Familial hemiplegic migraine type 2 (FHM2) causes a malfunction of astrocytes in the cingulate cortex. Manipulating astrocytes in the cingulate cortex reversed the disfunction, preventing an increase in migraine-like symptoms in mice carrying the FHM2 defect.
NMDA receptor hypofunction is involved in the reduction of sleep spindles and delta oscillations, which appear in the brain during deep natural sleep. Findings confirm the role NMDA receptors play in sleep disorders that accompany psychotic states.
A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months.
Bilirubin, a bile pigment most commonly associated with jaundice in newborns, appears to have neuroprotective properties. A new study in mice reveals bilirubin may protect the brain against oxidative stress.
A new study clarifies the mechanism behind how ketamine works as an antidepressant. Researchers say there is evidence to suggest ketamine binds to NMDA receptors, instead of opioid receptors. Reducing the belief that ketamine is an opioid may make patients with depression more open to using the treatment.
A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death.
In response to injury, microglia cross the spinal boundary from the central nervous system to the peripheral nervous system. While in the PNS, microglia provide the function of clearing cellular debris at the point of injury, then return to the CNS in an altered state. Researchers propose this could account for some damage associated with neurodegenerative diseases.
Study reveals a motif on the 93-series compound fits into a tiny pocket within the NMDA receptor. The findings could lead to new treatment options for stroke and seizures, researchers report.
According to a new mathematical model of seizures, only the conductivity of the AMPA receptors in neurons in the temporal lobe significantly change, leading to stronger excitation and synaptic signals.
Researchers report ketamine's antidepressive effects require activation of opioid receptors in the brain. The study highlights the interaction between depression, pain and opioid addiction.