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ketamine

·May 19, 2026·16 min read

Buprenorphin and Ketamine Combo Provide Anti-Suicidal Effect

A sequential combination of a single ketamine infusion followed by four weeks of low-dose daily buprenorphine successfully extends the antisuicidal window of ketamine from one fleeting week to over a month.

Featured Neuroscience Psychology

·May 1, 2026·11 min read

How Scientists Cracked the Ketamine Code for Depression

By "reverse engineering" ketamine, Weill Cornell investigators have identified a specific opioid receptor pathway and a unique receptor "cross-talk" that drives rapid antidepressant effects.

Featured Neuroscience Psychology

·March 30, 2026·8 min read

Blocking NOX-1 Extends Ketamine’s Effectiveness for Depression

Researchers have identified the NOX-1 enzyme as the reason ketamine's antidepressant effects are short-lived. By blocking NOX-1, they extended the drug's benefits from days to weeks.

This shows PET scan images of the brain in response to ketamine.

Featured Neuroscience Psychology

·March 6, 2026·8 min read

Ketamine Restores Plasticity via AMPA Receptors

For the first time, scientists have visualized the molecular changes in the human brain that explain why ketamine works so quickly to treat depression.

Neuroscience

·February 28, 2026·7 min read

Ketamine Revolution: Study Redefines Depression Treatment

Pioneering research into ketamine has moved depression treatment away from slow-acting serotonin drugs toward rapid-acting glutamate therapy.

Featured Neuroscience Psychology

·October 22, 2025·8 min read

Ketamine Fails to Outperform Placebo in Major Depression Trial

A large randomized and blinded clinical trial has found no additional benefit of repeated ketamine infusions over standard inpatient care for treating major depression. The study compared ketamine with a psychoactive placebo and found no meaningful differences in objective or self-reported depression scores, cognition, or quality of life.

Featured Neuroscience Psychology

·June 20, 2025·6 min read

Ketamine Plus Therapy Offers Lasting Relief for Severe Depression

A first-of-its-kind clinical trial shows that ketamine treatment for severe, treatment-resistant depression is significantly more effective when paired with psychotherapy and supportive environments. Patients who underwent this combined treatment reported a 30% drop in depression symptoms, with reduced anxiety and suicidal thoughts lasting at least eight weeks.

Featured Neuroscience Psychology

·May 24, 2025·4 min read

Boosting Ketamine’s Antidepressant Effects to Last Two Months

Ketamine is a fast-acting antidepressant that can relieve symptoms of major depressive disorder (MDD) within hours, even in treatment-resistant cases. However, its effects typically last only a week, and frequent dosing poses risks like dissociation or addiction.

Featured Neurology Neuroscience

·May 12, 2025·6 min read

Brain Wave Phase Locking May Be Key to Unconsciousness

Despite acting through different molecular mechanisms, ketamine and dexmedetomidine both disrupt brain wave phase alignment in ways that reliably induce unconsciousness. A new study reveals that these anesthetics trigger a common signature: increased phase locking at low frequencies, particularly between brain hemispheres, while disrupting local cortical communication.

Featured Neuroscience Psychology

·April 29, 2025·6 min read

Ketamine’s Hidden Physical and Psychological Damage

A new study highlights the severe physical and psychological consequences linked to ketamine addiction, with many users unaware of the risks until dependent. Researchers found high rates of bladder damage, painful organ cramps, low mood, and anxiety among those with ketamine use disorder.

Featured Neuroscience Psychology

·February 14, 2025·4 min read

How Ketamine Binds to Brain Receptors to Alter Mood

New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D. Scientists used electron cryo-microscopy to capture how ketamine binds to this receptor, revealing multiple attachment sites that influence brain activity.

Featured Neurology Neuroscience

·January 3, 2025·5 min read

Ketamine Offers Hope for Parkinson’s Treatment-Linked Dyskinesia

Researchers have uncovered a new understanding of levodopa-induced dyskinesia, a common side effect in Parkinson’s patients, revealing that the motor cortex disconnects rather than directly causing these movements.

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ketamine

Buprenorphin and Ketamine Combo Provide Anti-Suicidal Effect

How Scientists Cracked the Ketamine Code for Depression

Blocking NOX-1 Extends Ketamine’s Effectiveness for Depression

Ketamine Restores Plasticity via AMPA Receptors

Ketamine Revolution: Study Redefines Depression Treatment

Ketamine Fails to Outperform Placebo in Major Depression Trial

Ketamine Plus Therapy Offers Lasting Relief for Severe Depression

Boosting Ketamine’s Antidepressant Effects to Last Two Months

Brain Wave Phase Locking May Be Key to Unconsciousness

Ketamine’s Hidden Physical and Psychological Damage

How Ketamine Binds to Brain Receptors to Alter Mood

Ketamine Offers Hope for Parkinson’s Treatment-Linked Dyskinesia

Caffeine Destroys Deep Sleep Waves Without Altering Duration

Simple Dietary Switches Lower Clinical Depression

Modified FDA Drug Blocks Pediatric Brain Tumor Relapse

Blood Proteins Identified That Predict Multiple Sclerosis Early

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