CSHL structural biologists reveal molecular architecture of key NMDA receptor subunit Structure of GluN2D subunit when docked with certain neurotransmitters...
Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant like ketamine. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say NIH researchers.
in a mouse model of Rett syndrome, researchers were able to reverse abnormalities in brain activity and improve neurological function by treating animals with an FDA-approved anesthesia drug, ketamine.
The findings in fruit fly larvae demonstrate the first known function for the sensory neurons and provide insights that could broaden the understanding of chronic pain syndromes in humans.
In a promising finding for epileptic patients suffering from persistent seizures known as status epilepticus, researchers reported today that new medication could help halt these devastating seizures.
Researchers upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons. The study describes how a compound linked to Alzheimer's disease impacts NMDA receptors and weakens synaptic connections between brain cells.
A new study provides clues into how the function of the most common NMDA receptor subtypes may be manipulated for clinical benefit. NMDA receptors have been implicated in a number of neurological and psychological disease, from Alzheimer's to schizophrenia.
Researchers discover a new phase of synaptic development. The finding could lead to a better understanding of how learning and memory occur.
A new study funded by the NIMH suggests GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the negative side effects of the well known street drug.
A new study has identified neural circuits in mice which are involved in the learning and altering of behaviors. The findings could have implications for alcoholism and other addictive behaviors.