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Featured Genetics Neurology Open Neuroscience Articles

·June 24, 2020

Genetic malfunction of brain astrocytes triggers migraine

Familial hemiplegic migraine type 2 (FHM2) causes a malfunction of astrocytes in the cingulate cortex. Manipulating astrocytes in the cingulate cortex reversed the disfunction, preventing an increase in migraine-like symptoms in mice carrying the FHM2 defect. Read More

Featured Neuroscience Psychology

·June 5, 2020

NMDA receptors may link psychosis and sleep deficits

NMDA receptor hypofunction is involved in the reduction of sleep spindles and delta oscillations, which appear in the brain during deep natural sleep. Findings confirm the role NMDA receptors play in sleep disorders that accompany psychotic states. Read More

Featured Genetics Neuroscience Open Neuroscience Articles

·March 11, 2020

JNK protein triggers neurons to withdraw their synapses when stressed

Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress. Read More

This shows synaptic transmission in action

Featured Neuroscience Open Neuroscience Articles Psychology

·February 24, 2020

Antibodies: The body’s own antidepressants

When autoantibodies are able to enter the bran and act on NMDA receptors, people experience relief from symptoms of anxiety, depression, and stress. Read More

Featured Neuroscience Open Neuroscience Articles

·November 26, 2019

One shot of ketamine could reduce problem drinking

A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months. Read More

Featured Neurology Neuroscience

·August 16, 2019

More Than Just Jaundice: Bilirubin May Protect The Brain

Bilirubin, a bile pigment most commonly associated with jaundice in newborns, appears to have neuroprotective properties. A new study in mice reveals bilirubin may protect the brain against oxidative stress. Read More

Featured Neuroscience Psychology

·July 31, 2019

Ketamine isn’t an opioid and treats depression in a unique way

A new study clarifies the mechanism behind how ketamine works as an antidepressant. Researchers say there is evidence to suggest ketamine binds to NMDA receptors, instead of opioid receptors. Reducing the belief that ketamine is an opioid may make patients with depression more open to using the treatment. Read More

Featured Neurology Neuroscience

·July 10, 2019

Brain on Fire: Puzzling brain disease could now be better diagnosed and treated

A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death. Read More

This image shows microglia passing from the CNS to PNS

Featured Neuroscience Open Neuroscience Articles

·April 7, 2019

Microglia, cells thought restricted to central nervous system, are redefined in new study

In response to injury, microglia cross the spinal boundary from the central nervous system to the peripheral nervous system. While in the PNS, microglia provide the function of clearing cellular debris at the point of injury, then return to the CNS in an altered state. Researchers propose this could account for some damage associated with neurodegenerative diseases. Read More

Featured Neurology Open Neuroscience Articles

·January 20, 2019

Targeting ‘Hidden Pocket’ For Treatment of Stroke and Seizure

Study reveals a motif on the 93-series compound fits into a tiny pocket within the NMDA receptor. The findings could lead to new treatment options for stroke and seizures, researchers report. Read More

Featured Neurology Open Neuroscience Articles

·January 7, 2019

New Key Mechanism of Epileptic Seizures Revealed

According to a new mathematical model of seizures, only the conductivity of the AMPA receptors in neurons in the temporal lobe significantly change, leading to stronger excitation and synaptic signals. Read More

Featured Neuroscience Psychology

·August 29, 2018

Ketamine’s Antidepressant Effects Tied to Opioid System in the Brain

Researchers report ketamine's antidepressive effects require activation of opioid receptors in the brain. The study highlights the interaction between depression, pain and opioid addiction. Read More

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