ketamine

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ketamine

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·January 5, 2021·6 min read

Repeated Ketamine Infusions Reduce PTSD Symptom Severity

A series of ketamine infusions reduced PTSD symptoms by up to 30% from baseline compared to treatment with midazolam, which reduced symptoms by 20% over the same period. Ketamine treatment significantly reduced three of four PTSD associated symptoms, including intrusive thoughts, avoidance, and negative alterations in cognition and mood. Read More

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·December 28, 2020·4 min read

New Antidepressants Can Lift Depression and Suicidal Thoughts Fast, but Don’t Expect Magic Cures

With the risk of potential for abuse, some new fast-acting antidepressants, like Ketamine, may not be a magic "cure-all" for depression. Read More

Featured Neuroscience Psychology

·December 16, 2020·4 min read

How Does Ketamine Combat Depression?

4E-BPs proteins are key to unlocking ketamine's antidepressant effects. When 4E-BPs are absent in neurons, ketamine can not produce its antidepressant effect. Read More

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Featured Neuroscience Open Neuroscience Articles Psychology

·October 26, 2020·5 min read

Single Brain Region Links Depression and Anxiety, Heart Disease, and Treatment Sensitivity

Overactivity in the subgenual anterior cingulate cortex underlies several key symptoms of depression, anxiety, and heart disease. Read More

Deep Learning Featured Neuroscience Psychology

·September 29, 2020·5 min read

Computer Model Explains Altered Decision Making in Schizophrenia

Summary: An artificial neural network has identified a potential mechanism for the impaired decision-making often seen in schizophrenia patients, which involves the reduced activity of NMDA receptors. Read More

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Electrophysiology Featured Neuroscience Psychology

·September 16, 2020·6 min read

Brain Circuitry Underlying Dissociative Experiences Identified

Researchers have identified a key neural circuit that plays a role in dissociation, a phenomenon in which people can feel disconnected from their bodies and reality. Read More

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·June 11, 2020·5 min read

High doses of ketamine can temporarily switch off the brain

Higher doses of ketamine administered to sheep completely reduced brain activity for a short period. Researchers report as the drug wore off and consciousness was regained, the animals' brain activity switched between high and low-frequency oscillations. The timing of the brain activity corresponds to the time human users report experiencing feelings that their brain 'disconnected' from their bodies after ketamine use. Read More

Featured Neuroscience Psychology

·June 5, 2020·3 min read

NMDA receptors may link psychosis and sleep deficits

NMDA receptor hypofunction is involved in the reduction of sleep spindles and delta oscillations, which appear in the brain during deep natural sleep. Findings confirm the role NMDA receptors play in sleep disorders that accompany psychotic states. Read More

Featured Neuroscience Open Neuroscience Articles Psychology

·June 1, 2020·4 min read

How ketamine combats depression

Ketamine increases the number of serotonin 1B receptors. Ketamine binds to serotonin 1B receptors, reducing the release of serotonin and increasing the release of dopamine. Read More

Featured Neuroscience Open Neuroscience Articles Psychology

·April 26, 2020·4 min read

Effects of rapid-acting antidepressant ketamine consolidated in sleep?

Brain connections strengthened with treatment from fast-acting antidepressants, such as ketamine, are consolidated during deep sleep. Researchers propose rapid antidepressant treatments share the ability to regulate both synaptic potentiation and homeostatic mechanisms, which may contribute to how the brain reorganizes its activity to defeat depression. Read More

Featured Genetics Neuroscience Open Neuroscience Articles

·March 11, 2020·2 min read

JNK protein triggers neurons to withdraw their synapses when stressed

Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress. Read More

Featured Neuroscience Open Neuroscience Articles

·November 26, 2019·5 min read

One shot of ketamine could reduce problem drinking

A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months. Read More

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