Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.
Genetically embedded tools in neural stem cells may aid in development of regenerative medicine – critical for safe and reliable...
Scientists have long believed that glioblastoma multiforme, the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. Researchers found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.
A new method for obtaining mature neuronal cells from reprogrammed skin cells allows researchers to safely and effectively study diseases such as schizophrenia and autism.
According to a new study, adult neural stem cells appear to be programmed prior to birth to make specific types of neurons.
Neuroscience researchers show how astrocytes control the generation of new neurons in the brain. “In the brain, astrocytes control how many new neurons are formed from neural stem cells and survive to integrate into the existing neuronal networks. Astrocytes do this by secreting specific molecules but also by much less understood direct cell-cell interactions with stem cells”, says Prof. Milos Pekny.
Mitochondria regulate how neural stem cells become neurons during brain development. The findings may help explain how humans developed larger brains during evolution and how mitochondrial defects lead to some neurodevelopmental disorders.