Women who have been pregnant were diagnosed with their first multiple sclerosis symptoms, on average, 3.3 years later than women with MS who had never become pregnant. Read More
Specific combinations of microorganisms in the gut can worsen symptoms of multiple sclerosis in mouse models of the autoimmune disease. Read More
eEF1a1 activated by acetylation prevents remyelination, but if the protein is deactivated by deacetylation, myelin sheaths can be rebuilt. The findings shed light on the process of remyelination and could provide avenues of treatment for multiple sclerosis, and other conditions associated with demyelination. Read More
Decreasing the amount of Reelin significantly protected against disease symptoms and promoted recovery in symptomatic animal models of multiple sclerosis. Reelin levels appear to correlate with MS severity and stages. Researchers report lowering levels of the protein could be a potential avenue of treatment for the autoimmune disorder. Read More
Those with MS allocate neural resources less effectively when faced with increased cognitive task demands, and this likely results in the increased mental fatigue those with the neurodegenerative disorder experience. Read More
Multiple sclerosis patients are nine times more likely to discuss the use of alternative medicines, including cannabis, with their neurologists as treatment options than they were in 2001. 81% of MS patients report the use of dietary supplements to help with disease management, and 39% report participating in mindfulness and other mind-body therapies. 30% of patients reported using marijuana to help treat their symptoms. Read More
Higher levels of air pollution associated with urban living could put people at a 29% increased risk of multiple sclerosis. Read More
A new blood test can help predict which patients with multiple sclerosis will see a decline in their condition over 12 months. The test looks for a biomarker called neurofilament light chain, a protein that can be detected as nerve cells die. People with higher levels of the protein were 40-70% more likely to experience worsening symptoms over a year than those with lower levels. Read More
Human iPSCs transplanted into animal models of multiple sclerosis help repair cell damage and restore function. Read More
In late-stage multiple sclerosis, inflammatory cells no longer enter the brain via the bloodstream, but instead the cells arise in memory from local memory cells inside the brain. The findings suggest during the late phases of multiple sclerosis, the disease is occurring entirely inside the brain. Read More
A new method called Tox-seq found only one sub-group of microglia caused oxidative stress. The gene expression signatures of this sub-group from a mouse model matched patterns observed in cells suspected of causing damage in progressive multiple sclerosis patients. The pattern of gene expression associated with oxidative stress in mouse cells included genes involved in coagulation. Read More
Ursolic acid, a compound abundant in fruit peels and some herbs, appears to decrease further neural damage and help regenerate myelin in mouse models of multiple sclerosis. Study reveals ursolic acid suppresses TH17 cells, which are one of the main drivers in the pathological autoimmune response of MS. Read More
