Mice lacking a specific serotonin receptor unlearn fear faster than those with the receptor. The findings open the door to the development of new treatments for PTSD and other disorders associated with fear.
Behavioral inhibition at 12 to 24 months of age was associated with an increased risk of developing depression, more so than anxiety, during later life. This is especially true for inhibited children who showed blunted activity in the ventral striatum during adolescence.
Exposure therapy for fears and phobias may only have a 50% success rate because fear memories outlast competing safety memories learned from therapy. Researchers investigate the genesis of fear memories and have developed a new mathematical model to help strengthen exposure therapies.
The TOB gene plays a significant role in reducing depression, anxiety, and fear in mouse models. The findings could have positive implications for developing new treatments for disorders associated with psychiatric stress.
CGRP neurons found in subregions of the thalamus and brainstem relay multisensory threat information to the amygdala. These neural circuits are essential for the formation of aversive memories, a new study reports.