LTP

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LTP

·March 8, 2023·4 min read

How Gene Expression Controls Synaptic Plasticity in the Aging Human Brain

M1 muscarinic acetylcholine receptor (mAChR) dependent LTP and LTD share a common AMPA trafficking pathway. Either the upregulation of neurotransmitter receptor genes or suppression of the downregulation could improve synaptic dysfunction associated with age-related neurodegeneration. The findings could assist in the creation of new therapies for Alzheimer's disease that target synaptic plasticity.

Featured Neuroscience Psychology

·August 2, 2022·6 min read

Psychedelic Drugs’ Therapeutic Potential for a Range of Psychiatric Disorders

Researchers discuss how psychedelics can affect the brain and provide therapeutic benefits for those suffering from a range of psychiatric disorders.

Featured Neuroscience

·November 13, 2021·3 min read

A New Neural-Optic System Can Manipulate Memories

A new neuro-optics technique can manipulate memory consolidation in mouse models by hindering long-term potentiation. Researchers say eliminating local LTP in the hippocampus erased memories. The method could be used to isolate memory formation at the cellular level.

Featured Neuroscience Open Neuroscience Articles

·October 4, 2020·5 min read

How Aggression Leads to More Aggression

Hard wired neural circuits in mice that govern aggression are strengthened following victories in aggressive encounters. Synapses in the hypothalamus show signs of LTP following aggression training.

Featured Neuroscience Open Neuroscience Articles

·August 26, 2020·4 min read

Unlocking the Mysteries of the Brain

Researchers have made an important discovery about the mechanisms behind learning and memory. Depending on the number of synapses, and their proximity, information is processed and stored differently.

Featured Neuroscience Open Neuroscience Articles

·July 21, 2020·5 min read

Scientists Observe Learning Processes Online in the Brain

Repeatedly administered tactile simulation over a sustained period of time alters neural processing of the hand area in the brain. The observable changes over time illustrate neuroplasticity and shed new light on the process of learning.

Featured Neurology

·July 20, 2020·4 min read

Oxytocin Could Be Used to Treat Cognitive Disorders Like Alzheimer’s

Oxytocin, the so-called "love hormone," could help to treat cognitive disorders, including Alzheimer's disease. Researchers demonstrated oxytocin reversed the effects of amyloid-beta on hippocampal LTP in mice. The findings suggest oxytocin could be used as a therapeutic for the treatment of Alzheimer's disease and other dementias.

This shows an eraser removing a drawing of a brain

Featured Neurology Neuroscience Open Neuroscience Articles

·March 3, 2020·6 min read

Visceral fat delivers signal to the brain that hurts cognition

Visceral fat impairs memory via proinflammatory interleukin-1 beta mediated microglia activation in the hippocampus.

Featured Neuroscience Open Neuroscience Articles

·October 17, 2019·3 min read

Fundamental insight into how memory changes with age

New memories are laid down via different mechanisms in older mice compared to younger mice. Additionally, synaptic changes linked to new memory formation were harder to modify in older mice.

Featured Neurology Neuroscience

·August 29, 2019·4 min read

Lack of oxygen doesn’t kill infant brain cells, as previously thought

A lack of oxygen as a result of preterm birth does not cause hippocampal neurons to die but does impair hippocampal development. Hypoxia causes hippocampal cells to fail to mature normally, causing a reduction in long-term potentiation and impaired learning.

Featured Neuroscience Open Neuroscience Articles

·August 12, 2019·3 min read

Calcium is key to age-related memory loss

Mouse study reveals a clear correlation between cognitive ability in aging and presynaptic calcium levels.

A detailed drawing of the hippocampal formation is shown.

Electrophysiology Featured Neuroscience

·March 27, 2019·6 min read

Quick thinking? It’s all down to timing

A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours.

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