted technology to map cell types and molecular cascades, researchers have discovered potential new treatment strategies for recurrent Sonic Hedgehog Medulloblastoma.

Featured Genetics Neuroscience

·May 23, 2019·3 min read

Targeting key gene could help lead to down syndrome treatment

Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development.

Featured Genetics Neurology Neuroscience

·May 1, 2019·5 min read

Restoring brain function in mice with symptoms of Alzheimer’s disease

Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.

Featured Genetics Neuroscience Open Neuroscience Articles

·February 5, 2018·3 min read

Gene Network That Regulates Motor Neuron Formation During Embryonic Development Identified

Researchers have identified a gene network that regulates the development of motor neurons during embryonic development.

Image shows brain cells expressing Olig2.

Brain Cancer Featured

·May 9, 2016·5 min read

Experimental Therapy Halts Treatment Resistant Brain Tumors

Researchers report an experimental treatment has shown to be able to stop treatment resistant glioblastoma in human cells and mouse models.

Image shows MRI scans of a mouse brain tumor.

Brain Cancer Featured

·November 1, 2015·4 min read

New Computational Strategy Finds Brain Tumor Shrinking Molecules

According to a new study, computer modeling has been able to identify a molecule which inhibits a transient cellular event that drives glioblastoma brain cancer.