A new 3D human gut organoid reveals the molecular system that keeps the intestinal linings sealed and how dysfunction can occur. Findings reveal the diabetes drug metformin can help strengthen the intestinal lining. Read More
Two studies reveal the role bile acids play in immunity and inflammation. Read More
Short term increases in sugar consumption raise the susceptibility to colitis and worsen symptoms of inflammatory bowel disease in mouse models. Read More
Study provides new insights into how the immune system and inflammation play a role in the development and progression of Parkinson's disease. Read More
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems. Read More
Children with inflammatory bowel disease (IBD) are at increased risk of being diagnosed with a mental health problem. The risk of being diagnosed with a psychiatric condition is 1.6 times higher for those with IBD than the general population. IBD is associated with an increased risk of eating disorders, anxiety, depression, personality disorders, and ASD diagnosis. Researchers report there is also an increased risk of suicidal thoughts when the child reaches adulthood. The risk of being diagnosed with a psychiatric disorder was highest during the first year of IBD diagnosis, especially in children diagnosed with the condition before the age of 6. Read More
A link between disease activity in those with inflammatory bowel disease and less positive biases in emotional regulation could explain a higher risk of depression in those with IBD. Read More
Children who spend time playing outside in the sunshine have a 20% decreased risk of developing inflammatory bowel disease. Read More
Diagnosis of inflammatory bowel diseases like Crohn's disease and ulcerative colitis during adulthood has been linked to a 50% higher mortality rate and shorter life expectancy in those over 50. The increased risk of death remained after the introduction of therapies aimed at treating the conditions but decreased over time. Read More
Study reports type 2 diabetes and other obesity related health disorders depend on how the body stores excess fat. Researchers report visceral adipose tissue may be a cause of pathogenic obesity. Read More
Researchers report an elevated risk of women with inflammatory bowel disease being diagnosed with mental health problems after giving birth. The study reports that for every 43 pregnancies, there is one case of a new mental illness diagnosis for women with IBD compared to women without the condition. Read More
Researchers reveal patients with inflammatory bowel disease are 28% more likely to develop Parkinson's disease. However, an anti-inflammatory treatment used to help those with IBD can significantly decrease the risk of developing the neurodegenerative disease. Read More
