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huntingtin

Featured Genetics Neurology Open Neuroscience Articles

·September 14, 2016·4 min read

Protecting Nerve Cells From Huntington’s Disease

Researchers have discovered a way in which it could be possible to stop proteins from triggering energy failure inside nerve cells in those affected by Huntington's disease.

Image shows a brain slice from a huntington's patient.

Featured Genetics Neurology Open Neuroscience Articles

·September 9, 2016·5 min read

Activity of Huntington’s Disease Gene Curbed for 6 Months: Mouse Study

Researchers have identified a protein that can turn off the Huntingtin gene's expression.

Image shows striatal neurons from a patient with huntington's disease.

Featured Genetics Neurology

·September 5, 2016·3 min read

Protein Subunit Found to Rescue Afflicted Neurons in Huntington’s Disease

Researchers use a novel co-culturing method to create functional circuits that model Huntington's disease and find new clues to potential treatment approaches.

This shows huntingtin protein aggregates.

Featured Neurology

·April 23, 2015·3 min read

Novel Regulator Inhibits Toxic Protein Aggregates in Huntington’s Disease

Researchers discover a novel factor which suppresses misfolding and aggregation of the huntingtin protein.

This image shows the crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallographic purposes.

Featured Neurology

·October 28, 2014·3 min read

Scientists Uncover Major Factor in Development of Huntingtons Disease

A new study points to a functional connection between mTOR and huntingtin.

The image shows ApHTT mRNA expression in Aplysia sensory neurons.

Featured Genetics Open Neuroscience Articles

·August 12, 2014·2 min read

A Gene Linked to Disease Found to Play a Critical Role in Normal Memory Development

Researchers report huntingtin plays a critical role in long-term memory.

These slides show the comparison morphographies associated with the research.

Featured Genetics Open Neuroscience Articles

·December 11, 2013·3 min read

Staying Ahead of Huntington’s Disease

Researchers work to understand how expanded polyglutamine tracts form the types of supramolecular structures that are presumed to be toxic to neurons.

This is a montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin.

Featured Neurology Open Neuroscience Articles

·July 29, 2013·3 min read

Essential Clue to Huntington’s Disease Solution Found

Researchers have developed a new way in which to measure the shape of the huntingtin protein in living cells.

This is an image of a striatal neuron with activated Dendra2 protein.

Featured Neurology

·July 21, 2013·5 min read

For a Healthy Brain, Don’t Let the Trash Pile Up

A new study indicates that quickly clearing away defective proteins in the brain could help prevent some neurodegenerative disorders.

The image shows defective protein cells. The caption best describes the image.

Featured Genetics

·February 26, 2013·5 min read

Researchers Find Controlling Element of Huntington’s Disease

Researchers discover a three molecule complex could be a target for treating Huntington's Disease, a genetic and currently incurable brain disease which causes movement disorders and dementia.

Featured Neurology

·September 17, 2012·3 min read

Toxic Protein Build-up in Blood Shines Light on Fatal Brain Disease

A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.

Featured Genetics Neurology

·July 11, 2012·3 min read

Two Proteins Offer a Clearer Way to Treat Huntington’s Disease

HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.

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huntingtin

Protecting Nerve Cells From Huntington’s Disease

Activity of Huntington’s Disease Gene Curbed for 6 Months: Mouse Study

Protein Subunit Found to Rescue Afflicted Neurons in Huntington’s Disease

Novel Regulator Inhibits Toxic Protein Aggregates in Huntington’s Disease

Scientists Uncover Major Factor in Development of Huntingtons Disease

A Gene Linked to Disease Found to Play a Critical Role in Normal Memory Development

Staying Ahead of Huntington’s Disease

Essential Clue to Huntington’s Disease Solution Found

For a Healthy Brain, Don’t Let the Trash Pile Up

Researchers Find Controlling Element of Huntington’s Disease

Toxic Protein Build-up in Blood Shines Light on Fatal Brain Disease

Two Proteins Offer a Clearer Way to Treat Huntington’s Disease

Memory Rewritten: Study Finds No Clear Line Between Episodic and Semantic Retrieval

Brain Stimulation Method Can Evaluate Consciousness in Alzheimer’s Disease

Early Intervention Helps Most Autistic Children Acquire Spoken Language

Brain Conductors Find Precise Connection to Target Cells via Protein Handshake

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