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McLean Hospital

·September 12, 2024·4 min read

High Doses of ADHD Meds Linked to Increased Psychosis Risk

Adults taking high doses of amphetamine-based medications for ADHD, such as Adderall, face a five-fold increased risk of developing psychosis or mania. The risk was highest for those taking 30 mg or more of dextroamphetamine, with 81% of psychosis or mania cases potentially avoidable by lowering the dose.

Featured Genetics Neuroscience Psychology

·May 24, 2024·9 min read

Brain Molecular Changes In PTSD and Depression Revealed

A new study reveals shared and distinct molecular changes in the brain and blood of individuals with PTSD and MDD. The research uncovers how these disorders affect various brain regions, cell types, and genomic layers, highlighting key molecular pathways and potential biomarkers.

Featured Genetics Neuroscience Psychology

·May 24, 2024·6 min read

Study Maps Genetic Risk of Schizophrenia to Specific Brain Cells

A new study uncovers the intricate molecular mechanisms behind schizophrenia by mapping genetic risk factors to specific brain cells. Researchers used comprehensive genetic and cellular analyses to identify how these genes affect different cell types in the prefrontal cortex.

Featured Genetics Neuroscience Psychology

·July 26, 2023·5 min read

Investigating Stress Response in PTSD and Depression Through Gene Analysis

Researchers conducted an analysis of genes in nearly 575,000 brain cells from individuals with and without post-traumatic stress and major depressive disorders (PTSD and MDD), yielding new insights into the brain's stress response. The study identifies varying gene expression levels in the dorsolateral prefrontal cortex (DLPFC) region among PTSD, MDD, and unaffected individuals.

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Featured Neuroscience Psychology

·November 3, 2022·4 min read

Study Sheds New Light on Brain Activity Related to Dissociative Symptoms

Dissociation often occurs following trauma, and affects more women than men. A new study found different dissociative symptoms are uniquely associated with connections in areas of brain networks linked to cognition and emotional processing.

Featured Neuroscience Psychology

·June 19, 2021·2 min read

Details Behind the Body’s Response to Stress Revealed

Study reveals how key proteins regulate the brain's response to stress in the hippocampus.

Featured Genetics Neuroscience Psychology

·October 31, 2020·3 min read

Neuron-Based Gene Expression Study Reveals Insights on Fear and Its Regulation

The expression of the CREB gene may function as a switch to regulate fear and extinction learning. The findings could provide a new avenue of treatment for PTSD and other mental health disorders.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·June 2, 2020·3 min read

Expression of certain genes may affect vulnerability to PTSD

People with PTSD tend to have higher expression of the SNRNP35 gene in their brains, and lower ZNF140 gene expression in their blood.

Featured Neuroscience Open Neuroscience Articles Psychology

·October 17, 2019·5 min read

Investigating the full spectrum of suicide

Studying self-injury mortality (SIM) allows for the closer study of suicide trends and drug overdose deaths.

This shows a brain with pinwheels and different brain areas in them

Featured Neuroscience Open Neuroscience Articles Psychology

·May 13, 2019·4 min read

Researchers seek ‘fingerprints’ of severe mental diseases

Neuroimaging study finds significant changes in the brain associated with mental illnesses that could serve as a biomarker for diagnosis.

Featured Neuroscience Psychology

·March 2, 2019·5 min read

How Sensitivity to Emotions Changes Across the Lifespan

Researchers report sensitivity to anger cues improve during adolescence, but decreases as we age. However, the ability to detect happy cues remains the same, regardless of age.

Featured Neurology Open Neuroscience Articles

·April 29, 2018·4 min read

Lipid Accumulation in Brain May Be an Early Sign of Parkinson’s

Researchers report the accumulation of glycosphingolipids in the substantia nigra appears to be elevated in Parkinson's disease patients. The finding could be used as a biomarker for helping diagnose Parkinson's before symptoms of the disease set in.

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McLean Hospital

High Doses of ADHD Meds Linked to Increased Psychosis Risk

Brain Molecular Changes In PTSD and Depression Revealed

Study Maps Genetic Risk of Schizophrenia to Specific Brain Cells

Investigating Stress Response in PTSD and Depression Through Gene Analysis

Study Sheds New Light on Brain Activity Related to Dissociative Symptoms

Details Behind the Body’s Response to Stress Revealed

Neuron-Based Gene Expression Study Reveals Insights on Fear and Its Regulation

Expression of certain genes may affect vulnerability to PTSD

Investigating the full spectrum of suicide

Researchers seek ‘fingerprints’ of severe mental diseases

How Sensitivity to Emotions Changes Across the Lifespan

Lipid Accumulation in Brain May Be an Early Sign of Parkinson’s

Chronic Back Pain Makes the World Sound Harsher

Why the Brain and Breath Part Ways During Heavy Slumber

Brain’s “On-Switch” for Imagination Found

AI Decodes the “Brain Fingerprint” of Chronic Pain

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