ketamine

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ketamine

This shows a man holding his back in pain

·January 30, 2023·5 min read

How Ketamine Acts as Antidepressant in Chronic Pain

Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.

Featured Neuroscience Psychology

·January 9, 2023·12 min read

The Rebirth of Psychedelic Medicine

Often considered dangerous, mind-altering drugs, researchers are turning to the study of psychedelic therapies as a potential to treat an array of psychiatric conditions including depression and PTSD.

Featured Neuroscience Psychology

·December 30, 2022·4 min read

Ketamine Found to Increase Brain Noise

By inhibiting NMDA receptors, ketamine increases noise to gamma frequencies in one layer of the thalamic nucleus and one lay of the somatosensory cortex. Findings suggest psychosis may be triggered by an increase in background noise impairing thalamocortical neurons which may be caused by a malfunction in NMDA receptors affecting the balance of inhibition and excitation in the brain.

This shows a finger touching a drawing of a brain

Featured Neuroscience

·December 2, 2022·4 min read

How Ketamine Acts as a ‘Switch’ in the Brain

Ketamine alters neural activity in the cerebral cortex, silencing normally active neurons and activating neurons that are normally inactive. The ketamine activity-induced "switch" in brain regions associated with depression may help explain its treatment effects.

Featured Neuroscience Psychology

·October 6, 2022·5 min read

Mechanism for the Antidepressant Effect of Ketamine Revealed

Those with treatment-resistant depression showed significant improvement in symptoms and became more receptive to positive experiences following a one-week ketamine treatment regimen.

Featured Neuroscience Psychology

·September 21, 2022·4 min read

Looking at Images of People Smiling at You Extends Antidepressant Effects of Ketamine

Automated computer-based training that focuses on positive words and images helps prolong the antidepressant effects of ketamine for those with treatment-resistant depression.

Featured Neuroscience

·August 30, 2022·5 min read

Drugs Effects of Ketamine in Mice Can Depend on the Sex of the Human Experimenter

Mice respond better to the antidepressant effect of ketamine when the drug is delivered by men, not women, a new study reports.

Featured Neuroscience Open Neuroscience Articles Psychology

·June 1, 2022·4 min read

Why Ketamine Is a Speedster Antidepressant

Ketamine's rapid action as an antidepressant is a result of increasing the activity of a small number of newborn neurons, which are part of ongoing neurogenesis in the brain.

Featured Neuroscience Psychology

·May 31, 2022·6 min read

Study Sheds New Light on a Promising Antidepressant

Ketamine's antidepressant effect is a result of the enhancement of Kcnq2 potassium channels in a certain subtype of glutamate-sensitive neurons.

Featured Neuroscience Open Neuroscience Articles Psychology

·May 25, 2022·3 min read

Using Ketamine to Find an Undiscovered Pathway in Depression

Ketamine treatment leads to an increase in IGF-1, which, in turn, produces an antidepressant effect.

This shows a woman with lines surrounding her

Featured Neuroscience Psychology

·March 18, 2022·4 min read

Researchers Explore Therapeutic Uses of Ketamine

Researchers report ketamine may have a broader use for the treatment of psychological disorders beyond a treatment for depression and anxiety.

Featured Neuroscience Psychology

·January 31, 2022·5 min read

Perception Study May Explain Promising Depression Therapy

Study demonstrates the importance of a specific type of connection between neurons and may also explain how ketamine shows promise in treating depression.

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