In adults, levels of GDF11, a gene that is key to the regeneration of murine neural stem cells, are inversely related to depressive episodes. Administering the GDF11 proteins to aging mice reduced depressive states and improved cognition.
After discovering the importance of cell metabolism in neurogenesis, researchers were able to increase the number of neurons in the brains of adult and elderly mice.
Study reveals how neurons and glial cells contribute to drive neurodegeneration following brain injury.
A new study sheds light on how the neocortex in the human brain develops.
INSR, a protein essential for insulin activity, plays a critical role in stem cell longevity. Additionally, inactivating INSR in glioblastoma brain cancer stem cells inhibits the growth of primitive tumor forming cells.
Hippocampal neurogenesis and cognitive function were improved in aging mice by destroying senescent cells in the aging stem cell niche.
Grafting neurons derived from a monkey's own stem cells reversed the debilitating and mental health symptoms associated with Parkinson's disease. The treatment shows promise for alleviating the symptoms of Parkinson's in humans.
Increasing lamin B1 levels in aging mice resulted in neural stem cell division and an increase in the number of new neurons.
Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.
FOXO3, a gene linked to longevity in humans, protects neural stem cells from the negative effects of stress.
The brain enzyme Pr-set7 activates dormant neural stem cells.
Mitochondria regulate how neural stem cells become neurons during brain development. The findings may help explain how humans developed larger brains during evolution and how mitochondrial defects lead to some neurodevelopmental disorders.
