Researchers implanted specialized neural stem cell grafts directly into mice with spinal cord injuries. As the grafts grew, they integrated with and mimicked the animal's existing neural network.
The genes GRB10 and ABTB1 are influential in nutrient-sensing pathways and memory. Researchers say these genes may be the molecular links between diet, neural stem cell aging, and cognitive ability.
Researchers have created a new technique that can rapidly "print' two-dimensional arrays of cells and proteins that mimic a variety of cellular environments in the body.
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The olfactory epithelium may be a hub for neurogenesis.
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Vimentin, a cellular filament, helps neural stem cells to clear damaged and clumped proteins, assisting in neurogenesis.
Researchers define the proteome of neural stem cell niches and the entire set of expressed proteins. The findings shed light on key regulators of neurogenesis.
A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation.
Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.
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The FGF signaling pathway is an important extracellular regulator in the fate of neural stem cells switching from neurons to astrocytes in the cerebral cortex.
Eating processed food which contains Propionic Acid (PPA) during pregnancy may affect neural stem cell development in the fetal brain. Excessive PPA reduces the number of neurons and over-produces glial cells, causing inflammation. Additionally, PPA shortens neural pathways. The combination of damaged pathways and reduced neurons may be associated with behavioral deficits associated with ASD.
Awakening dormant stem cells could stimulate the growth of new neurons. The findings could have significant implications for the treatment of neurodegenerative diseases.
A new study in fruit fly models reveals STRIPAK components act as a switch to turn off quiescence and turn on the reactivation of neural stem cells.