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iron

·September 10, 2025·4 min read

Brain Iron Levels Predict Cognitive Decline Risk

A new study demonstrates that brain iron levels, measured with a special MRI technique, can predict cognitive decline years before symptoms of Alzheimer’s disease appear. Researchers followed 158 cognitively healthy older adults and found that higher iron levels in memory-related regions of the brain were associated with a greater risk of mild cognitive impairment.

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·April 29, 2025·5 min read

Boosting Iron May Ease Brain Fog

New research shows that women with healthy blood iron levels during menopause perform better on cognitive tasks like memory and attention. The study found that sufficient blood iron was linked to better brain function without increasing harmful iron deposits in the brain.

Featured Neurology Neuroscience

·September 5, 2023·5 min read

Iron Buildup Triggers Cell Death in Alzheimer’s

Researchers identified a new form of cell death, termed ferroptosis, in Alzheimer’s disease and vascular dementia. This process involves the destruction of microglia cells—brain immune cells—due to the accumulation of iron.

Featured Neurology Neuroscience

·December 6, 2022·3 min read

How Neurons Respond to Aged-Related Iron Accumulation

Researchers identified two genes that respond to age-related iron accumulation in the substantia nigra. Knockdown of these genes results in severely impairing the cellular tolerance for iron toxicity.

Featured Neurology Neuroscience

·August 1, 2022·5 min read

Iron Buildup in Brain Linked to Higher Risk for Movement Disorders

Those with hereditary hemochromatosis who have two copies of the gene mutation that cause the disorder have an increased risk of developing movement disorders including Parkinson's disease.

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·July 10, 2022·4 min read

Stress Affects Fetus’ Ability to Absorb Iron

Chronic stress experienced by a woman in the later stages of pregnancy can affect her fetus' ability to absorb iron by up to 15%. Researchers say the effects of iron deficiency are more noticeable in male fetuses.

This shows hepcidin expression in the brain

Featured Neurology Neuroscience Open Neuroscience Articles

·February 1, 2022·4 min read

Iron Accumulation Linked With Age-Related Cognitive Decline

A breakdown in regulatory mechanisms causes iron to build up in the brain during aging, increasing oxidative stress and increasing the risk of age-related cognitive decline, a new study reports.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·December 16, 2021·4 min read

Parkinson’s Disease Mutation Misdirects Iron in the Brain

Findings reveal a common Parkinson's disease genetic mutation drives mislocalization of iron in activated microglia.

Featured Neurology Neuroscience

·August 20, 2021·3 min read

Physical Exercise Modulates Iron in Alzheimer’s Disease

Regular exercise modulates iron storage and trafficking in the brain and skeletal muscles, and physical activity reduces cortical hepcidin. The findings reveal how exercise can be beneficial for those with Alzheimer's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·June 9, 2021·1 min read

Elemental Copper and Iron Found Within the Brains of Deceased Alzheimer’s Patients

Researchers found tiny deposits of elemental copper and iron in the brains of Alzheimer's patients. The findings may shed new light on how these elemental metals contribute to Alzheimer's development and progression.

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·September 9, 2020·4 min read

Vitamin B1 Deficiency a Key Factor in the Development of Alcohol-Related Dementia

Researchers hypothesize vitamin B1 (thiamine) deficiency may play a significant role in dementia associated with alcohol use disorder. It is known iron deposits in the brain contribute to neurodegenerative diseases. Those with AUD have elevated levels of both iron in their blood and thiamine deficiency. Thiamine is vital for maintaining the blood-brain barrier. Thiamine deficiency associated with AUD disrupts the integrity of the BBB, allowing for more iron deposits within the brain and leading to oxidative tissue damage.