A new study reveals that a natural cannabinoid in the body, 2-AG, plays a crucial role in regulating fear responses, particularly in individuals with PTSD and anxiety. Researchers found that lower levels of 2-AG in both mice and humans were linked to exaggerated or overgeneralized fear reactions to non-threatening stimuli. This suggests that 2-AG helps the brain distinguish real threats from harmless cues, acting as a natural filter for fear.